Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Tony L. Parkes"'
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 8, Pp 2651-2664 (2017)
Mutations often have drastically different effects in different genetic backgrounds; understanding a gene’s biological function then requires an understanding of its interaction with genetic diversity. The antioxidant enzyme cytosolic copper/zinc s
Externí odkaz:
https://doaj.org/article/26c3a31ff004427c9eba2ff7f9adf659
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24518 (2011)
The response to oxidative stress involves numerous genes and mutations in these genes often manifest in pleiotropic ways that presumably reflect perturbations in ROS-mediated physiology. The Drosophila melanogaster SOD1-null allele (cSODn108) is prop
Externí odkaz:
https://doaj.org/article/7f0c6a2e0844401480d3f5db0158491f
Autor:
Jose M. Knee, Thomas J.S. Merritt, Tony L. Parkes, Liang Li, Teresa Z. Rzezniczak, Marney L. Doran, Nan Wang
Publikováno v:
Free Radical Biology and Medicine. 113:323-334
Oxidative stress results in substantial biochemical and physiological perturbations in essentially all organisms. To determine the broad metabolic effects of oxidative stress, we have quantified the response in Drosophila melanogaster to both genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de5a4c25e3e90561b19389afd8357043
https://doi.org/10.1016/j.freeradbiomed.2017.10.011
https://doi.org/10.1016/j.freeradbiomed.2017.10.011
Publikováno v:
G3: Genes|Genomes|Genetics
G3: Genes, Genomes, Genetics, Vol 7, Iss 8, Pp 2651-2664 (2017)
G3: Genes, Genomes, Genetics, Vol 7, Iss 8, Pp 2651-2664 (2017)
Mutations often have drastically different effects in different genetic backgrounds; understanding a gene’s biological function then requires an understanding of its interaction with genetic diversity. The antioxidant enzyme cytosolic copper/zinc s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d1f3871b201817b2346f285fd222817
http://europepmc.org/articles/PMC5555470
http://europepmc.org/articles/PMC5555470
Publikováno v:
Experimental Gerontology. 35:1157-1164
Earlier studies from this laboratory have shown that in the insect, Drosophila melanogaster, the motorneuron is an important cellular nexus between the metabolism of reactive oxygen species (ROS) and adult lifespan. This was demonstrated by experimen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f456846aa50f53a79e46b072ba5091
https://doi.org/10.1016/s0531-5565(00)00117-0
https://doi.org/10.1016/s0531-5565(00)00117-0
Publikováno v:
Journal of Neurogenetics. 14:193-205
Genetic loci that influence behavior are often difficult to identify and localize in part due to the quantitative nature of behavioral phenotypes. Previous studies had found an association between pupal lethality and altered larval behavior for mutan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c264ee415dabf277fd6af3ca9e51c4b5
https://doi.org/10.3109/01677060009084498
https://doi.org/10.3109/01677060009084498
Autor:
Tony L. Parkes, Peter St, John P. Phillips, Kim Kirby, Arthur J. Hilliker, George-HyslopGabrielle L Boulianne, Andrew J. Elia
Publikováno v:
Free Radical Biology and Medicine. 26:1332-1338
Mutations in human CuZn superoxide dismutase (SOD) have been associated with familial amyotrophic lateral sclerosis (FALS). Although leading to many experimental advances, this finding has not yet led to a clear understanding of the biochemical mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db671db805e0740571283c628b6c5882
https://doi.org/10.1016/s0891-5849(98)00333-5
https://doi.org/10.1016/s0891-5849(98)00333-5
Publikováno v:
Genome. 41:642-651
Cu-Zn superoxide dismutase (cSOD) is an enzyme of critical importance for the inactivation of superoxide radicals generated by cellular metabolic processes. A phenotypic syndrome has been characterized for homozygotes for a null mutation of the Droso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63c0ff0002a78cff268a38b6c308be31
https://doi.org/10.1139/g98-068
https://doi.org/10.1139/g98-068
Autor:
Andrew J. Elia, John P. Phillips, Gabrielle L. Boulianne, Dale A. Dickinson, Arthur J. Hilliker, Tony L. Parkes
Publikováno v:
Nature Genetics. 19:171-174
Reactive oxygen (RO) has been identified as an important effector in ageing and lifespan determination1,2,3. The specific cell types, however, in which oxidative damage acts to limit lifespan of the whole organism have not been explicitly identified.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9694b99f04673e9336d3f0cb6c5a1b52
https://doi.org/10.1038/534
https://doi.org/10.1038/534
Autor:
Tony L. Parkes, John P. Phillips, Xiaodong Wang, Arthur J. Hilliker, Kim Kirby, Gabreille L. Boulianne, Atanu Duttaroy, Peter C. R. Emtage
Publikováno v:
DNA and Cell Biology. 16:391-399
The gene encoding manganese superoxide dismutase (MnSOD) from Drosophila melanogaster has been isolated and its expression has been studied. In contrast to several mammalian MnSOD genes, the Drosophila gene contains a single intron and is transcribed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c49f8ced28e8543efe7e8dc4acbcb783
https://doi.org/10.1089/dna.1997.16.391
https://doi.org/10.1089/dna.1997.16.391