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Abstract LB058: Performance of a cell-free DNA-based multi-cancer detection test as a tool for diagnostic resolution of symptomatic cancers

Autor: Carlos Becerra, Donald A. Richards, Michael V. Seiden, Jingjing Gao, Earl Hubbell, Quan Zhang, Xiaoji Chen, Minetta C. Liu, Eric T. Fung, Kathryn N. Kurtzman, Nan Zhang, Eric A. Klein, Arash Jamshidi, Alan H. Bryce, Tony J. Wu, David D. Thiel

Publikováno v: Cancer Research. 81:LB058-LB058

Introduction: A test that detects cancer signal across multiple cancer types and predicts signal (tissue) origin (SO) could aid in more efficient diagnostic workup and shorten time to cancer diagnosis in individuals with signs and symptoms.Methods: T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6902a8c84fe75ced1b8574df4c9cb189
https://doi.org/10.1158/1538-7445.am2021-lb058

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Abstract CT021: Prediction of cancer and tissue of origin in individuals with suspicion of cancer using a cell-free DNA multi-cancer early detection test

Autor: Quan Zhang, Eric T. Fung, Earl Hubbell, Xiaoji Chen, Jessica L. Yecies, Geoffrey R. Oxnard, Anne-Renee Hartman, Hai Liu, Tony J. Wu, Alex Aravanis, Kathryn N. Kurtzman, Michael V. Seiden, David D. Thiel, Minetta C. Liu, Nan Zhang, Eric A. Klein

Publikováno v: Cancer Research. 80:CT021-CT021

Background: The Circulating Cell-free Genome Atlas study (NCT02889978) is a multi-center, case-control, observational study with longitudinal follow-up (n=15,254; 56% cancer, 44% non-cancer) to support development of a cell-free DNA (cfDNA) multi-can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::399596f8c7b51c2b704a46288aeb41f8
https://doi.org/10.1158/1538-7445.am2020-ct021

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Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer

Autor: Joseph Marcotrigiano, Barzin Y. Nabet, Tony J. Wu, Joseph L. Benci, Angela DeMichele, Taewon Yoon, Jacob E. Shabason, Yu Qiu, Brian C. Kim, Andy J. Minn, Julia Tchou

Publikováno v: Cell. 170(2)

Interactions between stromal fibroblasts and cancer cells generate signals for cancer progression, therapy resistance, and inflammatory responses. Although endogenous RNAs acting as damage-associated molecular patterns (DAMPs) for pattern recognition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb425c3a43561168dee1049ae1e047a1
https://pubmed.ncbi.nlm.nih.gov/28708994

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Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways

Autor: Barzin Y. Nabet, Taewon Yoon, Diana J. Azzam, Jos Jonkers, Joyce M. Slingerland, Brianne Z. Wiemann, Andy J. Minn, Christina Twyman-Saint Victor, Hemant Ishwaran, Yu Qiu, Petra ter Brugge, Tony J. Wu, Mirjam C. Boelens, Bihui Xu

SummaryStromal communication with cancer cells can influence treatment response. We show that stromal and breast cancer (BrCa) cells utilize paracrine and juxtacrine signaling to drive chemotherapy and radiation resistance. Upon heterotypic interacti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d2293c70e3c5877d068ee8ed900f6f

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Abstract A45: Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways in triple-negative breast cancer

Autor: Andy J. Minn, Barzin Y. Nabet, Tony J. Wu, Bihui Xu, Jos Jonkers, Mirjam C. Boelens

Publikováno v: Cancer Research. 76:A45-A45

Breast cancer cells can achieve protection from DNA damage both through cell-autonomous mechanisms and intercellular communication with the tumor microenvironment. Previously, we described an Interferon-Related DNA Damage Resistance Signature compris

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60584c2283104886e2a73602c4f823f2
https://doi.org/10.1158/1538-7445.tme16-a45

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Abstract 3822: Targeting TPX2 arrested cell cycle progression, raised multinuclearity, ploidy, and suppresses tumorigenicity in hepatocellular carcinoma cells

Autor: Tony J. Wu, Chao-Wen Hsu, Hung-Wei Pan, Yu Chia Chen

Publikováno v: Cancer Research. 76:3822-3822

Background: Hepatocellular carcinoma (HCC) remains one of the most difficult cancers to treat, with chemotherapies being relatively ineffective. Therefore, a better knowledge of molecular hepatocarcinogenesis will provide the opportunity for designed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d70a353a86235f2d3f4d187ede0ade1f
https://doi.org/10.1158/1538-7445.am2016-3822

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Abstract 2751: ASPM, a cell cycle regulated gene and silencing its splicing variant as a molecular target in hepatocellular carcinoma

Autor: Hey-Chi Hsu, Tony J. Wu, Hung-Wei Pan, Su-Yeh Lin

Publikováno v: Cancer Research. 74:2751-2751

ASPM gene is the human orthologue of the Drosophila abnormal spindle (asp). As its drosophila orthologue, ASPM protein associates with centrosomes and involves in organizing MTs at the spindle poles in mitosis and meiosis. Homozygous mutation of Dros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7fdffd0a7c610b69976d1c6855ab0f49
https://doi.org/10.1158/1538-7445.am2014-2751

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Abstract 1505: Stroma-mediated DNA damage resistance of human breast cancer

Autor: Andy J. Minn, Mirjam C. Boelens, Diana J. Azzam, Taewon Yoon, Tony J. Wu, Joyce M. Slingerland

Publikováno v: Cancer Research. 72:1505-1505

Chemotherapy and radiation are often employed to decrease breast cancer deaths. However, patients with metastatic disease invariably manifest resistance to chemotherapy and/or radiation, ultimately causing breast cancer deaths due to ineffective trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe12c2f59d97837613c0f193b09906a4
https://doi.org/10.1158/1538-7445.am2012-1505

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