Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Tony J. Savage"'
Autor:
Robert J. Shaw, Matthew C. Catley, Kerryn McCluskie, Tony J. Savage, Jorge De Alba, Clarissa J. Watts, Robert Newton, Saleem Haj-Yahia, Maria G. Belvisi, K. Tao Pun, Sissie Wong, Mark A. Birrell, Elizabeth Hardaker
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 172:962-971
Rationale Nuclear factor (NF)-kappaB is a transcription factor known to regulate the expression of many inflammatory genes, including cytokines, chemokines, and adhesion molecules. NF-kappaB is held inactive in the cytoplasm, bound to I-kappaB. The r
Publikováno v:
American journal of respiratory cell and molecular biology. 23(2)
Fibrosis in the reticular layer beneath the epithelial basement membrane is a feature of airway remodeling in human asthma. We previously reported the presence of subepithelial fibrosis (SEF) in a disease model of atopic asthma in which mice were sen
Autor:
Tony J. Savage, Helen Bright, Shahin Sanjar, David I. Blyth, Julian E. Beesley, Michael S. Pedrick
Publikováno v:
American journal of respiratory cell and molecular biology. 19(1)
We recently described a murine model of atopic asthma in which a marked, extensive hyperplasia of airway goblet cells is induced by repeated challenge of ovalbumin (OA)-sensitized mice with intratracheally administered allergen (Am. J. Respir. Cell M
Publikováno v:
American journal of respiratory cell and molecular biology. 14(5)
A murine model of allergen-induced airway inflammation and epithelial phenotypic change, and the time-courses of these events, are described. Mice were sensitized to ovalbumin using an adjuvant-free protocol, and challenged by multiple intratracheal
Autor:
Chen, Shao-xing, Huang, Feng-ying, Tan, Guang-hong, Wang, Cai-chun, Huang, Yong-hao, Wang, Hua, Zhou, Song-lin, Chen, Fan, Lin, Ying-ying, Liu, Jun-bao
Publikováno v:
Journal of Zhejiang University: Science B; Jan2009, Vol. 10 Issue 1, p22-28, 7p
Iκ-B Kinase-2 Inhibitor Blocks Inflammation in Human Airway Smooth Muscle and a Rat Model of Asthma.
Autor:
Birrell, Mark A., Hardaker, Elizabeth, Wong, Sissie, McCluskie, Kerryn, Catley, Matthew, De Alba, Jorge, Newton, Robert, Haj-Yahia, Saleem, Pun, K. Tao, Watts, Clarissa J., Shaw, Robert J., Savage, Tony J., Belvisi, Maria G.
Publikováno v:
American Journal of Respiratory & Critical Care Medicine; 2005, Vol. 172 Issue 8, p962-971, 23p, 10 Graphs
Publikováno v:
American Journal of Respiratory Cell & Molecular Biology; 2000, Vol. 23 Issue 2, p241-246, 6p, 4 Graphs
Autor:
Karel Petrak, Author
Precision medicine requires precision drugs that match the needs of individual patients. An ideal drug, popularly referred to as the “magic bullet”, should be effective without causing any unwanted side effects. To do this, drugs must act solely