Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Tooba, Murshedkar"'
Autor:
Anneth Tumbo, Freia-Raphaella Lorenz, Annie S.P. Yang, Stephanie Sefried, Tobias Schindler, Maximilian Mpina, Jean-Pierre Dangy, Florence A. Milando, Mohammed A. Rashid, Gloria Nyaulingo, Kamaka Ramadhani, Said Jongo, Philip L. Felgner, Yonas Abebe, B. Kim Lee Sim, L.W. Preston Church, Thomas L. Richie, Peter F. Billingsley, Tooba Murshedkar, Stephen L. Hoffman, Salim Abdulla, Peter G. Kremsner, Benjamin Mordmüller, Claudia Daubenberger, Rolf Fendel
Publikováno v:
EBioMedicine, Vol 108, Iss , Pp 105364- (2024)
Summary: Background: PfSPZ Vaccine, a promising pre-erythrocytic stage malaria vaccine candidate based on whole, radiation-attenuated Plasmodium falciparum (Pf) sporozoites (SPZ), has proven safe and effective in mediating sterile protection from mal
Externí odkaz:
https://doaj.org/article/608a577a935848f082781131f68893d7
Autor:
Thomas L. Richie, L.W. Preston Church, Tooba Murshedkar, Peter F. Billingsley, Eric R. James, Mei-Chun Chen, Yonas Abebe, Natasha KC, Sumana Chakravarty, David Dolberg, Sara A. Healy, Halimatou Diawara, Mahamadou S. Sissoko, Issaka Sagara, David M. Cook, Judith E. Epstein, Benjamin Mordmüller, Melissa Kapulu, Andrea Kreidenweiss, Blandine Franke-Fayard, Selidji T. Agnandji, María-Silvia A. López Mikue, Matthew B.B. McCall, Laura Steinhardt, Martina Oneko, Ally Olotu, Ashley M. Vaughan, James G. Kublin, Sean C. Murphy, Said Jongo, Marcel Tanner, Sodiomon B. Sirima, Matthew B. Laurens, Claudia Daubenberger, Joana C. Silva, Kirsten E. Lyke, Chris J. Janse, Meta Roestenberg, Robert W. Sauerwein, Salim Abdulla, Alassane Dicko, Stefan H. I. Kappe, B. Kim Lee Sim, Patrick E. Duffy, Peter G. Kremsner, Stephen L. Hoffman
Publikováno v:
Expert Review of Vaccines, Vol 0, Iss 0 (2023)
Introduction Malaria, a devastating febrile illness caused by protozoan parasites, sickened 247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in sub-Saharan Africa. A highly effective vaccine is urgently needed, especi
Externí odkaz:
https://doaj.org/article/64ccc130995e4fbda0570808ef7ca47d
Autor:
Benjamin Mordmüller, Zita Sulyok, Mihály Sulyok, Zsofia Molnar, Albert Lalremruata, Carlos Lamsfus Calle, Patricia Granados Bayon, Meral Esen, Markus Gmeiner, Jana Held, Henri-Lynn Heimann, Tamirat Gebru Woldearegai, Javier Ibáñez, Judith Flügge, Rolf Fendel, Andrea Kreidenweiss, Natasha KC, Tooba Murshedkar, Sumana Chakravarty, Pouria Riyahi, Peter F. Billingsley, L. W. Preston Church, Thomas L. Richie, B. Kim Lee Sim, Stephen L. Hoffman, Peter G. Kremsner
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-9 (2022)
Abstract Immunization with radiation-attenuated Plasmodium falciparum (Pf) sporozoites (SPZ) in PfSPZ Vaccine, has provided better vaccine efficacy (VE) against controlled human malaria infection (CHMI) with the same parasites as in the vaccine (homo
Externí odkaz:
https://doaj.org/article/14917a5ef92d4531811eec64c343ca82
