Spatial transcriptomic analysis reveals local effects of intratumoral fusobacterial infection on DNA damage and immune signaling in rectal cancer

Autor: William P. Duggan, Batuhan Kisakol, Ina Woods, Mohammedreza Azimi, Heiko Dussmann, Joanna Fay, Tony O’Grady, Barry Maguire, Ian S. Reynolds, Manuela Salvucci, Daniel J. Slade, Deborah A. McNamara, John P. Burke, Jochen H.M. Prehn

Publikováno v: Gut Microbes, Vol 16, Iss 1 (2024)

ABSTRACTMucinous colorectal cancer (CRC) is a common histological subtype of colorectal adenocarcinoma, associated with a poor response to chemoradiotherapy. The commensal facultative anaerobes fusobacteria, have been associated with poor prognosis s

Externí odkaz: https://doaj.org/article/2b11e6dc763e4a1aacdfb8cd8e2a82f3

Increased Fusobacterium tumoural abundance affects immunogenicity in mucinous colorectal cancer and may be associated with improved clinical outcome

Autor: William P. Duggan, Manuela Salvucci, Batuhan Kisakol, Andreas U. Lindner, Ian S. Reynolds, Heiko Dussmann, Joanna Fay, Tony O’Grady, Daniel B. Longley, Fiona Ginty, Elizabeth Mc Donough, Daniel J. Slade, John P. Burke, Jochen H. M. Prehn

Publikováno v: Duggan, W P, Salvucci, M, Kisakol, B, Lindner, A U, Reynolds, I S, Dussmann, H, Fay, J, O'Grady, T, Longley, D B, Ginty, F, Mc Donough, E, Slade, D J, Burke, J P & Prehn, J H M 2023, ' Increased Fusobacterium tumoural abundance affects immunogenicity in mucinous colorectal cancer and may be associated with improved clinical outcome ', Journal of Molecular Medicine . https://doi.org/10.1007/s00109-023-02324-5

Abstract There is currently an urgent need to identify factors predictive of immunogenicity in colorectal cancer (CRC). Mucinous CRC is a distinct histological subtype of CRC, associated with a poor response to chemotherapy. Recent evidence suggests

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b381d73c33c46ad0beb774487fa985d
https://doi.org/10.1007/s00109-023-02324-5

Data from Challenging the Cancer Molecular Stratification Dogma: Intratumoral Heterogeneity Undermines Consensus Molecular Subtypes and Potential Diagnostic Value in Colorectal Cancer

Autor: Sandra Van Schaeybroeck, Manuel Salto-Tellez, Mark Lawler, Patrick G. Johnston, Elaine W. Kay, Daniel B. Longley, Peter W. Hamilton, David J. Waugh, Simon S. McDade, Wendy L. Allen, Maurice B. Loughrey, Ken Arthur, Tony O'Grady, Robert Cummins, Helen L. Barrett, Paul G. O'Reilly, Conor A. Bradley, Darragh G. McArt, Philip D. Dunne

Purpose: A number of independent gene expression profiling studies have identified transcriptional subtypes in colorectal cancer with potential diagnostic utility, culminating in publication of a colorectal cancer Consensus Molecular Subtype classifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2659102c09a5860345e0b7360d9dc6f3
https://doi.org/10.1158/1078-0432.c.6525305

Supplementary Table 3 from Challenging the Cancer Molecular Stratification Dogma: Intratumoral Heterogeneity Undermines Consensus Molecular Subtypes and Potential Diagnostic Value in Colorectal Cancer

Autor: Sandra Van Schaeybroeck, Manuel Salto-Tellez, Mark Lawler, Patrick G. Johnston, Elaine W. Kay, Daniel B. Longley, Peter W. Hamilton, David J. Waugh, Simon S. McDade, Wendy L. Allen, Maurice B. Loughrey, Ken Arthur, Tony O'Grady, Robert Cummins, Helen L. Barrett, Paul G. O'Reilly, Conor A. Bradley, Darragh G. McArt, Philip D. Dunne

Supplementary Table 3: Differentially expressed gene list contrasting tumour region of origin between Central Tumor and Lymph Node.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8012106cb0155e673bef078d6e9977f0
https://doi.org/10.1158/1078-0432.22463087.v1

Abstract 5787: Modelling the spatial heterogeneity of CD45-positive tumor infiltrating lymphocytes in early-stage, estrogen receptor-positive breast cancer

Autor: Zak Kinsella, Anna Blümel, Mairi Lucas, Andreas Lindner, Claudia A. Gonzalez, Arman Rahman, Joanna Fay, Tony O'Grady, Verena Murphy, John Crown, Cathy Kelly, William Gallagher, Darran O'Connor

Publikováno v: Cancer Research. 83:5787-5787

The frequency of lymphocytes infiltrating tumors is a known prognostic in estrogen receptor (ER) negative cancers. ER+ disease is putatively believed to be immune cold, however, there exists a subset of ER+ tumors with high immune infiltrate and with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e9907e6ce7ffa8447fcc3da5d587c0ba
https://doi.org/10.1158/1538-7445.am2023-5787