Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Tony Gutschner"'
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110762- (2024)
Summary: The Hippo signaling pathway is an important regulator of organ growth and differentiation, and its deregulation contributes to the development of cancer. The activity of its downstream targets YAP/TAZ depends on adherens junctions. Plakophil
Externí odkaz:
https://doaj.org/article/af7ca01d2d374ae6a183ba0b27f5eb85
Autor:
Julia Rosemann, Jonas Pyko, Roland Jacob, Jana Macho, Matthias Kappler, Alexander W. Eckert, Monika Haemmerle, Tony Gutschner
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 2, Pp 151400- (2024)
Oral squamous cell carcinoma (OSCC) is the most frequent type of cancer of the head and neck area accounting for approx. 377,000 new cancer cases every year. The epithelial-to-mesenchymal transition (EMT) program plays an important role in OSCC progr
Externí odkaz:
https://doaj.org/article/cac7882ac5894cf388855b35b96cbceb
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/32c8650eb4da44e9853b453be3055b7b
Autor:
Jonas Weiße, Julia Rosemann, Lisa Müller, Matthias Kappler, Alexander W. Eckert, Markus Glaß, Danny Misiak, Stefan Hüttelmaier, Wolfgang G. Ballhausen, Mechthild Hatzfeld, Monika Haemmerle, Tony Gutschner
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/fa3ce391f1f44f98982d03725da51593
Autor:
Jonas Weiße, Julia Rosemann, Lisa Müller, Matthias Kappler, Alexander W. Eckert, Markus Glaß, Danny Misiak, Stefan Hüttelmaier, Wolfgang G. Ballhausen, Mechthild Hatzfeld, Monika Haemmerle, Tony Gutschner
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-23 (2021)
Abstract Background Cancer metastases are the main cause of lethality. The five-year survival rate for patients diagnosed with advanced stage oral cancer is 30%. Hence, the identification of novel therapeutic targets is an urgent need. However, tumor
Externí odkaz:
https://doaj.org/article/2fab5abc84ca4a3daabdfded742fbe0b
Autor:
Tony Gutschner
Publikováno v:
RNA Biology, Vol 0, Iss 0, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/1fdc2e07c2fb45529a56775c2c6cc4d0
Publikováno v:
Non-Coding RNA, Vol 7, Iss 4, p 67 (2021)
The cohesin complex is a multi-subunit protein complex initially discovered for its role in sister chromatid cohesion. However, cohesin also has several other functions and plays important roles in transcriptional regulation, DNA double strand break
Externí odkaz:
https://doaj.org/article/ed2a30e77cd244358dbbc391ca1e595a
Autor:
Monika Haemmerle, Morgan L. Taylor, Tony Gutschner, Sunila Pradeep, Min Soon Cho, Jianting Sheng, Yasmin M. Lyons, Archana S. Nagaraja, Robert L. Dood, Yunfei Wen, Lingegowda S. Mangala, Jean M. Hansen, Rajesha Rupaimoole, Kshipra M. Gharpure, Cristian Rodriguez-Aguayo, Sun Young Yim, Ju-Seog Lee, Cristina Ivan, Wei Hu, Gabriel Lopez-Berestein, Stephen T. Wong, Beth Y. Karlan, Douglas A. Levine, Jinsong Liu, Vahid Afshar-Kharghan, Anil K. Sood
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Platelets have been associated with increased tumor growth and metastasis but the mechanistic details of this interaction are still unclear. Here the authors show that platelets improve anoikis resistance of cancer cells and increase metastasis by ac
Externí odkaz:
https://doaj.org/article/efca299554474b9dba711b2ea7a0c35f
Publikováno v:
Cell Reports, Vol 14, Iss 6, Pp 1555-1566 (2016)
CRISPR/Cas9 induces DNA double-strand breaks that are repaired by cell-autonomous repair pathways, namely, non-homologous end-joining (NHEJ), or homology-directed repair (HDR). While HDR is absent in G1, NHEJ is active throughout the cell cycle and,
Externí odkaz:
https://doaj.org/article/c9082a5c5b7f4918990c4d489a495469
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 20, p 7614 (2020)
Platelets are highly abundant cell fragments of the peripheral blood that originate from megakaryocytes. Beside their well-known role in wound healing and hemostasis, they are emerging mediators of the immune response and implicated in a variety of p
Externí odkaz:
https://doaj.org/article/0b3b23c24c4643428a450558eb46d6ce