Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Tony W.H. Li"'
Autor:
Heping Yang, Jing Zhang, Jian Tu, Shelly C. Lu, Hui Peng, Tony W.H. Li, Wei Fan, Yuan Li, Jiaohong Wang, Ting Liu, José M. Mato, Yibu Chen, Justin Steggerda, Liqing Lu, Ting Xiong, Meng Li, Ekihiro Seki, Yongheng Chen, Zhigang Zhou
Publikováno v:
Hepatology
BACKGROUND AND AIMS Forkhead box M1 (FOXM1) and nuclear factor kappa B (NF-ĸB) are oncogenic drivers in liver cancer that positively regulate each other. We showed that methionine adenosyltransferase 1A (MAT1A) is a tumor suppressor in the liver and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09f93dd7d6fb437bdd6c425731cd8118
https://doi.org/10.1002/hep.31196
https://doi.org/10.1002/hep.31196
Autor:
Wei Fan, Ting Liu, Yuan Li, Ekihiro Seki, Liqing Lu, Shelly C. Lu, Michitaka Matsuda, Tony W.H. Li, Neil A. Bhowmick, Heping Yang, José M. Mato, Jing Zhang, Maria Lauda Tomasi, Lucía Barbier-Torres, Jiaohong Wang
Publikováno v:
Oncogene
Oncogene, vol 40, iss 39
Oncogene, vol 40, iss 39
Methionine adenosyltransferase 1A (MAT1A) is a tumor suppressor downregulated in hepatocellular carcinoma and cholangiocarcinoma, two of the fastest rising cancers worldwide. We compared MATα1 (protein encoded by MAT1A) interactome in normal versus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc1ae06f7a1279b7af61988fe756ad7
https://europepmc.org/articles/PMC9611740/
https://europepmc.org/articles/PMC9611740/
Autor:
Shelly C. Lu, Maria Lauda Tomasi, Ben Murray, Roberta A. Gottlieb, Lucía Barbier-Torres, Zhimin Lu, Wei Fan, Hui Peng, Jenny Van Eyk, Suthat Liangpunsakul, María L. Martínez-Chantar, José M. Mato, Nicholas J. Skill, Tony W.H. Li, Aaron E. Robinson
Publikováno v:
Hepatology (Baltimore, Md.), vol 70, iss 6
Hepatology
Hepatology
Methionine adenosyltransferase α1 (MATα1, encoded by MAT1A) is responsible for hepatic biosynthesis of S-adenosyl methionine, the principal methyl donor. MATα1 also act as a transcriptional cofactor by interacting and influencing the activity of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea7a9071fb8fbeea4c7480053bcb6b3
https://escholarship.org/uc/item/1m38q63w
https://escholarship.org/uc/item/1m38q63w
Autor:
Gregory J. Gores, Hui Peng, Heping Yang, Wei Fan, Ting Liu, Shelly C. Lu, Tony W.H. Li, Jiaohong Wang, Anuradha Krishnan, José M. Mato
Publikováno v:
Hepatology (Baltimore, Md.), vol 64, iss 2
Unlabelledc-Myc induction drives cholestatic liver injury and cholangiocarcinoma (CCA) in mice, and induction of Maf proteins (MafG and c-Maf) contributes to cholestatic liver injury, whereas S-adenosylmethionine (SAMe) administration is protective.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb7a885c8cd3934bacd9db5ef467a54
https://doi.org/10.1002/hep.28541
https://doi.org/10.1002/hep.28541
Autor:
Ting Liu, Stephanie S. Maldonado, Jiaohong Wang, Ekihiro Seki, Shelly C. Lu, José M. Mato, Hong Shen, Heping Yang, Jian Tu, Wei Fan, Mazen Noureddin, Jin Won Yang, Alagappan Annamalai, Ting Xiong, Tony W.H. Li, Justin Steggerda, Zhenqiu Liu
Publikováno v:
Gastroenterology, vol 155, iss 2
Background & Aims MAF bZIP transcription factor G (MAFG) is activated by the farnesoid X receptor to repress bile acid synthesis. However, expression of MAFG increases during cholestatic liver injury in mice and in cholangiocarcinomas. MAFG interacts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44410329c09fd1b986d380542b398679
