Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Tony W. J. Cooper"'
Publikováno v:
Angewandte Chemie. 122:8258-8267
Organische Synthesemethoden sind eine treibende Kraft fur die Entwicklung niedermolekularer Wirkstoffe. Die grose Mehrzahl der Medizinalchemiker erhalt zu Beginn – entweder an einer Universitat oder in der Industrie – eine Ausbildung in organisch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e63eaef27a0bf4950d6f05f7cc78191
https://doi.org/10.1002/ange.201002238
https://doi.org/10.1002/ange.201002238
Publikováno v:
Angewandte Chemie International Edition. 49:8082-8091
Synthetic organic reactions are a fundamental enabler of small-molecule drug discovery, and the vast majority of medicinal chemists are initially trained--either at universities or within industry--as synthetic organic chemists. The sheer breadth of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2f57a119d6924a4ac75ab5dacd7e32
https://doi.org/10.1002/anie.201002238
https://doi.org/10.1002/anie.201002238
Autor:
Simon J. F. Macdonald, Graham I. Somers, Natalie Rayner, Tony W. J. Cooper, Iain Mcfarlane Mclay, James Michael Woolven, Simon Taylor, Rosemary Z. Sasse, Gordon G. Weingarten, Diane Mary Coe, Heather A. Barnett, Tracy Jane Shipley, Iain Uings, Phil A. Skone, Torquil I. Jack, Haydn Terence Jones
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:158-162
Aryl aminopyrazole amides capped with N-alkylbenzamides 13-16 are selective glucocorticoid receptor agonists. 2,6-Disubstituted benzamides have prednisolone-like potency or better in vitro. Good oral exposure was demonstrated in the rat, with compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401ca21d58e44b527a101830a268de32
https://doi.org/10.1016/j.bmcl.2008.10.128
https://doi.org/10.1016/j.bmcl.2008.10.128
Autor:
Simon J. F. Macdonald, Philip Alan Skone, Ian B. Campbell, Diane M. Coe, Tony W. J. Cooper, Gordon A. Weingarten, Peter W. Sutton, Deborah Needham, George Hardy, Tracy Jane Shipley, Haydn Terence Jones, Torquil I. Jack, Steven Philip Keeling
Publikováno v:
Tetrahedron Letters. 49:5101-5104
The efficient synthesis of an α-trifluoromethyl-α-tosyloxymethyl epoxide is reported. This highly versatile building block may be reacted sequentially with two different nucleophiles to furnish α-trifluoromethyl tertiary alcohols. Furthermore, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39e5ddf37cef54e5d27b966049701f90
https://doi.org/10.1016/j.tetlet.2008.06.011
https://doi.org/10.1016/j.tetlet.2008.06.011
Publikováno v:
ChemInform. 42
Synthetic organic reactions are a fundamental enabler of small-molecule drug discovery, and the vast majority of medicinal chemists are initially trained--either at universities or within industry--as synthetic organic chemists. The sheer breadth of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13537ebda8c8b3857495ac88f104577b
https://doi.org/10.1002/chin.201106227
https://doi.org/10.1002/chin.201106227
Autor:
Diane M. Coe, David House, Hawa Diallo, Davina C. Angell, Heather A. Barnett, Steve Keeling, Iain M. McLay, Andy Craven, Simon J. F. Macdonald, Tony W. J. Cooper, Torquil I. Jack, Keith Biggadike, Simon Taylor, Samuel Oliver, Iain Uings, James Gray, Natalie Wellaway
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(4)
A novel series of indazole non-steroidal glucocorticoid receptor agonist has been discovered. This series features a sulfonamide central core and meta amides which interact with the extended ligand binding domain. This series has produced some of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4787d650b1bd623c9d2c0dabec5e4b3
https://pubmed.ncbi.nlm.nih.gov/21257309
https://pubmed.ncbi.nlm.nih.gov/21257309
Autor:
Diane M. Coe, Thuy B. Tran, Keith Biggadike, Simon J. F. Macdonald, David House, Iain M. McLay, Randy K. Bledsoe, Tony W. J. Cooper, Simon Taylor, Kevin P. Madauss, Victoria Weller, Tracy Jane Shipley, Iain Uings, Shawn P. Williams, Marie A. Iannone
Crystallography and computer modeling have been used to exploit a previously unexplored channel in the glucocorticoid receptor (GR). Highly potent, nonsteroidal indazole amides showing excellent complementarity to the channel were designed with the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec3491798f2f73e2823f3fc5628edc7
https://europepmc.org/articles/PMC2775345/
https://europepmc.org/articles/PMC2775345/
