Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Tony K L, Kiang"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 743 (2024)
Indoxyl sulfate (IxS) and p-cresyl sulfate (pCS) are toxic uremic compounds with documented pathological outcomes. This review critically and comprehensively analyzes the available liquid chromatography-mass spectrometry methods quantifying IxS and p
Externí odkaz:
https://doaj.org/article/fb877d9953b443f3bf6acce75d55ec2b
Publikováno v:
Drugs in R&D, Vol 20, Iss 4, Pp 343-358 (2020)
Abstract Background and objective Phenytoin is extensively protein bound with a narrow therapeutic range. The unbound phenytoin is pharmacologically active, but total concentrations are routinely measured in clinical practice. The relationship betwee
Externí odkaz:
https://doaj.org/article/39ca7c0df77643c69970309d8cdedeff
Publikováno v:
Pharmaceutics, Vol 13, Iss 6, p 857 (2021)
The toxicological effects of p-cresol have primarily been attributed to its metabolism products; however, very little human data are available in the key organ (i.e., liver) responsible for the generation of these metabolites. Experiments were conduc
Externí odkaz:
https://doaj.org/article/bc5cee06bfdf479c85c2c58de5c5d522
Publikováno v:
British Journal of Clinical Pharmacology. 87:1730-1757
Mycophenolic acid (MPA) is widely used in paediatric kidney transplant patients and sometimes prescribed for additional indications. Population pharmacokinetic or pharmacodynamic modelling has been frequently used to characterize the fixed, random an
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 46:1-24
The objectives of this qualitative review were to critically evaluate and summarize the currently available data on the use of anti-tuberculosis (TB) drugs during pregnancy, with a focus on treatment outcomes, safety, and pharmacokinetics. This quali
Publikováno v:
Clinical drug investigation. 42(3)
Mycophenolic acid (MPA) is a commonly prescribed life-long immunosuppressant for kidney transplant recipients. The frequently observed large variations in MPA plasma exposure may lead to severe adverse outcomes; therefore, characterizations of contri
Autor:
Tony K. L. Kiang, Mary H H Ensom
Publikováno v:
Clinical Pharmacokinetics. 58:1533-1552
Mycophenolic acid is commonly prescribed in adult kidney transplant recipients for preventing graft rejection. A therapeutic target for total mycophenolic acid area under the concentration–time curve (30–60 mg h/L) has been established in adult k
Publikováno v:
Clinical Pharmacokinetics. 58:1483-1495
Mycophenolic acid is commonly prescribed to adult kidney transplant recipients. Mycophenolic acid is extensively metabolized to mycophenolic acid-glucuronide (major metabolite) and mycophenolic acid-acyl-glucuronide (minor metabolite). We hypothesize
Autor:
Yan Rong, Tony K. L. Kiang
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 176(2)
p-Cresol is a uremic toxin that is formed by intestinal microbiota and extensively conjugated by first-pass metabolism. p-Cresol glucuronide exerts various forms of cellular toxicity in vitro and is accumulated in the plasma of subjects with kidney d
Autor:
R Jean Shapiro, Abby C. Collier, Mary H H Ensom, Nilufar Partovi, Tony K. L. Kiang, Jacob M. Berman
Publikováno v:
Clinical Drug Investigation. 38:1011-1022
The hematological side effects associated with mycophenolic acid (MPA) are relatively common and have severe consequences. The majority of literature data have not shown clear consistency in the MPA exposure-neutropenia relationship. We hypothesized