Temozolomide, Gemcitabine, and Decitabine Hybrid Nanoconjugates: From Design to Proof-of-Concept (PoC) of Synergies toward the Understanding of Drug Impact on Human Glioblastoma Cells

Autor: Philippe Savarin, Jolanda Spadavecchia, Manon Courcelle, Ferdaous Sahli, Tony Lionel Palama, Nadia Djaker

Publikováno v: Journal of Medicinal Chemistry. 63:7410-7421

This paper emphasizes the synthesis of novel hybrid drug nanoparticles (Hyb-D-AuNPs) based on gold-temozolomide (TMZ) complexes combined with gemcitabine (GEM) and decitabine (DAC) to improve the efficiency and reduce the resistance of U87 malignant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343d4d29daa320f372bfa5640f5ee628
https://doi.org/10.1021/acs.jmedchem.0c00694

Discrimination of Escherichia coli and Shigella spp. by Nuclear Magnetic Resonance Based Metabolomic Characterization of Culture Media

Autor: Isabelle Canard, Gilles J. P. Rautureau, Sonia Chatellier, Bénédicte Elena-Herrmann, Tony Lionel Palama, Alex van Belkum, Caroline Mirande

Publikováno v: ACS Infectious Diseases
ACS Infectious Diseases, American Chemical Society, 2019, ⟨10.1021/acsinfecdis.9b00199⟩
ACS Infectious Diseases, 2019, 5 (11), pp.1879-1886. ⟨10.1021/acsinfecdis.9b00199⟩

International audience; Dysentery is a major health threat that dramatically impacts childhood morbidity and mortality in developing countries. Various pathogenic agents cause dysentery, such as Shigella spp. and Escherichia coli, which are very clos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c12ab17906a106662889dcae66e9334
https://doi.org/10.1021/acsinfecdis.9b00199

Targeting the mitochondrial trifunctional protein restrains tumor growth in oxidative lung carcinomas

Autor: Isabelle Redonnet-Vernhet, Nadège Bellance, Floriant Bellvert, Matthieu Thumerel, Nathalie Dugot-Senan, Mariana Figueiredo Rodrigues, Hamid Reza Rezvani, Hugues Begueret, Elodie Dumon, Fatima Mechta-Grigoriou, Rodrigue Rossignol, Didier Lacombe, Pauline Esteves, Giuseppe Punzi, Yann Kieffer, Julien Izotte, Nivea Dias Amoedo, Ciro Leonardo Pierri, Tony Lionel Palama, Saharnaz Sarlak, Benoit Rousseau, Jean-Marc Baste, Lara Gales, Stéphane Claverol, Emilie Obre, Alexis Dupis, Laetitia Dard, Véronique Guyonnet-Duperat, Walid Mafhouf

Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 2021, 131 (1), ⟨10.1172/JCI133081⟩
Journal of Clinical Investigation, 2021, 131 (1), ⟨10.1172/JCI133081⟩
J Clin Invest

International audience; Metabolic reprogramming is a common hallmark of cancer, but a large variability in tumor bioenergetics exists between patients. Using high-resolution respirometry on fresh biopsies of human lung adenocarcinoma, we identified 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18a7223aecb6d054c8da7a0d4624e88
https://hal.inrae.fr/hal-03131394

Identification of bacterial species by untargeted NMR spectroscopy of the exo-metabolome

Autor: Gilles J. P. Rautureau, Isabelle Canard, Tony Lionel Palama, Bénédicte Elena-Herrmann, Sonia Chatellier, Caroline Mirande

Publikováno v: Analyst
Analyst, Royal Society of Chemistry, 2016, 141, pp.4558-4561. ⟨10.1039/C6AN00393A⟩

International audience; Identification of bacterial species is a crucial bottleneck for clinical diagnosis of infectious diseases. Quick and reliable identification is a key factor to provide suitable antibiotherapies and avoid the development of mul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1b3ce62c52ee39f2df2d393e5fe9302
https://doi.org/10.1039/c6an00393a

IDH1 Mutation Enhances Catabolic Flexibility and Mitochondrial Dependencies to Favor Drug Resistance in Acute Myeloid Leukemia

Autor: Héléna Boutzen, Clément Larrue, Pierre Millard, Laurent Fernando, Laurent Le Cam, Laurie Gayte, Noémie Gadaud, Tony Kaoma, Pierre-Luc Mouchel, Evgenia Turtoi, Jean-Charles Portais, Nesrine Aroua, Justine Bertrand-Michel, Courtney Dinardo, Tony Lionel Palama, Yves Collette, Camille Montersino, Laure Tonini, Yves Gibon, Madi Y. Cissé, Cédric Cassan, Koichi Takahashi, Florence Castelli, Pierre Bories, Audrey Bidet, Joe Marszalek, Martin Carroll, Guillaume Cazals, Claire Calmettes, Arnaud Pigneux, Thomas Farge, Lucille Stuani, Feng Wang, Fabien Jourdan, Laetitia K. Linares, Mary A. Selak, Lara Gales, Andrew M. Futreal, Mathilde Gotanègre, Maud Heuillet, Kiyomi Morita, Jean-Emmanuel Sarry, Andrei Turtoi, Nicolas Broin, Christian Recher, Marina Konopleva, Mohsen Hosseini, Christophe Junot, Claudie Bosc, Emeline Chu-Van, Marine Fraisse, Nathalie Saint-Laurent, Lindsay Peyriga, Rémy Castellano, Estelle Saland, Natalia Baran, Norbert Vey, Frédéric Lopez, Floriant Bellvert, Marie Sabatier, Nathalie Poupin

Publikováno v: SSRN Electronic Journal.

Isocitrate dehydrogenases (IDH) are involved in redox control and central metabolism. We hypothesized that key metabolic fluxes are selectively reprogrammed to maintain biosynthetic homeostasis and lower drug responses in IDH mutant acute myeloid leu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1ba1581b47f07f178516f5bad74221b
https://doi.org/10.2139/ssrn.3255557