Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Tony J. Savage"'
Autor:
Robert J. Shaw, Matthew C. Catley, Kerryn McCluskie, Tony J. Savage, Jorge De Alba, Clarissa J. Watts, Robert Newton, Saleem Haj-Yahia, Maria G. Belvisi, K. Tao Pun, Sissie Wong, Mark A. Birrell, Elizabeth Hardaker
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 172:962-971
Rationale Nuclear factor (NF)-kappaB is a transcription factor known to regulate the expression of many inflammatory genes, including cytokines, chemokines, and adhesion molecules. NF-kappaB is held inactive in the cytoplasm, bound to I-kappaB. The r
Publikováno v:
American journal of respiratory cell and molecular biology. 23(2)
Fibrosis in the reticular layer beneath the epithelial basement membrane is a feature of airway remodeling in human asthma. We previously reported the presence of subepithelial fibrosis (SEF) in a disease model of atopic asthma in which mice were sen
Autor:
Tony J. Savage, Helen Bright, Shahin Sanjar, David I. Blyth, Julian E. Beesley, Michael S. Pedrick
Publikováno v:
American journal of respiratory cell and molecular biology. 19(1)
We recently described a murine model of atopic asthma in which a marked, extensive hyperplasia of airway goblet cells is induced by repeated challenge of ovalbumin (OA)-sensitized mice with intratracheally administered allergen (Am. J. Respir. Cell M
Publikováno v:
American journal of respiratory cell and molecular biology. 14(5)
A murine model of allergen-induced airway inflammation and epithelial phenotypic change, and the time-courses of these events, are described. Mice were sensitized to ovalbumin using an adjuvant-free protocol, and challenged by multiple intratracheal