Predictive Factors for BRCA1 and BRCA2 Genetic Testing in an Asian Clinic-Based Population.

Autor: Edward S Y Wong, Sandhya Shekar, Claire H T Chan, Lewis Z Hong, Suk-Yean Poon, Toomas Silla, Clarabelle Lin, Vikrant Kumar, Sonia Davila, Mathijs Voorhoeve, Aye Aye Thike, Gay Hui Ho, Yoon Sim Yap, Puay Hoon Tan, Min-Han Tan, Peter Ang, Ann S G Lee

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0134408 (2015)

The National Comprehensive Cancer Network (NCCN) has proposed guidelines for the genetic testing of the BRCA1 and BRCA2 genes, based on studies in western populations. This current study assessed potential predictive factors for BRCA mutation probabi

Externí odkaz: https://doaj.org/article/17fe3ee275054f9785a5cbd94d4b7ec0

The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay

Autor: Yuhui Dou, William A. Garland, Miha Milek, Torben Heick Jensen, Toomas Silla, Manfred Schmid, Patrik Polak, Matthias Selbach, Koshi Imami, Markus Landthaler, Dennis Johnsen, Jens S. Andersen

Publikováno v: Nucleic Acids Research
Silla, T, Schmid, M, Dou, Y, Garland, W, Milek, M, Imami, K, Johnsen, D, Polák, P, Andersen, J S, Selbach, M, Landthaler, M & Jensen, T H 2020, ' The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay ', Nucleic Acids Research, vol. 48, no. 5, pp. 2518-2530 . https://doi.org/10.1093/nar/gkz1238
Silla, T, Schmid, M, Dou, Y, Garland, W, Milek, M, Imami, K, Johnsen, D, Polak, P, Andersen, J S, Selbach, M, Landthaler, M & Jensen, T H 2020, ' The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay ', Nucleic acids research, vol. 48, no. 5, pp. 2518-2530 . https://doi.org/10.1093/nar/gkz1238

Recruitment of the human ribonucleolytic RNA exosome to nuclear polyadenylated (pA+) RNA is facilitated by the Poly(A) Tail eXosome Targeting (PAXT) connection. Besides its core dimer, formed by the exosome co-factor MTR4 and the ZFC3H1 protein, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c47df265116e9f2f181075ba7d672417
https://pubmed.ncbi.nlm.nih.gov/31950173

The lncRNA NEAT1_1 is dispensable for normal tissue homeostasis and cancer cell growth

Autor: Tetsuro Hirose, Toomas Silla, Torben Heick Jensen, Tomoki Chiba, Florian Rambow, Hiroshi A, Mari Mito, Greet Bervoets, Carmen Adriaens, Jean-Christophe Marine, Shinichi Nakagawa

NEAT1 is one of the most studied lncRNAs, in part because its silencing in mice causes defects in mammary gland development and corpus luteum formation, and protects them from skin cancer development. Moreover, depleting NEAT1 in established cancer c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dfea3bdb73e8f37471386364dfccb8d

Brd4 Is Involved in Multiple Processes of the Bovine Papillomavirus Type 1 Life Cycle

Autor: Kristina Mäemets, Mart Ustav, Ivar Ilves, Kadri Janikson, Toomas Silla

Publikováno v: Journal of Virology. 80:3660-3665

Brd4 protein has been proposed to act as a cellular receptor for the bovine papillomavirus type 1 (BPV1) E2 protein in the E2-mediated chromosome attachment and mitotic segregation of viral genomes. Here, we provide data that show the involvement of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a1738fee47493d5a2f7f8260a7994d
https://doi.org/10.1128/jvi.80.7.3660-3665.2006

Episomal maintenance of plasmids with hybrid origins in mouse cells

Autor: Toomas Silla, Aare Abroi, Jelizaveta Geimanen, Ingrid Hääl, Kadri Janikson, Ene Ustav, Mart Ustav

Publikováno v: Journal of virology. 79(24)

Bovine papillomavirus type 1 (BPV1), Epstein-Barr virus (EBV), and human herpesvirus 8 genomes are stably maintained as episomes in dividing host cells during latent infection. The mitotic segregation/partitioning function of these episomes is depend

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bfce01ab572bddc6bd657377710cf72
https://pubmed.ncbi.nlm.nih.gov/16306599