257 NOT gate gene circuits expand the range of tumor-associated antigens addressable by CAR-NK and -T cell therapies

Autor: Derrick Lee, Han Deng, Marcus Gainer, Chen-Ting Lee, Assen Roguev, Niran Almudhfar, Mengxi Tian, Alice Lam, Michelle Hung, Andrew Banicki, Lawrence Naitmazi, Yongshuai Li, Russell M Gordley, Timothy K Lu, Nicholas W Frankel, Ippolito I Caradonna, Tony Hua, Gozde Yucel, Brian Garrison, Kanya Rajangam

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Externí odkaz: https://doaj.org/article/a70fca20aa804167a3d93d0e3aaf381d

RelA-Induced Interferon Response Negatively Regulates Proliferation.

Autor: Bose S Kochupurakkal, Zhigang C Wang, Tony Hua, Aedin C Culhane, Scott J Rodig, Koraljka Rajkovic-Molek, Jean-Bernard Lazaro, Andrea L Richardson, Debajit K Biswas, J Dirk Iglehart

Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0140243 (2015)

Both oncogenic and tumor-suppressor activities are attributed to the Nuclear Factor kappa B (NF-kB) pathway. Moreover, NF-kB may positively or negatively regulate proliferation. The molecular determinants of these opposing roles of NF-kB are unclear.

Externí odkaz: https://doaj.org/article/e2c8ac55fb3a48a5adfcf77cafd2d682

221 SENTI-401, an allogeneic logic-gated and multi-armed CAR-NK cell therapy for the treatment of CEA-expressing solid tumors with enhanced selectivity and efficacy

Autor: Alba Gonzalez Junca, Nicholas Frankel, Maelig Morvan, Assen Roguev, Michelle Hung, Russell Gordley, Miguel Palermo, Tyler Santomaso, Pearley Chinta, Aldo Sotelo, Marcus Gainer, Derrick Lee, Tony Hua, Andrew Banicki, Mengxi Tian, Niran Almudhfar, Atahualpa Contreras, Chen-Ting Lee, Timothy Lu

Publikováno v: Regular and Young Investigator Award Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fd3d11e6a5040db8551e4d471f50663
https://doi.org/10.1136/jitc-2022-sitc2022.0221

CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer

Autor: Almudena Bosch, Nayeema Akhtar, Miranda Wang, Yong Zeng, Amina Zoubeidi, Stanley Zhou, Yue Yang, Yijun Tian, Felix Y. Feng, Kathleen E. Houlahan, Shancheng Ren, Sujun Chen, Martin J. Walsh, Hyung Joo Lee, Gong-Hong Wei, Musaddeque Ahmed, Mathieu Lupien, Fraser Soares, Paul C. Boutros, David A. Quigley, Alastair H. Davies, Jing Li, Michael Fraser, Jessica Petricca, Liang Wang, Junjie Tony Hua, Parisa Mazrooei, Peiran Su, Haiyang Guo, Jihan Xia, Ting Wang, Housheng Hansen He

Publikováno v: Nature communications, vol 12, iss 1
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Prostate cancer (PCa) risk-associated SNPs are enriched in noncoding cis-regulatory elements (rCREs), yet their modi operandi and clinical impact remain elusive. Here, we perform CRISPRi screens of 260 rCREs in PCa cell lines. We find that rCREs harb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41bef37ac775a58fcbea61c6a669ef9b
https://doi.org/10.1038/s41467-021-21867-0

Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer

Autor: Tesa M. Severson, Shadrielle Melijah G. Espiritu, Stanley Zhou, James R. Hawley, Alex Murison, Sarina Cameron, Fraser Soares, Giacomo Grillo, Paul C. Boutros, Housheng Hansen He, Hwa Young Yun, Mathieu Lupien, Wilbert Zwart, Mona Teng, Takafumi N. Yamaguchi, Christopher Arlidge, Trevor J. Pugh, Julie Livingstone, Yanyun Zhu, Junjie Tony Hua, Parisa Mazrooei, Seyed Ali Madani Tonekaboni, Musaddeque Ahmed, Theodorus van der Kwast, Ken Kron, Robert G. Bristow, Vincent Huang, Michael Fraser

Publikováno v: Nature communications, vol 11, iss 1
Nature Communications, 11(1):441. Nature Publishing Group
Zhou, S, Hawley, J R, Soares, F, Grillo, G, Teng, M, Madani Tonekaboni, S A, Hua, J T, Kron, K J, Mazrooei, P, Ahmed, M, Arlidge, C, Yun, H Y, Livingstone, J, Huang, V, Yamaguchi, T N, Espiritu, S M G, Zhu, Y, Severson, T M, Murison, A, Cameron, S, Zwart, W, van der Kwast, T, Pugh, T J, Fraser, M, Boutros, P C, Bristow, R G, He, H H & Lupien, M 2020, ' Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer ', Nature Communications, vol. 11, no. 1, pp. 441 . https://doi.org/10.1038/s41467-020-14318-9
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications

Prostate cancer is the second most commonly diagnosed malignancy among men worldwide. Recurrently mutated in primary and metastatic prostate tumors, FOXA1 encodes a pioneer transcription factor involved in disease onset and progression through both a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3b626c7d898073e745f03d5f6019068
https://escholarship.org/uc/item/13k437wt