Výsledky vyhledávání - "Tony Y. Shay"

Relating Collective Diffusion, Protein–Protein Interactions, and Viscosity of Highly Concentrated Monoclonal Antibodies through Dynamic Light Scattering

Autor: Tony Y. Shay, Carl A. Karouta, Ayush Sharma, Amjad Chowdhury, Jessica J. Hung, Keith P. Johnston, Maria P. Nieto, Kishan Ramachandran, Logan R. Wilks, Barton J. Dear, Thomas M. Truskett, Jason K. Cheung

Publikováno v: Industrial & Engineering Chemistry Research. 58:22456-22471

To understand and predict the viscosities of highly concentrated monoclonal antibody (mAb) solutions, it is important to characterize the protein–protein interactions (PPI) and how they influence t...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6e2a159f2a08f08392b26692f736a02
https://doi.org/10.1021/acs.iecr.9b03432

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Self-diffusion of a highly concentrated monoclonal antibody by fluorescence correlation spectroscopy: insight into protein–protein interactions and self-association

Autor: Jason K. Cheung, Tony Y. Shay, Thomas M. Truskett, Carl C. Hayden, Maria P. Nieto, Barton J. Dear, Carl A. Karouta, Wade F. Zeno, Keith P. Johnston, Amjad Chowdhury, Jeanne C. Stachowiak, Jessica J. Hung, Kishan Ramachandran

Publikováno v: Soft Matter. 15:6660-6676

The dynamic behavior of monoclonal antibodies (mAbs) at high concentration provides insight into protein microstructure and protein-protein interactions (PPI) that influence solution viscosity and protein stability. At high concentration, interpretat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66f4db2c89ca7b3bdce0c4f43f8e98e
https://doi.org/10.1039/c9sm01071h

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X-ray Scattering and Coarse-Grained Simulations for Clustering and Interactions of Monoclonal Antibodies at High Concentrations

Autor: P. Douglas Godfrin, Jessica J. Hung, Tony Y. Shay, Jason K. Cheung, Ayush Sharma, Keith P. Johnston, Maria P. Nieto, Amjad Chowdhury, Thomas M. Truskett, Dmytro Nykypanchuk, Jonathan A. Bollinger, Barton J. Dear, Carl A. Karouta, Kishan Ramachandran, Logan R. Wilks

Publikováno v: The journal of physical chemistry. B. 123(25)

Attractive protein?protein interactions (PPI) in concentrated monoclonal antibody (mAb) solutions may lead to reversible oligomers (clusters) that impact colloidal stability and viscosity. Herein, the PPI are tuned for two mAbs via the addition of ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb07e838aca0990d52e38a8794c881ed
https://pubmed.ncbi.nlm.nih.gov/31146525

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Protein-Protein Interactions of Highly Concentrated Monoclonal Antibody Solutions via Static Light Scattering and Influence on the Viscosity

Autor: Jonathan A. Bollinger, Jason K. Cheung, P. Douglas Godfrin, Amjad Chowdhury, Barton J. Dear, Thomas M. Truskett, Ayush Sharma, Jessica J. Hung, Kishan Ramachandran, Keith P. Johnston, Tony Y. Shay, Carl A. Karouta, Maria P. Nieto, Logan R. Wilks

Publikováno v: The journal of physical chemistry. B. 123(4)

The ability to design and formulate mAbs to minimize attractive interactions at high concentrations is important for protein processing, stability, and administration, particularly in subcutaneous delivery, where high viscosities are often challengin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ae31138bd751a62e26da14ac86505d
https://pubmed.ncbi.nlm.nih.gov/30614707

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