Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Tony Taldone"'
Autor:
Anna Rodina, Chao Xu, Chander S. Digwal, Suhasini Joshi, Yogita Patel, Anand R. Santhaseela, Sadik Bay, Swathi Merugu, Aftab Alam, Pengrong Yan, Chenghua Yang, Tanaya Roychowdhury, Palak Panchal, Liza Shrestha, Yanlong Kang, Sahil Sharma, Justina Almodovar, Adriana Corben, Mary L. Alpaugh, Shanu Modi, Monica L. Guzman, Teng Fei, Tony Taldone, Stephen D. Ginsberg, Hediye Erdjument-Bromage, Thomas A. Neubert, Katia Manova-Todorova, Meng-Fu Bryan Tsou, Jason C. Young, Tai Wang, Gabriela Chiosis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-26 (2023)
Abstract Systems-level assessments of protein-protein interaction (PPI) network dysfunctions are currently out-of-reach because approaches enabling proteome-wide identification, analysis, and modulation of context-specific PPI changes in native (unen
Externí odkaz:
https://doaj.org/article/bd99358101954a8492861b762bbf8146
Autor:
Suhasini Joshi, Erica DaGama Gomes, Tai Wang, Adriana Corben, Tony Taldone, Srinivasa Gandu, Chao Xu, Sahil Sharma, Salma Buddaseth, Pengrong Yan, Lon Yin L. Chan, Askan Gokce, Vinagolu K. Rajasekhar, Lisa Shrestha, Palak Panchal, Justina Almodovar, Chander S. Digwal, Anna Rodina, Swathi Merugu, NagaVaraKishore Pillarsetty, Vlad Miclea, Radu I. Peter, Wanyan Wang, Stephen D. Ginsberg, Laura Tang, Marissa Mattar, Elisa de Stanchina, Kenneth H. Yu, Maeve Lowery, Olivera Grbovic-Huezo, Eileen M. O’Reilly, Yelena Janjigian, John H. Healey, William R. Jarnagin, Peter J. Allen, Chris Sander, Hediye Erdjument-Bromage, Thomas A. Neubert, Steven D. Leach, Gabriela Chiosis
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-20 (2021)
Joshi, Gomes et al. employ a chemical modulation approach of the cellular interactome to a hyperconnectivity state and show association with the increased response of pancreatic cancer cell lines to specific drugs, including those that target the MAP
Externí odkaz:
https://doaj.org/article/c73d69998238486ba39d6f85c901b64d
Autor:
Alexander Bolaender, Danuta Zatorska, Huazhong He, Suhasini Joshi, Sahil Sharma, Chander S. Digwal, Hardik J. Patel, Weilin Sun, Brandon S. Imber, Stefan O. Ochiana, Maulik R. Patel, Liza Shrestha, Smit. K. Shah, Shuo Wang, Rashad Karimov, Hui Tao, Pallav D. Patel, Ananda Rodilla Martin, Pengrong Yan, Palak Panchal, Justina Almodovar, Adriana Corben, Andreas Rimner, Stephen D. Ginsberg, Serge Lyashchenko, Eva Burnazi, Anson Ku, Teja Kalidindi, Sang Gyu Lee, Milan Grkovski, Bradley J. Beattie, Pat Zanzonico, Jason S. Lewis, Steve Larson, Anna Rodina, Nagavarakishore Pillarsetty, Viviane Tabar, Mark P. Dunphy, Tony Taldone, Fumiko Shimizu, Gabriela Chiosis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Here, the authors show structural, biochemical, and functional insights into the discovery of epichaperome‐ directed chemical probes for use in central nervous system diseases. Probes emerging from this work have translated to human clinical studie
Externí odkaz:
https://doaj.org/article/ed3d8f0c921541cb8291f5f96c64889e
Autor:
Maria Carmen Inda, Suhasini Joshi, Tai Wang, Alexander Bolaender, Srinivasa Gandu, John Koren III, Alicia Yue Che, Tony Taldone, Pengrong Yan, Weilin Sun, Mohammad Uddin, Palak Panchal, Matthew Riolo, Smit Shah, Afsar Barlas, Ke Xu, Lon Yin L. Chan, Alexandra Gruzinova, Sarah Kishinevsky, Lorenz Studer, Valentina Fossati, Scott A. Noggle, Julie R. White, Elisa de Stanchina, Sonia Sequeira, Kyle H. Anthoney, John W. Steele, Katia Manova-Todorova, Sujata Patil, Mark P. Dunphy, NagaVaraKishore Pillarsetty, Ana C. Pereira, Hediye Erdjument-Bromage, Thomas A. Neubert, Anna Rodina, Stephen D. Ginsberg, Natalia De Marco Garcia, Wenjie Luo, Gabriela Chiosis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
The biology of Alzheimer’s disease (AD) remains unknown. We propose AD is a protein connectivity-based dysfunction disorder whereby a switch of the chaperome into epichaperomes rewires proteome-wide connectivity, leading to brain circuitry malfunct
Externí odkaz:
https://doaj.org/article/c776838301d2406eb50617b6e0cb86a1