https://escholarship.org/uc/item/1w822685
https://escholarship.org/uc/item/1w822685
Autor:
Ting Liu, Shelly C. Lu, Heping Yang, Yu Zhou, María L. Martínez-Chantar, Ebrahim Zandi, José M. Mato, Hui Peng, Tony W.H. Li
Publikováno v:
Antioxidants & Redox Signaling. 22:259-274
Aims: We showed that chronic cholestatic liver injury induced the expression of c-Myc but suppressed that of glutamate-cysteine ligase (GCL, composed of catalytic and modifier subunits GCLC and GCLM, respectively). This was associated with reduced nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267a03b8d271b6edbe741d99cbcaa44c
https://doi.org/10.1089/ars.2014.6027
https://doi.org/10.1089/ars.2014.6027
Autor:
Heping Yang, José M. Mato, Ivan Tomasi, Lily Dara, Shelly C. Lu, Tony W.H. Li, Pasquale Giordano, Hui Peng, Maria Lauda Tomasi, Yuhua Zheng
Publikováno v:
Hepatology. 57:2299-2313
Methionine adenosyltransferase 2B (MAT2B) encodes for two variant proteins (V1 and V2) that promote cell growth. Using in-solution proteomics, GIT1 (G Protein Coupled Receptor Kinase Interacting ArfGAP 1) was identified as a potential interacting par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::babe4e4f6aadc00895b67cc8afcf01e1
https://doi.org/10.1002/hep.26258
https://doi.org/10.1002/hep.26258
Autor:
Jiaohong Wang, María L. Martínez-Chantar, Wei Fan, Gregory J. Gores, Nirmala Mavila, José M. Mato, Shelly C. Lu, Anuradha Krishnan, Jin Won Yang, Tony W.H. Li, Yuanyuan Tang, Mazen Noureddin, Heping Yang, Jian Tu, Ting Liu, Hui Peng, Alagappan Annamalai
Publikováno v:
Hepatology (Baltimore, Md.), vol 65, iss 4
Prohibitin 1 (PHB1) is best known as a mitochondrial chaperone, and its role in cancer is conflicting. Mice lacking methionine adenosyltransferase α1 (MATα1) have lower PHB1 expression, and we reported that c-MYC interacts directly with both protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac35a5419ca7eb88f411076578683ce
https://pubmed.ncbi.nlm.nih.gov/29053195
https://pubmed.ncbi.nlm.nih.gov/29053195
Autor:
Juan José Lozano, Kwang Suk Ko, Heping Yang, Samuel W. French, Shelly C. Lu, Komal Ramani, Ainhoa Iglesias-Ara, Bangyan L. Stiles, Barbara A. French, Lina He, Tony W.H. Li, José M. Mato, M. Luz Martínez-Chantar, Maria Lauda Tomasi, Pilsoo Oh
Publikováno v:
Hepatology. 52:2096-2108
Prohibitin 1 (PHB1) is a highly conserved, ubiquitously expressed protein that participates in diverse processes including mitochondrial chaperone, growth and apoptosis. The role of PHB1 in vivo is unclear and whether it is a tumor suppressor is cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2322f43d1ce7d4b84895dea4765f882e
https://doi.org/10.1002/hep.23919
https://doi.org/10.1002/hep.23919
Publikováno v:
Hepatology. 51:1291-1301
We previously showed that hepatic expression of glutathione (GSH) synthetic enzymes and GSH levels fell 2 weeks after bile duct ligation (BDL) in mice. This correlated with a switch in nuclear anti-oxidant response element (ARE) binding activity from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff68db6f65633791dab330b8c1902fc9
https://doi.org/10.1002/hep.23471
https://doi.org/10.1002/hep.23471