Zobrazeno 1 - 10
of 321
pro vyhledávání: '"Tony Kwan"'
Autor:
Platon Megagiannis, Yuan Mei, Rachel E. Yan, Lin Yuan, Jonathan J. Wilde, Hailey Eckersberg, Rahul Suresh, Xinzhu Tan, Hong Chen, W. Todd Farmer, Kuwook Cha, Phuong Uyen Le, Helene Catoire, Daniel Rochefort, Tony Kwan, Brian A. Yee, Patrick Dion, Arjun Krishnaswamy, Jean-Francois Cloutier, Stefano Stifani, Kevin Petrecca, Gene W. Yeo, Keith K. Murai, Guoping Feng, Guy A. Rouleau, Trey Ideker, Neville E. Sanjana, Yang Zhou
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114637- (2024)
Summary: Reactive changes of glial cells during neuroinflammation impact brain disorders and disease progression. Elucidating the mechanisms that control reactive gliosis may help us to understand brain pathophysiology and improve outcomes. Here, we
Externí odkaz:
https://doaj.org/article/85d2608293c54038ac6d9ed11c01f673
Autor:
Sophia Rahimi, Xiaojian Shao, Donovan Chan, Josée Martel, Anick Bérard, William D. Fraser, Marie-Michelle Simon, Tony Kwan, Guillaume Bourque, Jacquetta Trasler
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-21 (2023)
Abstract Background Children conceived through assisted reproduction are at an increased risk for growth and genomic imprinting disorders, often linked to DNA methylation defects. It has been suggested that assisted reproductive technology (ART) and
Externí odkaz:
https://doaj.org/article/e1f7960f8a21419ea087d473363faa22
Autor:
Pierre-Eric Lutz, Marc-Aurèle Chay, Alain Pacis, Gary G. Chen, Zahia Aouabed, Elisabetta Maffioletti, Jean-François Théroux, Jean-Christophe Grenier, Jennie Yang, Maria Aguirre, Carl Ernst, Adriana Redensek, Léon C. van Kempen, Ipek Yalcin, Tony Kwan, Naguib Mechawar, Tomi Pastinen, Gustavo Turecki
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Early-life adversity is thought to increase the risk of psychopathology through epigenetic mechanisms. Here, the authors profile 6 histone marks, chromatin states and DNA methylation in the lateral amygdala in subjects with a history of early-life ad
Externí odkaz:
https://doaj.org/article/8c5757658d8b418787c5d3069801d997
Autor:
Korin Sahinyan, Darren M Blackburn, Marie-Michelle Simon, Felicia Lazure, Tony Kwan, Guillaume Bourque, Vahab D Soleimani
Publikováno v:
eLife, Vol 11 (2022)
Myofibers are the main components of skeletal muscle, which is the largest tissue in the body. Myofibers are highly adaptive and can be altered under different biological and disease conditions. Therefore, transcriptional and epigenetic studies on my
Externí odkaz:
https://doaj.org/article/42fc0b9135ae4f4885d62e564df82426
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-22 (2020)
Abstract Background Epigenomic studies that use next generation sequencing experiments typically rely on the alignment of reads to a reference sequence. However, because of genetic diversity and the diploid nature of the human genome, we hypothesize
Externí odkaz:
https://doaj.org/article/11ec7eaf3dd44399bf0bcc03168ac045
Autor:
Simon Lalonde, Valérie-Anne Codina-Fauteux, Sébastian Méric de Bellefon, Francis Leblanc, Mélissa Beaudoin, Marie-Michelle Simon, Rola Dali, Tony Kwan, Ken Sin Lo, Tomi Pastinen, Guillaume Lettre
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-13 (2019)
Abstract Background Genome-wide association studies (GWAS) have identified hundreds of loci associated with coronary artery disease (CAD) and blood pressure (BP) or hypertension. Many of these loci are not linked to traditional risk factors, nor do t
Externí odkaz:
https://doaj.org/article/413df262aad540eeab4ffe572237954c
Autor:
Fiona Allum, Åsa K. Hedman, Xiaojian Shao, Warren A. Cheung, Jinchu Vijay, Frédéric Guénard, Tony Kwan, Marie-Michelle Simon, Bing Ge, Cristiano Moura, Elodie Boulier, Lars Rönnblom, Sasha Bernatsky, Mark Lathrop, Mark I. McCarthy, Panos Deloukas, André Tchernof, Tomi Pastinen, Marie-Claude Vohl, Elin Grundberg
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Obesity and related metabolic complications represent an important health burden. Here the authors carry out a methylC-capture sequencing-based epigenome-wide association study to link circulating plasma lipid levels, CpG methylation and cardiometabo
Externí odkaz:
https://doaj.org/article/d86745923e464df081cb361accc4f6fc
Autor:
Dirk S. Paul, Andrew E. Teschendorff, Mary A.N. Dang, Robert Lowe, Mohammed I. Hawa, Simone Ecker, Huriya Beyan, Stephanie Cunningham, Alexandra R. Fouts, Anita Ramelius, Frances Burden, Samantha Farrow, Sophia Rowlston, Karola Rehnstrom, Mattia Frontini, Kate Downes, Stephan Busche, Warren A. Cheung, Bing Ge, Marie-Michelle Simon, David Bujold, Tony Kwan, Guillaume Bourque, Avik Datta, Ernesto Lowy, Laura Clarke, Paul Flicek, Emanuele Libertini, Simon Heath, Marta Gut, Ivo G Gut, Willem H. Ouwehand, Tomi Pastinen, Nicole Soranzo, Sabine E. Hofer, Beate Karges, Thomas Meissner, Bernhard O. Boehm, Corrado Cilio, Helena Elding Larsson, Åke Lernmark, Andrea K. Steck, Vardhman K. Rakyan, Stephan Beck, R. David Leslie
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
The incidence of type 1 diabetes is increasing, potentially implicating non-genetic factors. Here the authors conduct an epigenome-wide association study in disease-discordant twins and find increased DNA methylation variability at genes associated w
Externí odkaz:
https://doaj.org/article/74847440186d44ba8513e31e9862b708
Autor:
Jarmo Ritari, Kati Hyvärinen, Satu Koskela, Riitta Niittyvuopio, Anne Nihtinen, Urpu Salmenniemi, Mervi Putkonen, Liisa Volin, Tony Kwan, Tomi Pastinen, Maija Itälä-Remes, Jukka Partanen
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Genetic mismatches in protein coding genes between allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipient and donor can elicit an alloimmunity response via peptides presented by the recipient HLA receptors as minor histocompatibilit
Externí odkaz:
https://doaj.org/article/4caae628e34d40e295dd9ef0ded76eb0
Autor:
Émile Bélanger, Anne-Marie Madore, Anne-Marie Boucher-Lafleur, Marie-Michelle Simon, Tony Kwan, Tomi Pastinen, Catherine Laprise
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 9011 (2020)
(1) Background: The atopic march is defined by the increased prevalence of allergic diseases after atopic dermatitis onset. In fact, atopic dermatitis is believed to play an important role in allergen sensitization via the damaged skin barrier, leadi
Externí odkaz:
https://doaj.org/article/10ad05edf3a64d86a3a1c0fdd6a943f6