Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Tony Ton"'
Autor:
Timothy D. Owens, Ken A. Brameld, Erik J. Verner, Tony Ton, Xiaoyan Li, Jiang Zhu, Mohammad R. Masjedizadeh, J. Michael Bradshaw, Ronald J. Hill, Danny Tam, Angelina Bisconte, Eun Ok Kim, Michelle Francesco, Yan Xing, Jin Shu, Dane Karr, Jacob LaStant, David Finkle, Natalie Loewenstein, Helena Haberstock-Debic, Michael J. Taylor, Philip Nunn, Claire L. Langrish, David M. Goldstein
Publikováno v:
Journal of medicinal chemistry. 65(7)
Bruton's tyrosine kinase (BTK), a Tec family tyrosine kinase, is critical in immune pathways as an essential intracellular signaling element, participating in both adaptive and immune responses. Currently approved BTK inhibitors are irreversible cova
Autor:
Edward Brainard Pranata, Tony Tony
Publikováno v:
Journal of Information Systems and Informatics, Vol 6, Iss 1, Pp 378-398 (2024)
E-commerce has become common and important for businesses, but Jaya Sentosa Store has not implemented it. E-commerce commonly has only a search by keyword feature, but that cannot replicate Jaya Sentosa Store order process. An image-based search is n
Externí odkaz:
https://doaj.org/article/cfadce7fd513476db4d16edd59be32b5
Autor:
Enzo Viana Maraschin, Leandro Timoni Buchdid Camargo Neves, Tony Tonny Nascimento Gomes, Wismith Silva de Andrade, Sara Caroline Prill Gomes, Ozimar de Lima Coutinho, Hestarlem Pietro de Andrade Guimarães
Publikováno v:
Agro@mbiente On-line, Vol 18, Iss 00 (2024)
In Roraima, banana cultivation is a significant socio-economic activity aimed at catering to both the domestic and regional markets. The banana-producing region (Musa spp) is concentrated in the southern part of the state, encompassing the municipali
Externí odkaz:
https://doaj.org/article/e47422a812a54f718db9e61a47dfc670
Autor:
Owens, Timothy D., Brameld, Ken A., Verner, Erik J., Tony Ton, Xiaoyan Li, Jiang Zhu, Masjedizadeh, Mohammad R., Bradshaw, J. Michael, Hill, Ronald J., Danny Tam, Bisconte, Angelina, Eun Ok Kim, Francesco, Michelle, Yan Xing, Jin Shu, Karr, Dane, LaStant, Jacob, Finkle, David, Loewenstein, Natalie, Haberstock-Debic, Helena
Publikováno v:
Journal of Medicinal Chemistry; 4/14/2022, Vol. 65 Issue 7, p5300-5316, 17p
Autor:
Mary E. Gerritsen, Dane Karr, Ken A. Brameld, Timothy D. Owens, Vernon T. Phan, Jens Oliver Funk, Eleni Venetsanakos, David G. Loughhead, Tony Ton, Danny Tam, David Michael Goldstein, Erik Verner, Jin Shu, Kwan Leung, Jacob LaStant, J. Michael Bradshaw
Publikováno v:
Journal of Medicinal Chemistry. 60:6516-6527
Aberrant signaling of the FGF/FGFR pathway occurs frequently in cancers and is an oncogenic driver in many solid tumors. Clinical validation of FGFR as a therapeutic target has been demonstrated in bladder, liver, lung, breast, and gastric cancers. O
Autor:
Amanda Mathis, Wenyan Mo, Susan Long, Stephanie Anna Chan, Jill Walker, Ryan Lauchli, Martin Robert Leivers, Elizabeth M. Turner, Tony Ton, Sebastian Liehr, J. Greg Falls, John F. Miller, Michael Youngman
Publikováno v:
Journal of Medicinal Chemistry. 57:1964-1975
By reducing the basicity of the core heterocycle in a series of HCV NS5B inhibitors, the hERG liability was reduced. The SAR was then systematically explored in order to increase solubility and enable dose escalation while retaining potency. During t
Autor:
Huiyong Hu, Barry Patrick Hart, Roopa Rai, Michael J. Green, Ravi Rajagopalan, Yu M. Xia, Joseph D. Ho, John R. Somoza, Isabelle Lehoux, Dange Vijay Kumar, Jennifer Riggs, Ken A. Brameld, James W. Janc, Tony Ton, Wendy B. Young
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:300-304
The discovery and optimization of a novel class of quinolone small-molecules that inhibit NS5B polymerase, a key enzyme of the HCV viral life-cycle, is described. Our research led to the replacement of a hydrolytically labile ester functionality with
Autor:
Timothy D. Owens, Mary E. Gerritsen, Ronald J. Hill, David G Loughhead, J. Michael Bradshaw, Erik Verner, Dane Karr, David Michael Goldstein, Jesse M. McFarland, Vernon T. Phan, Angelina Bisconte, Vaishali Patel, Philip A. Nunn, Jens Oliver Funk, Jin Shu, David Finkle, Danny Tam, Tony Ton, Ken A. Brameld, Ville O. Paavilainen, Xiaoyan Li, Jack Taunton, Sergei Romanov
Publikováno v:
Nature chemical biology, vol 11, iss 7
Nature chemical biology
Nature chemical biology
Drugs with prolonged, on-target residence time often show superior efficacy, yet general strategies for optimizing drug-target residence time are lacking. Here, we demonstrate progress toward this elusive goal by targeting a noncatalytic cysteine in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83acadbd6e4eba9e99e2adc9c4909438
https://escholarship.org/uc/item/45z2k97q
https://escholarship.org/uc/item/45z2k97q
Autor:
Ellen Sanford, Roopa Rai, Steven M. Torkelson, William D. Shrader, Ronnell Cabuslay, Bradley A. Katz, Paul A. Sprengeler, Tony Ton, Aleksandr Kolesnikov, Robin Stephens, Wendy B. Young, Christine Yu, John Hendrix
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2270-2273
Structure-activity relationships and binding mode of novel heterocyclic factor VIIa inhibitors will be described. In these inhibitors, a highly basic 5-amidinoindole moiety has been successfully replaced with a less basic 5-aminopyrrolo[3,2-b]pyridin
Autor:
Dai-Lun Chiang, Sheng-Kuan Wang, Yi-Nan Lin, Cheng-Ying Yang, Victor R.L. Shen, Tony Tong-Ying Juang, Ting-Yi Liao
Publikováno v:
Applied Artificial Intelligence, Vol 35, Iss 14, Pp 1169-1195 (2021)
More and more people are entering the cryptocurrency market after Bitcoin (BTC) soared to nearly USD 20,000 in 2017. To promote the development of information technology and cryptocurrency marketing, various computerized systems integrating informati
Externí odkaz:
https://doaj.org/article/b9859fd36e4742fdac4c4f1724ba33e6