Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Tonya, Richards"'
Autor:
Tonya Richards, Jane Sanders, Katarzyna Kabelis, Jane Wilmot, Tetsuya Tagami, Jill Clark, Bernard Rees Smith, Emma Roberts, Xiaoling Hu, Stuart Young, Jadwiga Furmaniak, Alastair Collyer, Paul W. Sanders, Michele Evans, Sabrina Holl
Publikováno v:
Clinical Endocrinology. 73:404-412
Summary Objective Patients who appear to have both stimulating and blocking TSHR autoantibodies in their sera have been described, but the two activities have not been separated and analysed. We now describe the isolation and detailed characterizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1eaa7dd319bb204f05290c06f6939e4
https://doi.org/10.1111/j.1365-2265.2010.03831.x
https://doi.org/10.1111/j.1365-2265.2010.03831.x
Autor:
Rebecca Harris, Jane Sanders, Emma Roberts, Corrado Betterle, Paul W. Sanders, Kasemsri Small, Jane Wilmot, Stuart Young, Renato Zanchetta, Shu Chen, Anshu Bhardwaja, Angela Kiddie, Michele Evans, Graziella Coco, Bernard Rees Smith, Jadwiga Furmaniak, Sara Summerhayes, Magnus Reeve, Tonya Richards, Hayley Platt
Publikováno v:
Thyroid. 18:735-746
Human monoclonal autoantibodies (MAbs) are valuable tools to study autoimmune responses. To date only one human MAb to the thyrotropin (TSH) receptor (TSHR) with stimulating activity has been available. We now describe the detailed characterization o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc62be3d0cb8b630f7d196dbf72191f
https://doi.org/10.1089/thy.2007.0327
https://doi.org/10.1089/thy.2007.0327
Autor:
Antonio Dimida, Aldo Pinchera, P Agretti, Tonya Richards, B. Rees Smith, Jadwiga Furmaniak, Massimo Tonacchera, Matthew J. Evans, E. Ferrarini, Jay H. Sanders, G. De Marco
Publikováno v:
Thyroid. 16:1085-1089
The glycoprotein hormones luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyrotropin (TSH) show low-level cross-reactivity between their respective receptors (R). Patient serum autoantibodies to the thyrotropin receptor (TSHR) do n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4e535be08ce4a6cf4e065c8b211149
https://doi.org/10.1089/thy.2006.16.1085
https://doi.org/10.1089/thy.2006.16.1085
Autor:
Jane Bolton, R Núñez Miguel, Dimitri Y. Chirgadze, B. Rees Smith, Julia Sanders, Matthew J. Evans, Jadwiga Furmaniak, Hilde Depraetere, Frank H. Allen, Tonya Richards, Angela Kiddie, Lakdasa Premawardhana, Jennifer Jeffreys, Tom L. Blundell, Nobuhiro Nakatake
Publikováno v:
Thyroid. 15:672-682
Analysis of nine mouse monoclonal antibodies (mAbs) to the thyrotropin receptor (TSHR) with TSH antagonist activity showed that only one of the mAbs (RSR B2) was an effective antagonist of the human thyroid stimulating autoantibody M22. Crystals of B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a627ccaa70855b848d30848500dfce8
https://doi.org/10.1089/thy.2005.15.672
https://doi.org/10.1089/thy.2005.15.672
Autor:
Tom L. Blundell, Dimitri Y. Chirgadze, Tonya Richards, R Núñez Miguel, Jadwiga Furmaniak, Jennifer Jeffreys, Lakdasa Premawardhana, B. Rees Smith, Matthew J. Evans, K Brereton, Hilde Depraetere, Julia Sanders, Angela Kiddie
Publikováno v:
Thyroid. 14:560-570
The properties of a human monoclonal antibody to the thyrotropin receptor (TSHR) (M22) with the characteristics of patient sera thyroid stimulating autoantibodies is described. Similar concentrations (pmol/L) of M22 Fab and porcine TSH had similar st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84f0ae82ac1700e9bdc91fdafbb3f99f