Autor:
Joana C. Silva, Ankit Dwivedi, Kara A. Moser, Mahamadou S. Sissoko, Judith E. Epstein, Sara A. Healy, Kirsten E. Lyke, Benjamin Mordmüller, Peter G. Kremsner, Patrick E. Duffy, Tooba Murshedkar, B. Kim Lee Sim, Thomas L. Richie, Stephen L. Hoffman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Here the authors show that controlled human malaria infection with a Brazilian parasite highly divergent from vaccine and West African field strains can provide estimates of vaccine efficacy in Mali, and could replace field testing, streamlining vacc
Externí odkaz:
https://doaj.org/article/8adef3faef374367ad0d7275f5f65245
Autor:
Natasha KC, L. W. Preston Church, Pouria Riyahi, Sumana Chakravarty, Robert A. Seder, Judith E. Epstein, Kirsten E. Lyke, Benjamin Mordmüller, Peter G. Kremsner, Mahamadou S. Sissoko, Sara Healy, Patrick E. Duffy, Said A. Jongo, Vicente Urbano Nsue Ndong Nchama, Salim Abdulla, Maxmillian Mpina, Sodiomon B. Sirima, Matthew B. Laurens, Laura C. Steinhardt, Martina Oneko, MingLin Li, Tooba Murshedkar, Peter F. Billingsley, B. Kim Lee Sim, Thomas L. Richie, Stephen L. Hoffman
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundWhile prior research has shown differences in the risk of malaria infection and sickness between males and females, little is known about sex differences in vaccine-induced immunity to malaria. Identifying such differences could elucidate i
Externí odkaz:
https://doaj.org/article/d6334f1741f1482b91e5bb9239e66e76
Autor:
Eric R. James, Steve Matheny, James Overby, B. Kim Lee Sim, Abraham G. Eappen, Tao Li, Ming Lin Li, Thomas L. Richie, Sumana Chakravarty, Anusha Gunasekera, Tooba Murshedkar, Peter F. Billingsley, Stephen L. Hoffman
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Ionizing radiation (UV, X-ray and ɣ) administered at an appropriate dose to pathogenic organisms can prevent replication while preserving metabolic activity. We have established the GMP process for attenuation by ionizing radiation of the Plasmodium
Externí odkaz:
https://doaj.org/article/f080f2a50f604070b6453d8d6f1822f5
Autor:
Said A. Jongo, Vicente Urbano Nsue Ndong Nchama, L. W. Preston Church, Ally Olotu, Stephen R. Manock, Tobias Schindler, Ali Mtoro, Natasha KC, Orrin Devinsky, Elcin Zan, Ali Hamad, Elizabeth Nyakarungu, Maxmillian Mpina, Anna Deal, José Raso Bijeri, Martin Eka Ondo Mangue, Beltrán Ekua Ntutumu Pasialo, Genaro Nsue Nguema, Matilde Riloha Rivas, Mwajuma Chemba, Kamaka K. Ramadhani, Eric R. James, Thomas C. Stabler, Yonas Abebe, Pouria Riyahi, Elizabeth S. Saverino, Julian Sax, Salome Hosch, Anneth Tumbo, Linda Gondwe, J. Luis Segura, Carlos Cortes Falla, Wonder Philip Phiri, Dianna E. B. Hergott, Guillermo A. García, Carl Maas, Tooba Murshedkar, Peter F. Billingsley, Marcel Tanner, Mitoha Ondo’o Ayekaba, B. Kim Lee Sim, Claudia Daubenberger, Thomas L. Richie, Salim Abdulla, Stephen L. Hoffman
Publikováno v:
The American Journal of Tropical Medicine and Hygiene.
