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Mitochondrial dysfunction is a key pathological driver of early stage Parkinson's.

Autor: Toomey, Christina E.^1,2,3 (AUTHOR) christina.toomey@ucl.ac.uk, Heywood, Wendy E.⁴ (AUTHOR), Evans, James R.^2,3 (AUTHOR), Lachica, Joanne^1,2 (AUTHOR), Pressey, Sarah N.¹ (AUTHOR), Foti, Sandrine C.^1,5 (AUTHOR), Al Shahrani, Mesfer^6,7 (AUTHOR), D'Sa, Karishma^2,3 (AUTHOR), Hargreaves, Iain P.⁶ (AUTHOR), Heales, Simon⁶ (AUTHOR), Orford, Michael⁶ (AUTHOR), Troakes, Claire⁸ (AUTHOR), Attems, Johannes⁹ (AUTHOR), Gelpi, Ellen^10,11 (AUTHOR), Palkovits, Miklos¹² (AUTHOR), Lashley, Tammaryn^1,5 (AUTHOR), Gentleman, Steve M.¹³ (AUTHOR), Revesz, Tamas^1,5 (AUTHOR), Mills, Kevin⁴ (AUTHOR), Gandhi, Sonia^2,3 (AUTHOR) sonia.gandhi@ucl.ac.uk

Publikováno v: Acta Neuropathologica Communications. 9/8/2022, Vol. 10 Issue 1, p1-25. 25p.

Artificial intelligence for dementia genetics and omics

Autor: Bettencourt, Conceicao, Skene, Nathan, Bandres-Ciga, Sara, Anderson, Emma, Winchester, Laura M, Foote, Isabelle F, Schwartzentruber, Jeremy, Botia, Juan A, Nalls, Mike, Singleton, Andrew, Schilder, Brian M, Humphrey, Jack, Marzi, Sarah J, Toomey, Christina E, Al Kleifat, Ahmad, Harshfield, Eric L, Garfield, Victoria, Sandor, Cynthia, Keat, Samuel, Tamburin, Stefano, Sala Frigerio, Carlo, Lourida, Ilianna, Ranson, Janice M, Llewellyn, David J

INTRODUCTION: Genetics and omics studies of Alzheimer’s disease and other dementia subtypes enhance our understanding of underlying mechanisms and pathways that can be targeted. METHODS: We identified key remaining challenges: First, can we enhance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db67979cf3030482e064189e75fda9e0

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Mitochondrial dysfunction is a key pathological driver of early stage Parkinson's

Autor: Toomey, Christina E, Heywood, Wendy E, Evans, James R, Lachica, Joanne, Pressey, Sarah N, Foti, Sandrine C, Al Shahrani, Mesfer, D'Sa, Karishma, Hargreaves, Iain P, Heales, Simon, Orford, Michael, Troakes, Claire, Attems, Johannes, Gelpi, Ellen, Palkovits, Miklos, Lashley, Tammaryn, Gentleman, Steve M, Revesz, Tamas, Mills, Kevin, Gandhi, Sonia

BACKGROUND: The molecular drivers of early sporadic Parkinson's disease (PD) remain unclear, and the presence of widespread end stage pathology in late disease masks the distinction between primary or causal disease-specific events and late secondary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a6d5ee9209f566edc7cd134a97977a