Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Tony Y. Wang"'
Autor:
Tony Y. Wang, Dan E. Arking, Joseph J. Maleszewski, Karen Fox-Talbot, Tim O. Nieuwenhuis, Lakshmi Santhanam, Renu Virmani, Avi Z. Rosenberg, Marc K. Halushka
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
Abstract Sex disparities modulate cardiac function, although the proteins and mechanisms remain to be elucidated. We recently demonstrated a mosaic pattern of protein expression in the heart for over 100 proteins. Here we investigate one of these pro
Externí odkaz:
https://doaj.org/article/c652c0835d9b4550b6cb7d45311e73b4
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 9, Pp 1691-1700 (2015)
To distinguish the lithogenic effect of the classical estrogen receptor α (ERα) from that of the G protein-coupled receptor 30 (GPR30), a new estrogen receptor, on estrogen-induced gallstones, we investigated the entire spectrum of cholesterol crys
Externí odkaz:
https://doaj.org/article/df41a5779f9a41b5b865a7fe808a03d5
Autor:
Ornella de Bari, Tony Y. Wang, Min Liu, Chang-Nyol Paik, Piero. Portincasa, David Q.-H. Wang, M.D., Ph.D.
Publikováno v:
Annals of Hepatology, Vol 13, Iss 6, Pp 728-745 (2014)
Epidemiological and clinical studies have found that gallstone prevalence is twice as high in women as in men at all ages in every population studied. Hormonal changes occurring during pregnancy put women at higher risk. The incidence rates of biliar
Externí odkaz:
https://doaj.org/article/14439e92ed934acd909fc4bc5091971e
Autor:
Tony Y. Wang, Chiara Piubelli, Lee T. Schaller, Pierette Banker, Stefano Tacconi, Paula Selley, Todd W. Shearer, Robert A. Reid, Federico Faggioni, Daniel J. Price, Richard F. Cox, Shawn P. Williams, David H. Drewry, Michela Tessari, Richard G. Buckholz, Patrick R. Maloney, Paul R. Reid, Brian D. Thompson, Xi Liang, Jeffery L. Smith, Octerloney B. McDonald, Ilaria Sartori
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:1958-1963
Hypothalamic CAMKK2 represents a potential mechanism for chemically affecting satiety and promoting weight loss in clinically obese patients. Single-digit nanomolar inhibitors of CAMKK2 were identified in three related ATP-competitive series. Limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ef3d3a14b6690b03d61d51517e7124
https://doi.org/10.1016/j.bmcl.2018.03.034
https://doi.org/10.1016/j.bmcl.2018.03.034
Autor:
Marc K. Halushka, Dongwong Lee, Aravinda Chakravarti, Tony Y. Wang, Karen Fox-Talbot, Dan E. Arking
Skeletal myocytes have well-established fast and slow twitch fibers with unique gene and protein specific expression patterns. By immunohistochemical staining, these show a mosaic pattern across myocytes. We hypothesized cardiac myocytes may behave s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dee8d54157c3b11d25cd7c9c4a02967
https://europepmc.org/articles/PMC5940500/
https://europepmc.org/articles/PMC5940500/
Publikováno v:
Current opinion in gastroenterology. 34(2)
The establishment of mouse models of gallstones, and the contribution of mouse models to genetic studies of gallstone disease, as well as the latest advances in the pathophysiology of gallstones from mouse experiments are summarized.The combined uses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1fca6e7dd715bc3098621b4dbfc386
https://pubmed.ncbi.nlm.nih.gov/29266008
https://pubmed.ncbi.nlm.nih.gov/29266008
Publikováno v:
Annals of Hepatology, Vol 13, Iss 6, Pp 728-745 (2014)
Epidemiological and clinical studies have found that gallstone prevalence is twice as high in women as in men at all ages in every population studied. Hormonal changes occurring during pregnancy put women at higher risk. The incidence rates of biliar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e0cf2acfc5a25e186192227f4563a0
https://doi.org/10.1016/s1665-2681(19)30975-5
https://doi.org/10.1016/s1665-2681(19)30975-5
Autor:
Yin Wang, Cameron Ackerley, Erica Tiberia, Alessandra Ruggieri, Peixiang Wang, Julie Turnbull, Tony Y. Wang, Johan Israelian, Berge A. Minassian, Xiao Chu Zhao, Nela Pencea, Yan Liu
Publikováno v:
Journal of Biological Chemistry. 287:25650-25659
The solubility of glycogen, essential to its metabolism, is a property of its shape, a sphere generated through extensive branching during synthesis. Lafora disease (LD) is a severe teenage-onset neurodegenerative epilepsy and results from multiorgan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9feaf2385a1498489abddf50efb8f5
https://doi.org/10.1074/jbc.m111.331611
https://doi.org/10.1074/jbc.m111.331611
Publikováno v:
Brain Research. 1107:82-96
Large-scale expansion of neural stem and progenitor cells will be essential for clinically treating the large number of patients suffering from neurodegenerative disorders such as Parkinson's disease. Other applications of neural stem cell technology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3378e5d8e0eee90fee22c0f5594ed1
https://doi.org/10.1016/j.brainres.2006.05.110
https://doi.org/10.1016/j.brainres.2006.05.110
Autor:
Jennifer Poole Peckham, Wendy Y. Mills, Terrence L. Smalley, Jayme Lyn Roark Wilson, Andrew J. Peat, Scott Howard Dickerson, Tony Y. Wang, Dulce Garrido, Stephanie L. Schweiker, Hui-Qiang Q. Zhou, Frank Preugschat, Joyce A. Boucheron, Stephen A. Thomson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:2121-2125
A series of [1-aryl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]arylhydrazones were discovered as novel inhibitors glycogen synthase kinase-3 (GSK-3). Based on initial modeling a detailed SAR was constructed. Modification of the interior binding aryl ring (Ar1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f47b3b411aa3acd6c34644b7c51ebc
https://doi.org/10.1016/j.bmcl.2004.02.036
https://doi.org/10.1016/j.bmcl.2004.02.036