https://doi.org/10.1089/1050725041692918
https://doi.org/10.1089/1050725041692918
Autor:
Yasuo Oda, Jane Sanders, Bernard Rees Smith, Jennifer Jeffreys, Tonya Richards, Angela Kiddie, Jadwiga Furmaniak, Michele Evans, Hilde Depraetere
Publikováno v:
Thyroid. 12:1051-1061
A panel of monoclonal antibodies (mAbs) to the thyrotropin receptor (TSHR) was prepared using three different immunization strategies. The mAbs obtained (n = 138) reacted with linear epitopes covering most of the TSHR extracellular domain and with co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82b1cc693a69c4c2da1f4a392710f88
https://doi.org/10.1089/105072502321085144
https://doi.org/10.1089/105072502321085144
Autor:
Jennifer Jeffreys, B. Rees Smith, Jadwiga Furmaniak, Julia Sanders, Tonya Richards, Michele Evans, Hilde Depraetere, Lakdasa Premawardhana
Publikováno v:
The Lancet. 362:126-128
A monoclonal autoantibody (MAb) with powerful thyroid stimulating activity has been produced from lymphocytes from a patient with Graves' disease. The autoantibody and its Fab fragment bind to the thyroid stimulating hormone (TSH) receptor (TSHR) wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90416f7e213f917d5c8c618eac817a05
https://doi.org/10.1016/s0140-6736(03)13866-4
https://doi.org/10.1016/s0140-6736(03)13866-4
Autor:
Michele, Evans, Jane, Sanders, Tetsuya, Tagami, Paul, Sanders, Stuart, Young, Emma, Roberts, Jane, Wilmot, Xiaoling, Hu, Katarzyna, Kabelis, Jill, Clark, Sabrina, Holl, Tonya, Richards, Alastair, Collyer, Jadwiga, Furmaniak, Bernard Rees, Smith
Publikováno v:
Clinical endocrinology. 73(3)
Patients who appear to have both stimulating and blocking TSHR autoantibodies in their sera have been described, but the two activities have not been separated and analysed. We now describe the isolation and detailed characterization of a blocking ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::423f17be53e9e8ba0ad2b0ea68fed153
https://pubmed.ncbi.nlm.nih.gov/20550534
https://pubmed.ncbi.nlm.nih.gov/20550534
Autor:
Ricardo Núñez Miguel, Stuart Baker, Bernard Rees Smith, Dimitri Y. Chirgadze, Tonya Richards, Paul W. Sanders, Jadwiga Furmaniak, Jane Sanders, Jane Bolton, Michael Powell, Tom L. Blundell, Anshu Bhardwaja, Michele Evans, Magnus Reeve, Nobuhiro Nakatake, Andrew Sullivan
Publikováno v:
Thyroid : official journal of the American Thyroid Association. 17(5)
To analyze interactions between the thyroid-stimulating hormone receptor (TSHR) and a thyroid-stimulating human monoclonal autoantibody (M22) at the molecular level.A complex of part of the TSHR extracellular domain (amino acids 1-260; TSHR260) bound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a365a4a9f172333b9aeb49a34c8d6823
https://pubmed.ncbi.nlm.nih.gov/17542669
https://pubmed.ncbi.nlm.nih.gov/17542669
Autor:
Sara Summerhayes, Bernard Rees Smith, Jane Sanders, Jane Bolton, Tonya Richards, Jadwiga Furmaniak, Angela Kiddie, Michele Evans, Nobuhiro Nakatake, Paul W. Sanders, Emma Roberts, Ricardo Núñez Miguel, Jennifer Jeffreys
Publikováno v:
Thyroid : official journal of the American Thyroid Association. 16(12)
The effects of an extensive series of mutations in the TSH receptor (TSHR) leucine-rich domain (LRD) on the ability of thyroid-stimulating monoclonal antibodies (TSMAbs) and TSH to bind to the receptor and stimulate cyclic AMP production in TSHR-tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62f1ae05242f0b66d186ee8d220ae7b
https://pubmed.ncbi.nlm.nih.gov/17199429
https://pubmed.ncbi.nlm.nih.gov/17199429