Fused radical SAM and αKG-HExxH domain proteins contain a distinct structural fold and catalyse cyclophane formation and β-hydroxylation.

Autor: Morishita Y; Department of Pharmacy, National University of Singapore, Singapore, Singapore.; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan., Ma S; Department of Chemistry, Fudan University, Shanghai, China., De La Mora E; University Grenoble Alpes, CEA, CNRS, IBS, Metalloproteins Unit, Grenoble, France., Li H; Department of Chemistry, Fudan University, Shanghai, China., Chen H; Department of Chemistry, Fudan University, Shanghai, China., Ji X; Department of Chemistry, Fudan University, Shanghai, China., Usclat A; University Grenoble Alpes, CEA, CNRS, IBS, Metalloproteins Unit, Grenoble, France., Amara P; University Grenoble Alpes, CEA, CNRS, IBS, Metalloproteins Unit, Grenoble, France., Sugiyama R; Department of Pharmacy, National University of Singapore, Singapore, Singapore.; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan., Tooh YW; Department of Pharmacy, National University of Singapore, Singapore, Singapore., Gunawan G; Department of Pharmacy, National University of Singapore, Singapore, Singapore., Pérard J; University Grenoble Alpes, CNRS, CEA, IRIG, Laboratoire de Chimie et Biologie des Métaux, Grenoble, France., Nicolet Y; University Grenoble Alpes, CEA, CNRS, IBS, Metalloproteins Unit, Grenoble, France. yvain.nicolet@ibs.fr., Zhang Q; Department of Chemistry, Fudan University, Shanghai, China. qizhang@sioc.ac.cn., Morinaka BI; Department of Pharmacy, National University of Singapore, Singapore, Singapore. phambi@nus.edu.sg.

Publikováno v: Nature chemistry [Nat Chem] 2024 Nov; Vol. 16 (11), pp. 1882-1893. Date of Electronic Publication: 2024 Sep 18.

The Biosynthetic Landscape of Triceptides Reveals Radical SAM Enzymes That Catalyze Cyclophane Formation on Tyr- and His-Containing Motifs.

Autor: Sugiyama R; Department of Pharmacy, National University of Singapore, Singapore 117544, Singapore., Suarez AFL; Department of Pharmacy, National University of Singapore, Singapore 117544, Singapore., Morishita Y; Department of Pharmacy, National University of Singapore, Singapore 117544, Singapore., Nguyen TQN; Department of Pharmacy, National University of Singapore, Singapore 117544, Singapore., Tooh YW; Department of Pharmacy, National University of Singapore, Singapore 117544, Singapore., Roslan MNHB; Department of Pharmacy, National University of Singapore, Singapore 117544, Singapore., Lo Choy J; Department of Pharmacology and Toxicology, University of Toronto, Toronto M5S 1A8, Canada., Su Q; Department of Pharmacy, National University of Singapore, Singapore 117544, Singapore., Goh WY; Department of Pharmacy, National University of Singapore, Singapore 117544, Singapore., Gunawan GA; Department of Pharmacy, National University of Singapore, Singapore 117544, Singapore.; Molecular Engineering Lab, Institute of Molecular and Cell Biology, A*STAR, Singapore 138673, Singapore.; Organic & Biomolecular Chemistry, Institute of Sustainability for Chemicals, Energy and Environment, A*STAR, Singapore 138665, Singapore., Wong FT; Molecular Engineering Lab, Institute of Molecular and Cell Biology, A*STAR, Singapore 138673, Singapore.; Singapore Institute of Food and Biotechnology Innovation, A*STAR, Singapore 138673, Singapore., Morinaka BI; Department of Pharmacy, National University of Singapore, Singapore 117544, Singapore.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2022 Jul 06; Vol. 144 (26), pp. 11580-11593. Date of Electronic Publication: 2022 Jun 21.