Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Tony J. Zheng"'
Autor:
Iván Parra-Izquierdo, Hari Hara Sudhan Lakshmanan, Alexander R. Melrose, Jiaqing Pang, Tony J. Zheng, Kelley R. Jordan, Stéphanie E. Reitsma, Owen J. T. McCarty, Joseph E. Aslan
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Circulating platelets establish a variety of immunological programs and orchestrate inflammatory responses at the endothelium. Platelets express the innate immunity family of Toll-like receptors (TLRs). While TLR2/TLR1 ligands are known to activate p
Externí odkaz:
https://doaj.org/article/9b44b61965f34b2ea2e72ad2d0c58527
Autor:
Tony J. Zheng, Tia C. L. Kohs, Paul A. Mueller, Jiaqing Pang, Stéphanie E. Reitsma, Iván Parra-Izquierdo, Alexander R. Melrose, Liping Yang, Jaewoo Choi, Keith D. Zientek, Denis O. Sviridov, Mark K. Larson, Craig D. Williams, Nathalie Pamir, Joseph J. Shatzel, Ashok P. Reddy, Paul Kievit, Alan T. Remaley, Jan F. Stevens, Monica T. Hinds, Owen J. T. McCarty, Joseph E. Aslan
Publikováno v:
Blood Advances. 7:1366-1378
Low-density lipoprotein (LDL) contributes to atherogenesis and cardiovascular disease through interactions with peripheral blood cells, especially platelets. However, mechanisms by which LDL affects platelet activation and atherothrombosis, and how t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb9061d7c836954e38769f23cd4424c
https://doi.org/10.1182/bloodadvances.2022007169
https://doi.org/10.1182/bloodadvances.2022007169
Autor:
Tony J. Zheng, Iván Parra-Izquierdo, Stéphanie E. Reitsma, Michael C. Heinrich, Mark K. Larson, Joseph J. Shatzel, Joseph E. Aslan, Owen J. T. McCarty
Publikováno v:
American Journal of Physiology-Cell Physiology. 323:C1231-C1250
Tyrosine kinase inhibitors (TKIs) have emerged as a promising class of target-directed, small molecule inhibitors used to treat hematologic malignancies, inflammatory diseases, and autoimmune disorders. Recently, TKIs have also gained interest as pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d09662577e77e2d89a0459109050391
https://doi.org/10.1152/ajpcell.00040.2022
https://doi.org/10.1152/ajpcell.00040.2022
Assessment of the effects of Syk and BTK inhibitors on GPVI-mediated platelet signaling and function
Autor:
Tony J. Zheng, Elizabeth R Lofurno, Joseph J. Shatzel, Joseph E. Aslan, Alexander R. Melrose, Monica T. Hinds, Tia C L Kohs, Hari Hara Sudhan Lakshmanan, Kevin G. Phillips, Owen J. T. McCarty, Jiaqing Pang, Meghan E. Fallon, Anh T. P. Ngo
Publikováno v:
Am J Physiol Cell Physiol
Spleen tyrosine kinase (Syk) and Bruton’s tyrosine kinase (BTK) play critical roles in platelet physiology, facilitating intracellular immunoreceptor tyrosine-based activation motif (ITAM)-mediated signaling downstream of platelet glycoprotein VI (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab081a5d70d0489d8d10b0bf411dca1d
https://doi.org/10.1152/ajpcell.00296.2020
https://doi.org/10.1152/ajpcell.00296.2020
Autor:
Tony J Zheng, Jiaqing pang, Tia Kohs, Stephanie Reitsma, Iván Parra-Izquierdo, Alexander Melrose, Mark Larson, Craig D Williams, Monica T Hinds, Owen JT McCarty, Joseph E Aslan
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42
Background & Objective: Oxidized low density lipoprotein (oxLDL) contributes to atherogenesis and cardiovascular disease through interactions with peripheral blood cells, especially platelets. However, the mechanisms by which oxLDL affects platelet a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1459e3d70eedb75408667efa9157dfef
