Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Tony Hui"'
Autor:
Camila P E de Souza, Mirela Andronescu, Tehmina Masud, Farhia Kabeer, Justina Biele, Emma Laks, Daniel Lai, Patricia Ye, Jazmine Brimhall, Beixi Wang, Edmund Su, Tony Hui, Qi Cao, Marcus Wong, Michelle Moksa, Richard A Moore, Martin Hirst, Samuel Aparicio, Sohrab P Shah
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 9, p e1008270 (2020)
We present Epiclomal, a probabilistic clustering method arising from a hierarchical mixture model to simultaneously cluster sparse single-cell DNA methylation data and impute missing values. Using synthetic and published single-cell CpG datasets, we
Externí odkaz:
https://doaj.org/article/95e95387e9fb465bb06950a35a44a9d9
Autor:
Tony Hui, Qi Cao, Joanna Wegrzyn-Woltosz, Kieran O'Neill, Colin A. Hammond, David J.H.F. Knapp, Emma Laks, Michelle Moksa, Samuel Aparicio, Connie J. Eaves, Aly Karsan, Martin Hirst
Publikováno v:
Stem Cell Reports, Vol 11, Iss 2, Pp 578-592 (2018)
Summary: Increasing evidence of functional and transcriptional heterogeneity in phenotypically similar cells examined individually has prompted interest in obtaining parallel methylome data. We describe the development and application of such a proto
Externí odkaz:
https://doaj.org/article/2e0fa26ae7804df3820af3c233fd2998
Autor:
Patrick H. W. Chan, Lisa Lee, Erin Kim, Tony Hui, Nikolay Stoynov, Roy Nassar, Michelle Moksa, Dale M. Cameron, Martin Hirst, Joerg Gsponer, Thibault Mayor
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract The yeast Sup35 protein is a subunit of the translation termination factor, and its conversion to the [PSI +] prion state leads to more translational read-through. Although extensive studies have been done on [PSI +], changes at the proteomi
Externí odkaz:
https://doaj.org/article/a569e4de8af44e818ecb8e5ecd751652
Autor:
Renata L.S. Goncalves, Zeqiu Branden Wang, Karen E. Inouye, Grace Yankun Lee, Xiaorong Fu, Jani Saksi, Clement Rosique, Gunes Parlakgul, Ana Paula Arruda, Sheng Tony Hui, Mar Coll Loperena, Shawn C. Burgess, Isabel Graupera, Gökhan S. Hotamisligil
Publikováno v:
bioRxiv
Mitochondrial reactive oxygen species (mROS) are central to physiology. While excess mROS production has been associated with several disease states, its precise sources, regulation, and mechanism of generationin vivoremain unknown, limiting translat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30c4a300c0787e77c86b802a90f13ab
https://doi.org/10.1101/2023.02.21.528863
https://doi.org/10.1101/2023.02.21.528863
Autor:
Aparna Gopal, Megan Fuller, Yu Deng, Mark Boldin, Jennifer M Grants, Aly Karsan, Joanna Wegrzyn, David J.H.F. Knapp, Connie J. Eaves, T. Roderick Docking, Tony Hui, Jenny Li, Marion Shadbolt, Kieran O'Neill, Jeremy Parker, Martin Hirst
Publikováno v:
Blood
Aging is associated with significant changes in the hematopoietic system, including increased inflammation, impaired hematopoietic stem cell (HSC) function, and increased incidence of myeloid malignancy. Inflammation of aging (“inflammaging”) has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cddc71e360685c630725d42b83c602f
https://doi.org/10.1182/blood.2019003105
https://doi.org/10.1182/blood.2019003105
Autor:
Michelle Moksa, Paul H. Miller, Martin Hirst, Fangwu Wang, Philip A. Beer, Tony Hui, R. Keith Humphries, Connie J. Eaves, Colin A. Hammond, Davide Pellacani, Nima Aghaeepour, Carl L. Hansen, Gabrielle Rabu, Marijn T J van Loenhout, David J.H.F. Knapp
Publikováno v:
Nature Cell Biology. 20:710-720
Elucidation of the identity and diversity of mechanisms that sustain long-term human blood cell production remains an important challenge. Previous studies indicate that, in adult mice, this property is vested in cells identified uniquely by their ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24d98b4edcb2f1a6347db482bea6d95d
https://doi.org/10.1038/s41556-018-0104-5
https://doi.org/10.1038/s41556-018-0104-5
Autor:
Daniel Lai, Camila P. E. de Souza, Michelle Moksa, Edmund Su, Sohrab P. Shah, Tony Hui, Martin Hirst, Qi Cao, Beixi Wang, Patricia Ye, Samuel Aparicio, Emma Laks, Farhia Kabeer, Jazmine Brimhall, Mirela Andronescu, Tehmina Masud, Marcus Wong, Richard A. Moore, Justina Biele
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 16, Iss 9, p e1008270 (2020)
PLoS Computational Biology, Vol 16, Iss 9, p e1008270 (2020)
We present Epiclomal, a probabilistic clustering method arising from a hierarchical mixture model to simultaneously cluster sparse single-cell DNA methylation data and impute missing values. Using synthetic and published single-cell CpG datasets, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702d2ed01e80a85e516760b256db21be
https://doi.org/10.1101/414482
https://doi.org/10.1101/414482
Publikováno v:
Protocol Exchange.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c73df9b3cc79a2a3e0c4e269e5fc3571
https://doi.org/10.1038/protex.2018.068
https://doi.org/10.1038/protex.2018.068
Autor:
Samuel Aparicio, Emma Laks, Qi Cao, Aly Karsan, Colin A. Hammond, Joanna Wegrzyn-Woltosz, Michelle Moksa, Martin Hirst, Connie J. Eaves, David J.H.F. Knapp, Kieran O'Neill, Tony Hui
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 11, Iss 2, Pp 578-592 (2018)
Stem Cell Reports, Vol 11, Iss 2, Pp 578-592 (2018)
Summary Increasing evidence of functional and transcriptional heterogeneity in phenotypically similar cells examined individually has prompted interest in obtaining parallel methylome data. We describe the development and application of such a protoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a064b6319c4848c8e3cd3eaac463e75
https://pubmed.ncbi.nlm.nih.gov/30078558
https://pubmed.ncbi.nlm.nih.gov/30078558
Autor:
David J H F, Knapp, Colin A, Hammond, Tony, Hui, Marijn T J, van Loenhout, Fangwu, Wang, Nima, Aghaeepour, Paul H, Miller, Michelle, Moksa, Gabrielle M, Rabu, Philip A, Beer, Davide, Pellacani, R Keith, Humphries, Carl, Hansen, Martin, Hirst, Connie J, Eaves
Publikováno v:
Nature cell biology. 20(6)
Elucidation of the identity and diversity of mechanisms that sustain long-term human blood cell production remains an important challenge. Previous studies indicate that, in adult mice, this property is vested in cells identified uniquely by their ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e4122729fd8da08162e010eb20d675ef
https://pubmed.ncbi.nlm.nih.gov/29802403
https://pubmed.ncbi.nlm.nih.gov/29802403