Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Tony J C Harris"'
Autor:
Junior J West, Tony J C Harris
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0239357 (2020)
Cytohesin Arf-GEFs promote actin polymerization and protrusions of cultured cells, whereas the Drosophila cytohesin, Steppke, antagonizes actomyosin networks in several developmental contexts. To reconcile these findings, we analyzed epidermal leadin
Externí odkaz:
https://doaj.org/article/7c9f3fb76a934aceb07d077c8e0a8f34
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142562 (2015)
The recruitment of GDP/GTP exchange factors (GEFs) to specific subcellular sites dictates where they activate small G proteins for the regulation of various cellular processes. Cytohesins are a conserved family of plasma membrane GEFs for Arf small G
Externí odkaz:
https://doaj.org/article/0093012d9c134956bd429f9803d77a94
Autor:
Cao Guo Yu, Raffi Tonikian, Corinna Felsensteiner, Jacquelyn R Jhingree, Darrell Desveaux, Sachdev S Sidhu, Tony J C Harris
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86412 (2014)
The Par complex is a conserved cell polarity regulator. Bazooka/Par-3 is scaffold for the complex and contains three PDZ domains in tandem. PDZ domains can act singly or synergistically to bind the C-termini of interacting proteins. Sequence comparis
Externí odkaz:
https://doaj.org/article/50728456facd4889884e7f13165d5e26
Autor:
Gabrielle Goldenberg, Tony J C Harris
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79613 (2013)
During Drosophila gastrulation, amnioserosa (AS) cells flatten and spread as an epithelial sheet. We used AS morphogenesis as a model to investigate how adherens junctions (AJs) distribute along elongating cell-cell contacts in vivo. As the contacts
Externí odkaz:
https://doaj.org/article/03b5ba7d86a44982974e387afa74989a
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e9938 (2010)
BACKGROUND:The development and homeostasis of multicellular organisms depends on sheets of epithelial cells. Bazooka (Baz; PAR-3) localizes to the apical circumference of epithelial cells and is a key hub in the protein interaction network regulating
Externí odkaz:
https://doaj.org/article/5b70b02c3d0b4e4aafd914077d523a4a
Publikováno v:
Molecular Biology of the Cell. 33
During Drosophila dorsal closure, the SCAR/WAVE complex localizes to adherens junctions of the leading edge actomyosin cable in response to myosin activators and the junctional Arf-GEF Steppke.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6e066e5c934f4c731bd726cb5624d41
https://doi.org/10.1091/mbc.e22-03-0107
https://doi.org/10.1091/mbc.e22-03-0107
Autor:
Tony J. C. Harris, Tao Jiang
Publikováno v:
The Journal of Cell Biology
The cell cortex is populated by various proteins, but it is unclear how they interact to change cell shape. Jiang and Harris find that the kinase Par-1 is required for Diaphanous-based actin bundles, and that these bundles intersperse with separately
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed497cd60cbed6b167bd1a8b5eb6e01
http://europepmc.org/articles/PMC6891076
http://europepmc.org/articles/PMC6891076
Autor:
Milena Pellikka, Norbert Perrimon, Frederik Wirtz-Peitz, Ulrich Tepass, Takashi Nishimura, Dong Yan, Jordan T. Silver, Yan Li, Tony J. C. Harris, Sérgio Simões, Richard Binari
Publikováno v:
The Journal of Cell Biology
Silver et al. show that the RhoGEF Cysts links apical polarity proteins to Rho1 and myosin activation at adherens junctions to support junctional and epithelial integrity in the Drosophila ectoderm.
The spatio-temporal regulation of small Rho GT
The spatio-temporal regulation of small Rho GT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cadb7964b52236a2c5eacca67596d9ca
http://europepmc.org/articles/PMC6781438
http://europepmc.org/articles/PMC6781438
Publikováno v:
Molecular Biology of the Cell
Tissue dynamics require regulated interactions between adherens junctions and cytoskeletal networks. For example, myosin-rich adherens junctions recruit the cytohesin Arf-GEF Steppke, which down-regulates junctional tension and facilitates tissue str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219a32466bdf841586e1204b5667f3b7
http://europepmc.org/articles/PMC6938242
http://europepmc.org/articles/PMC6938242