Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Tony Kouzarides"'
Autor:
Georgia Tsagkogeorga, Helena Santos-Rosa, Andrej Alendar, Dan Leggate, Oliver Rausch, Tony Kouzarides, Hendrik Weisser, Namshik Han
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
Machine learning of multi-modal data, including transcriptomic, proteomic, structural and physical interaction, predicts genes and molecular pathways involved in RNA methylation in humans.
Externí odkaz:
https://doaj.org/article/396efec7513649209949c08bf1dc3e5d
Autor:
Adrien Leger, Paulo P. Amaral, Luca Pandolfini, Charlotte Capitanchik, Federica Capraro, Valentina Miano, Valentina Migliori, Patrick Toolan-Kerr, Theodora Sideri, Anton J. Enright, Konstantinos Tzelepis, Folkert J. van Werven, Nicholas M. Luscombe, Isaia Barbieri, Jernej Ule, Tomas Fitzgerald, Ewan Birney, Tommaso Leonardi, Tony Kouzarides
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nanopore direct RNA Sequencing data contain information about the presence of RNA modifications, but their detection poses substantial challenges. Here the authors introduce Nanocompore, a new methodology for modification detection from Nanopore data
Externí odkaz:
https://doaj.org/article/b763993df55a44c68f28be519d53614f
Autor:
Samuel Wein, Byron Andrews, Timo Sachsenberg, Helena Santos-Rosa, Oliver Kohlbacher, Tony Kouzarides, Benjamin A. Garcia, Hendrik Weisser
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Mass spectrometry (MS) enables identification of modified RNA residues, but high-throughput processing is currently a bottleneck. Here, the authors present a free and open-source database search engine for RNA MS data to facilitate reliable identific
Externí odkaz:
https://doaj.org/article/3d1187b1870042518abd5163793bbe16
Autor:
Meike Wiese, Andrew J. Bannister, Srinjan Basu, Wayne Boucher, Kai Wohlfahrt, Maria A. Christophorou, Michael L. Nielsen, David Klenerman, Ernest D. Laue, Tony Kouzarides
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-17 (2019)
Abstract Background Stem cell differentiation involves major chromatin reorganisation, heterochromatin formation and genomic relocalisation of structural proteins, including heterochromatin protein 1 gamma (HP1γ). As the principal reader of the repr
Externí odkaz:
https://doaj.org/article/3abeefb38c8647619e3e0901093a5eca
Autor:
Konstantinos Tzelepis, Etienne De Braekeleer, Demetrios Aspris, Isaia Barbieri, M. S. Vijayabaskar, Wen-Hsin Liu, Malgorzata Gozdecka, Emmanouil Metzakopian, Hamish D. Toop, Monika Dudek, Samuel C. Robson, Francisco Hermida-Prado, Yu Hsuen Yang, Roya Babaei-Jadidi, Dimitrios A. Garyfallos, Hannes Ponstingl, Joao M. L. Dias, Paolo Gallipoli, Michael Seiler, Silvia Buonamici, Binje Vick, Andrew J. Bannister, Roland Rad, Rab K. Prinjha, John C. Marioni, Brian Huntly, Jennifer Batson, Jonathan C. Morris, Cristina Pina, Allan Bradley, Irmela Jeremias, David O. Bates, Kosuke Yusa, Tony Kouzarides, George S. Vassiliou
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
SRPK1, a kinase involved in splicing regulation, is a potential therapeutic target for AML patients. Here, the authors show that SRPK1 inhibition changes isoform levels of key epigenetic regulators, including BRD4, and it has anti-tumor effects speci
Externí odkaz:
https://doaj.org/article/1853a1ced0ff46dfaf75bec9896c8581
Autor:
Paulo P. Amaral, Tommaso Leonardi, Namshik Han, Emmanuelle Viré, Dennis K. Gascoigne, Raúl Arias-Carrasco, Magdalena Büscher, Luca Pandolfini, Anda Zhang, Stefano Pluchino, Vinicius Maracaja-Coutinho, Helder I. Nakaya, Martin Hemberg, Ramin Shiekhattar, Anton J. Enright, Tony Kouzarides
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-21 (2018)
Abstract Background The mammalian genome is transcribed into large numbers of long noncoding RNAs (lncRNAs), but the definition of functional lncRNA groups has proven difficult, partly due to their low sequence conservation and lack of identified sha
Externí odkaz:
https://doaj.org/article/ba55c45d1fc5416e815d876c54e498ef
Autor:
Meng Amy Li, Paulo P Amaral, Priscilla Cheung, Jan H Bergmann, Masaki Kinoshita, Tüzer Kalkan, Meryem Ralser, Sam Robson, Ferdinand von Meyenn, Maike Paramor, Fengtang Yang, Caifu Chen, Jennifer Nichols, David L Spector, Tony Kouzarides, Lin He, Austin Smith
Publikováno v:
eLife, Vol 6 (2017)
Execution of pluripotency requires progression from the naïve status represented by mouse embryonic stem cells (ESCs) to a state capacitated for lineage specification. This transition is coordinated at multiple levels. Non-coding RNAs may contribute
Externí odkaz:
https://doaj.org/article/10bac2ec83364a588083e62380429289
Autor:
Mark A. Dawson, Samuel D. Foster, Andrew J. Bannister, Samuel C. Robson, Rebecca Hannah, Xiaonan Wang, Blerta Xhemalce, Andrew D. Wood, Anthony R. Green, Berthold Göttgens, Tony Kouzarides
Publikováno v:
Cell Reports, Vol 2, Iss 3, Pp 470-477 (2012)
The JAK2 tyrosine kinase is a critical mediator of cytokine-induced signaling. It plays a role in the nucleus, where it regulates transcription by phosphorylating histone H3 at tyrosine 41 (H3Y41ph). We used chromatin immunoprecipitation coupled to m
Externí odkaz:
https://doaj.org/article/ab41808cb7824feba4f92a5c2bea78b2
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29765 (2012)
Post-translational modification of histone proteins are known to play an important role in regulating chromatin structure. In an effort to find additional histone modifications we set out to screen enzymes of the 2-oxoglutarate and Fe(II)-dependent (
Externí odkaz:
https://doaj.org/article/609d55d4e46a4a0fbc55f5df72910803
Autor:
Michael Opel, David Lando, Carolina Bonilla, Sarah C Trewick, Abdelhalim Boukaba, Julian Walfridsson, James Cauwood, Petra J H Werler, Antony M Carr, Tony Kouzarides, Natalia V Murzina, Robin C Allshire, Karl Ekwall, Ernest D Laue
Publikováno v:
PLoS ONE, Vol 2, Iss 4, p e386 (2007)
In order to gain a more global view of the activity of histone demethylases, we report here genome-wide studies of the fission yeast SWIRM and polyamine oxidase (PAO) domain homologues of mammalian LSD1. Consistent with previous work we find that the
Externí odkaz:
https://doaj.org/article/cc439e5abb7d4151ada48e31c7e1eea4