Autor:
Pengrong Yan, Hardik J. Patel, Sahil Sharma, Adriana Corben, Tai Wang, Palak Panchal, Chenghua Yang, Weilin Sun, Thais L. Araujo, Anna Rodina, Suhasini Joshi, Kenneth Robzyk, Srinivasa Gandu, Julie R. White, Elisa de Stanchina, Shanu Modi, Yelena Y. Janjigian, Elizabeth G. Hill, Bei Liu, Hediye Erdjument-Bromage, Thomas A. Neubert, Nanette L.S. Que, Zihai Li, Daniel T. Gewirth, Tony Taldone, Gabriela Chiosis
Publikováno v:
Cell Reports, Vol 31, Iss 13, Pp 107840- (2020)
Summary: Stresses associated with disease may pathologically remodel the proteome by both increasing interaction strength and altering interaction partners, resulting in proteome-wide connectivity dysfunctions. Chaperones play an important role in th
Externí odkaz:
https://doaj.org/article/578f1f10d35b40649e20dfe6b20c31b8
Autor:
Sarah Kishinevsky, Tai Wang, Anna Rodina, Sun Young Chung, Chao Xu, John Philip, Tony Taldone, Suhasini Joshi, Mary L. Alpaugh, Alexander Bolaender, Simon Gutbier, Davinder Sandhu, Faranak Fattahi, Bastian Zimmer, Smit K. Shah, Elizabeth Chang, Carmen Inda, John Koren, Nathalie G. Saurat, Marcel Leist, Steven S. Gross, Venkatraman E. Seshan, Christine Klein, Mark J. Tomishima, Hediye Erdjument-Bromage, Thomas A. Neubert, Ronald C. Henrickson, Gabriela Chiosis, Lorenz Studer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
The early molecular events that ultimately lead to neuronal cell death in pathologies such as Parkinson’s disease are poorly understood. Here the authors use pluripotent stem-cell-derived human midbrain neurons and chemical biology tools to gain mo
Externí odkaz:
https://doaj.org/article/58327b67c3514927a9a253f4bd3c8f1f
Autor:
Sun Young Chung, Sarah Kishinevsky, Joseph R. Mazzulli, John Graziotto, Ana Mrejeru, Eugene V. Mosharov, Lesly Puspita, Parvin Valiulahi, David Sulzer, Teresa A. Milner, Tony Taldone, Dimitri Krainc, Lorenz Studer, Jae-won Shim
Publikováno v:
Stem Cell Reports, Vol 7, Iss 4, Pp 664-677 (2016)
Parkinson's disease (PD) is characterized by the selective loss of dopamine neurons in the substantia nigra; however, the mechanism of neurodegeneration in PD remains unclear. A subset of familial PD is linked to mutations in PARK2 and PINK1, which l
Externí odkaz:
https://doaj.org/article/a501ca37f14940beb9ce6026a56a7725
Autor:
Hongliang Zong, Alexander Gozman, Eloisi Caldas-Lopes, Tony Taldone, Eric Sturgill, Sarah Brennan, Stefan O. Ochiana, Erica M. Gomes-DaGama, Siddhartha Sen, Anna Rodina, John Koren III, Michael W. Becker, Charles M. Rudin, Ari Melnick, Ross L. Levine, Gail J. Roboz, Stephen D. Nimer, Gabriela Chiosis, Monica L. Guzman
Publikováno v:
Cell Reports, Vol 13, Iss 10, Pp 2159-2173 (2015)
Acute myeloid leukemia (AML) is a heterogeneous and fatal disease with an urgent need for improved therapeutic regimens given that most patients die from relapsed disease. Irrespective of mutation status, the development of aggressive leukemias is en
Externí odkaz:
https://doaj.org/article/03d9a17749844c7d85caa19fad88d006
Autor:
Tony Taldone, Anna Rodina, Erica M. DaGama Gomes, Matthew Riolo, Hardik J. Patel, Raul Alonso-Sabadell, Danuta Zatorska, Maulik R. Patel, Sarah Kishinevsky, Gabriela Chiosis
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 544-556 (2013)
The attachment of biotin to a small molecule provides a powerful tool in biology. Here, we present a systematic approach to identify biotinylated analogues of the Hsp90 inhibitor PU-H71 that are capable of permeating cell membranes so as to enable th
Externí odkaz:
https://doaj.org/article/ae69e2f107394319996e7fbd51d6e4ce
A purine analog synergizes with chloroquine (CQ) by targeting Plasmodium falciparum Hsp90 (PfHsp90).
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75446 (2013)
Drug resistance, absence of an effective vaccine, and inadequate public health measures are major impediments to controlling Plasmodium falciparum malaria worldwide. The development of antimalarials to which resistance is less likely is paramount. To
Externí odkaz:
https://doaj.org/article/e00135dd0c5843609fceb70d18ee9142