https://doi.org/10.1161/atvb.42.suppl_1.159
https://doi.org/10.1161/atvb.42.suppl_1.159
Autor:
Hari Hara Sudhan Lakshmanan, Aldrich Estonilo, Stéphanie E. Reitsma, Alexander R. Melrose, Jayaram Subramanian, Tony J. Zheng, Jeevan Maddala, Erik I. Tucker, David Gailani, Owen J.T. McCarty, Patrick L. Jurney, Cristina Puy
Publikováno v:
J Thromb Haemost
BACKGROUND: Biochemical reaction networks are self-regulated in part due to feedback activation mechanisms. The tissue factor (TF) pathway of blood coagulation is a complex reaction network controlled by multiple feedback loops that coalesce around t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a4d67835534a64318190f99815fe55
https://europepmc.org/articles/PMC9590754/
https://europepmc.org/articles/PMC9590754/
Autor:
Tia C L, Kohs, Sven R, Olson, Jiaqing, Pang, Kelley R, Jordan, Tony J, Zheng, Aris, Xie, James, Hodovan, Matthew, Muller, Carrie, McArthur, Jennifer, Johnson, Bárbara B, Sousa, Michael, Wallisch, Paul, Kievit, Joseph E, Aslan, João D, Seixas, Gonçalo J L, Bernardes, Monica T, Hinds, Jonathan R, Lindner, Owen J T, McCarty, Cristina, Puy, Joseph J, Shatzel
Publikováno v:
Cell Mol Bioeng
INTRODUCTION: Inflammatory activation of the vascular endothelium leads to overexpression of adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1), contributing to the pro-thrombotic state underpinning atherogenesis. While the role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::629673dc47069dbf841dd7a194fa529e
https://pubmed.ncbi.nlm.nih.gov/35611166
https://pubmed.ncbi.nlm.nih.gov/35611166
Autor:
Malinda T. West, Thomas Kartika, Ashley R. Paquin, Erik Liederbauer, Tony J. Zheng, Lucy Lane, Kyaw Thein, Joseph J. Shatzel
Publikováno v:
Curr Probl Cancer
Cyclin dependent kinase 4 of 6 inhibitors (CDKi) are key therapeutics in the treatment of advanced breast cancer and have recently been approved in small cell lung cancer for the prevention of myelosuppression. Thrombotic events have emerged as a sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3624ef11813916c9d1af11689243ff28
https://europepmc.org/articles/PMC9009191/
https://europepmc.org/articles/PMC9009191/
Autor:
Jessica Minnier, Owen J. T. McCarty, Emek Demir, Phillip A. Wilmarth, Samuel Tassi Yunga, Özgün Babur, Jiaqing Pang, Jennifer M. Cunliffe, Anna Liisa I. Sepp, Ashok P. Reddy, Jevgenia Zilberman-Rudenko, Iván Parra-Izquierdo, John Klimek, Alexander R. Melrose, Joseph E. Aslan, Larry L. David, Tony J. Zheng
Publikováno v:
Blood
Platelets engage cues of pending vascular injury through coordinated adhesion, secretion, and aggregation responses. These rapid, progressive changes in platelet form and function are orchestrated downstream of specific receptors on the platelet surf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294ffe926402540c2cd6f90d02b819c9
https://europepmc.org/articles/PMC7702475/
https://europepmc.org/articles/PMC7702475/
Autor:
Owen J. T. McCarty, Joseph J. Shatzel, Alexander R. Melrose, Joseph E. Aslan, Tony J. Zheng, Sarah Elgamal, Jiaqing Pang, Elizabeth R Lofurno
Publikováno v:
Blood. 134:2074-2074
Small molecule tyrosine kinase inhibitors (TKIs) serve increasingly important roles in the treatment of hematologic malignancies and also have shown efficacy in a range of immunological and inflammatory conditions. However, many successful TKI therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f42c57e84de381b2bccca793ec663b33
https://doi.org/10.1182/blood-2019-129066
https://doi.org/10.1182/blood-2019-129066