Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Tony W Dean"'
Autor:
Patricia F Medeiros, Mythily Vimal, Vipulkumar Kantibhai Patel, John Evans, Neil R Carlson, Antonia J. Lewis, Paul Bamborough, Katherine L Jones, Jane E Smith, Michael O'Sullivan, Scott McCleary, Darren J. Mitchell, Heather Barnett, Chun-wa Chung, Gang Yao, Anthony W. J. Cooper, Rab K. Prinjha, Laurie Gordon, Mahnoor Mahmood, Peter D. Craggs, Isobel L Harada, Rino A Bit, Natalie Wellaway, Armelle Le Gall, Robert J. Watson, Tony W Dean, Dominique Amans, Ian D. Wall, Kayleigh A J Stafford, Dave Lugo, Matthew J Lindon, Rishi R Shah, David Jonathan Hirst, Chris Patten, Darren L Poole, Jack A Brown, Philip G Humphreys, Robert P Davis, Christopher Roland Wellaway, Pamela J Thomas
Publikováno v:
Journal of Medicinal Chemistry. 63:714-746
The bromodomain and extraterminal (BET) family of bromodomain-containing proteins are important regulators of the epigenome through their ability to recognize N-acetyl lysine (KAc) post-translational modifications on histone tails. These interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb502737af78aed357d47636c87313d
https://doi.org/10.1021/acs.jmedchem.9b01670
https://doi.org/10.1021/acs.jmedchem.9b01670
Autor:
John Dawson, Michael David Barker, Stuart Holman, Joanne O. Wiseman, Margarete Neu, Lisa E. Ranshaw, Fiona S. Lucas, Duncan S. Holmes, Michael Kranz, Christopher J. Delves, Beth J. Clarke, Woodrow Michael David, Tony W. Dean, Don O. Somers, Steven B. Guntrip, Stuart P. Ballantine, Yemisi E. Solanke, Mika K. Lindvaal, Sharon Lisa Gough, Brian Evans, Ward Peter
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1380-1385
Crystallography driven optimisation of a lead derived from similarity searching of the GSK compound collection resulted in the discovery of quinoline-3-carboxamides as highly potent and selective inhibitors of phosphodiesterase 4B. This series has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d1b7e1eca93eb6425d855b2b8ac1a8
https://doi.org/10.1016/j.bmcl.2009.01.045
https://doi.org/10.1016/j.bmcl.2009.01.045
Autor:
Ryan G. Kruger, Roland S. Annan, Patricia A. Elkins, Tony W. Dean, Patrick McDevitt, Helai P. Mohammad, Francesca Zappacosta, Alan P. Graves, William G. Bonnette, Dai-Shi Su, Glenn S. Van Aller, Christopher L. Carpenter
Publikováno v:
Structure (London, England : 1993). 24(5)
SMYD3 is a lysine methyltransferase overexpressed in colorectal, breast, prostate, and hepatocellular tumors, and has been implicated as an oncogene in human malignancies. Methylation of MEKK2 by SMYD3 is important for regulation of the MEK/ERK pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c014e8bdf029a94d408ffb0ea803a65
https://pubmed.ncbi.nlm.nih.gov/27066749
https://pubmed.ncbi.nlm.nih.gov/27066749
Autor:
Bill Leavens, Jonathan P. Hutchinson, Carl Haslam, Damian J. Mole, John Liddle, Scott P. Webster, Beverley A. Yard, Argyrides Argyrou, Erica Christodoulou, Margaret Binnie, Paul Hissey, P. Hardwicke, Kris Wilson, Denise M. Lowe, Tony W. Dean, Iain Uings, Michelle Gee
Publikováno v:
Journal of biomolecular screening. 19(4)
Kynurenine 3-monooxygenase (KMO) is a therapeutically important target on the eukaryotic tryptophan catabolic pathway, where it converts L-kynurenine (Kyn) to 3-hydroxykynurenine (3-HK). We have cloned and expressed the human form of this membrane pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfd2b2fee2bad3fa1390a14c9721233e
https://pubmed.ncbi.nlm.nih.gov/24381207
https://pubmed.ncbi.nlm.nih.gov/24381207
Autor:
Michael D. Woodrow, Stuart P. Ballantine, Michael D. Barker, Beth J. Clarke, John Dawson, Tony W. Dean, Christopher J. Delves, Brian Evans, Sharon L. Gough, Steven B. Guntrip, Stuart Holman, Duncan S. Holmes, Michael Kranz, Mika K. Lindvaal, Fiona S. Lucas, Margarete Neu, Lisa E. Ranshaw, Yemisi E. Solanke, Don O. Somers, Peter Ward, Joanne O. Wiseman
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(17)
Crystallography driven optimisation of a lead derived from similarity searching of the GSK compound collection resulted in the discovery of quinoline-3-carboxamides as highly potent and selective inhibitors of phosphodiesterase 4B. This series has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::183db6b3496dd28055dbc18b1fc971c2
https://pubmed.ncbi.nlm.nih.gov/19656678
https://pubmed.ncbi.nlm.nih.gov/19656678
Autor:
Simon J. Dowell, Andrew J. Brown, Forhad Chowdhury, Nicolas Faucher, Tony W. Dean, Elaine Gower, Nisha Bhudia, Emma Ward, Christina Tsoulou, Akanksha Gangar
Publikováno v:
Pharmacology Research & Perspectives
FFA2 is a receptor for short-chain fatty acids. Propionate (C3) and 4-chloro-α-(1-methylethyl)-N-2-thiazolyl-benzeneacetamide (4-CMTB), the prototypical synthetic FFA2 agonist, evoke calcium mobilization in neutrophils and inhibit lipolysis in adipo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b832bd404e7c9e91876819f81394441
https://doi.org/10.1002/prp2.141
https://doi.org/10.1002/prp2.141
Publikováno v:
Journal of the American Chemical Society. 128(19)
Polystyrene-poly(ethylene glycol) resin-captured cross-linked palladium nanopaticles were prepared via a straightforward route, and their heterogeneous behavior was truly confirmed by various tests. They were applied to aqueous Suzuki cross-coupling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba81a9df5ac0c1d1acf58ef9972bcfa
https://pubmed.ncbi.nlm.nih.gov/16683766
https://pubmed.ncbi.nlm.nih.gov/16683766
Publikováno v:
Chemical Communications. :1470
pH indicating resins were prepared by covalently attaching carboxylic acid derivatives of sulfthalein dyes, synthesized using a Suzuki cross-coupling, onto resin beads. The resin-bound indicators showed the expected colour changes according to pH and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387a00c71b3d521821463e092ee5ab34
https://doi.org/10.1039/b405198j
https://doi.org/10.1039/b405198j
Publikováno v:
Chemical Communications. :502
Self-indicating methylisocyanate resin, which functions as both a scavenger and an indicator for amines, was used for in-situ reaction monitoring and purification of a urea based library.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c424eed7414a914eda89ac80d4361b31
https://doi.org/10.1039/b315426b
https://doi.org/10.1039/b315426b
Publikováno v:
Scopus-Elsevier
A novel strategy for the synthesis of oligosaccharides, involving the use of a solid phase peptide template, has been successfully applied to the construction of a twelve member disaccharide library.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54102414d0a4ade5181686efc5c60898
http://www.scopus.com/inward/record.url?eid=2-s2.0-1442276300&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-1442276300&partnerID=MN8TOARS
