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Computational modeling studies reveal the origin of the binding preference of 3-(3,4-di hydroisoquinolin-2(1H)-ylsulfonyl)benzoic acids for AKR1C3 over its isoforms

Autor: Xiaotian Kong, Enming Xing, Sijin Wu, Tony Zhuang, Pui‐Kai Li, Chunhua Li, Xiaolin Cheng

Publikováno v: Protein science : a publication of the Protein Society. 31(12)

As a key regulator for hormone activity, human aldo-keto reductase family 1 member C3 (AKR1C3) plays crucial roles in the occurrence of various hormone-dependent or independent malignancies. It is a promising target for treating castration-resistant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::533b18ba918b6783c0060d1334820fac
https://pubmed.ncbi.nlm.nih.gov/36335585

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Association of baseline inflammatory biomarkers with outcomes in penile squamous cell carcinoma (pSCC) treated with immune checkpoint inhibitors (ICI)

Autor: Tony Zhuang, Subir Goyal, Jacqueline T Brown, Bradley Curtis Carthon, Omer Kucuk, Greta Russler McClintock, Lauren Beth Yantorni, Mehmet Asim Bilen, Viraj A. Master, Bassel Nazha

Publikováno v: Journal of Clinical Oncology. 41:11-11

11 Background: Penile squamous cell carcinoma (pSCC) is a rare neoplasm with a poor prognosis and a need for biomarkers to guide treatment selection. We report an association of baseline inflammatory markers with outcomes in pSCC treated with immune

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0d8b8cdcd98d507894697370af99f0b
https://doi.org/10.1200/jco.2023.41.6_suppl.11

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SOHO State of the Art Updates and Next Questions: Managing Relapsed Mantle Cell Lymphoma

Autor: Jason T. Romancik, Drew G. Gerber, Tony Zhuang, Jonathon B. Cohen

Publikováno v: Clinical lymphoma, myelomaleukemia. 22(8)

Mantle cell lymphoma (MCL) is a rare subtype of B-cell non-Hodgkin lymphoma i.e., incurable with current therapies. While some patients experience prolonged remissions following initial therapy, most will have a relapsing-remitting course requiring s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a75697c6654157c23fb42dc0d9164c
https://pubmed.ncbi.nlm.nih.gov/35123927

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Mechanistic Insights into the Allosteric Inhibition of Androgen Receptors by Binding Function 3 Antagonists from an Integrated Molecular Modeling Study

Autor: Enming Xing, Tony Zhuang, Pui-Kai Li, Xiaolin Cheng, Xiaotian Kong

Publikováno v: Journal of chemical information and modeling. 61(7)

An androgen receptor (AR) is an intensively studied treatment target for castration-resistant prostate cancer that is irresponsive to conventional antiandrogen therapeutics. Binding function 3 (BF3) inhibitors with alternative modes of action have em

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf2ca50b466d893c59327d2be5f60a5
https://pubmed.ncbi.nlm.nih.gov/34165949

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Branched-Chain Fatty Acid Content Modulates Structure, Fluidity, and Phase in Model Microbial Cell Membranes

Autor: Tony Zhuang, Xiaolin Cheng, Barmak Mostofian, Jonathan D. Nickels

Publikováno v: The Journal of Physical Chemistry B. 123:5814-5821

Recent progress in understanding the importance and origins of lipid rafts in microbial cell membranes has focused attention on membranes containing branched-chain fatty acids. The working hypothesis is that branched fatty acids increase the fluidity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed1cfdb21dfadf24731ead5ba9fda69
https://doi.org/10.1021/acs.jpcb.9b04326

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A Cellular Automata Model for Dynamics and Control of Cardiac Arrhythmias

Autor: Kai Sun, Tony Zhuang, Xiaopeng Zhao, Min Xiong, Danny Gallenberger, Elena G. Tolkacheva

Publikováno v: Volume 1: Adaptive/Intelligent Sys. Control; Driver Assistance/Autonomous Tech.; Control Design Methods; Nonlinear Control; Robotics; Assistive/Rehabilitation Devices; Biomedical/Neural Systems; Building Energy Systems; Connected Vehicle Systems; Control/Estimation of Energy Systems; Control Apps.; Smart Buildings/Microgrids; Education; Human-Robot Systems; Soft Mechatronics/Robotic Components/Systems; Energy/Power Systems; Energy Storage; Estimation/Identification; Vehicle Efficiency/Emissions.

As a leading cause of death in 325,000 adults per year in the United States, a significant proportion of sudden cardiac arrest (SCA) result from arrhythmias. To better understand the onset of arrhythmias and its potential treatment with more rapid an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c64e26819c27b45a150efb8d3927500
https://doi.org/10.1115/dscc2020-3129

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