The radiation-attenuated Plasmodium falciparum sporozoites (PfSPZ) Vaccine has demonstrated safety and immunogenicity in 5-month-old to 50-year-old Africans in multiple trials. Except for one, each trial has restricted enrollment to either infants an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92f079c3948abc5407bfcf8ad0e1767a
https://doi.org/10.4269/ajtmh.22-0773
https://doi.org/10.4269/ajtmh.22-0773
Autor:
Jacquelyn Lane, Thomas L. Richie, Bourama Kamate, Tooba Murshedkar, Patrick E. Duffy, Fanta Koita, Natasha Kc, Abdoulaye Katile, Ismaila Thera, Agnes Mwakingwe-Omari, Peter F. Billingsley, Stephen L. Hoffman, Anita Manoj, Cheick Oumar Guindo, Amagana Dolo, Merepen A Guindo, Eric R. James, Yacouba Samake, Kelly M. Rausch, Rathy Mohan, Karamoko Niare, B. Kim Lee Sim, Yonas Abebe, Kourane Sissoko, Alemush Imeru, Sara A. Healy, Zonghui Hu, Amadou Niangaly, Ogobara K. Doumbo, Aissatou Bah, Amatigue Zeguime, Mahamadou S Sissoko, Irfan Zaidi
Publikováno v:
Lancet Infect Dis
Summary Background WHO recently approved a partially effective vaccine that reduces clinical malaria in children, but increased vaccine activity is required to pursue malaria elimination. A phase 1 clinical trial was done in Mali, west Africa, to ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83671c7f40083807ec470d4e4da417fc
https://doi.org/10.1016/s1473-3099(21)00332-7
https://doi.org/10.1016/s1473-3099(21)00332-7
Autor:
Sumana Chakravarty, Eric R. James, Stephen L. Hoffman, Lei K. Ding, Jillian Neal, Charles Wyatt, Sahand Kalhori, Anita Manoj, Alemush Imeru, Omely Marte-Salcedo, Sangeeta N. Bhatia, Hope Decederfelt, David M. Cook, Agnes Mwakingwe-Omari, Martha Nason, Jen C. C. Hume, Sara A. Healy, Aarti Kolluri, Natasha Kc, Ijeoma Ikpeama, B. Kim Lee Sim, Peter F. Billingsley, Sean C. Murphy, L. W. Preston Church, Jihyun E. Jeon, Sandra March, Grace K. Lee, Irfan Zaidi, Jacob Raiten, Junhui Duan, Anusha Gunasekera, Thomas L. Richie, Tooba Murshedkar, Jacquelyn Lane, Patrick E. Duffy, Charles Anderson
Publikováno v:
Nature. 595:289-294
The global decline in malaria has stalled1, emphasizing the need for vaccines that induce durable sterilizing immunity. Here we optimized regimens for chemoprophylaxis vaccination (CVac), for which aseptic, purified, cryopreserved, infectious Plasmod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5683981db2e900df72762416f20eb4b7
https://doi.org/10.1038/s41586-021-03684-z
https://doi.org/10.1038/s41586-021-03684-z
Autor:
Claudia Daubenberger, Dianna Hergott, Said Jongo, Thomas L. Richie, Peter F. Billingsley, Maximillian Mpina, Jose Raso Bijeri, Ally Olotu, Tooba Murshedkar, Elizabeth Saverino, Linda Gondwe, Salome Hosch, Marcel Tanner, Eric R. James, Ali Hamad, Elizabeth Nyakarungu, Carl Maas, Ali Mtoro, Julian Sax, J. Luis Segura, Stephen L. Hoffman, Beltrán Ekua Ntutumu Pasialo, Natasha Kc, Anneth-Mwasi Tumbo, Wonder P. Phiri, Stephen R. Manock, Christopher Schwabe, Martin Eka Ondo Mangue, Mitoha Ondo’o Ayekaba, Mwajuma Chemba, Anna Deal, Vicente Urbano, Kamaka R Kassim, Genaro Nsue Nguema, Salim Abdulla, Salomon Nguema Owono, Yonas Abebe, Thomas C. Stabler, Matilde Riloha Rivas, Carlos Cortes Falla, Guillermo A. García, B. Kim Lee Sim, L. W. Preston Church, Tobias Schindler
Publikováno v:
The American Journal of Tropical Medicine and Hygiene
Plasmodium falciparum sporozoite (PfSPZ) Vaccine (radiation-attenuated, aseptic, purified, cryopreserved PfSPZ) and PfSPZ-CVac (infectious, aseptic, purified, cryopreserved PfSPZ administered to subjects taking weekly chloroquine chemoprophylaxis) ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a73006e115da126ab12463cf6b06adb
https://doi.org/10.4269/ajtmh.20-0435
https://doi.org/10.4269/ajtmh.20-0435