Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Tony E. Walshe"'
Autor:
Valur Emilsson, Elias F. Gudmundsson, Thorarinn Jonmundsson, Brynjolfur G. Jonsson, Michael Twarog, Valborg Gudmundsdottir, Zhiguang Li, Nancy Finkel, Stephen Poor, Xin Liu, Robert Esterberg, Yiyun Zhang, Sandra Jose, Chia-Ling Huang, Sha-Mei Liao, Joseph Loureiro, Qin Zhang, Cynthia L. Grosskreutz, Andrew A. Nguyen, Qian Huang, Barrett Leehy, Rebecca Pitts, Thor Aspelund, John R. Lamb, Fridbert Jonasson, Lenore J. Launer, Mary Frances Cotch, Lori L. Jennings, Vilmundur Gudnason, Tony E. Walshe
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Age related macular degeneration is a common cause of visual impairment in the elderly, but the etiology is not fully understood. Here, the authors use genetic data, serum proteomics, and AMD phenotypic data from a large Icelandic cohort to discover
Externí odkaz:
https://doaj.org/article/74ea238d5b954380bfe2f61fbea0fa44
Autor:
Tony E Walshe, Magali Saint-Geniez, Arindel S R Maharaj, Eiichi Sekiyama, Angel E Maldonado, Patricia A D'Amore
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5149 (2009)
Pericyte-endothelial cell (EC) interactions are critical to both vascular development and vessel stability. We have previously shown that TGF-beta signaling between EC and mural cells participates in vessel stabilization in vitro. We therefore invest
Externí odkaz:
https://doaj.org/article/e349d0a04e0b48aa8b3950c7983ccb0b
Autor:
Magali Saint-Geniez, Arindel S R Maharaj, Tony E Walshe, Budd A Tucker, Eiichi Sekiyama, Tomoki Kurihara, Diane C Darland, Michael J Young, Patricia A D'Amore
Publikováno v:
PLoS ONE, Vol 3, Iss 11, p e3554 (2008)
Vascular endothelial growth factor (VEGF) is well known for its role in normal and pathologic neovascularization. However, a growing body of evidence indicates that VEGF also acts on non-vascular cells, both developmentally as well as in the adult. I
Externí odkaz:
https://doaj.org/article/bead3d11b19c41c68a74e8e7a509f97c
Autor:
Rangaprasad Sarangarajan, Christos Chinopoulos, Kenjiro Kami, Niven R. Narain, Luke J. Taus, Michael A. Kiebish, Roberto Flores, Laura M. Shelton, Ashley K. Brown, Julianna Khoury, Thomas N. Seyfried, Frank Glover, Tony E. Walshe
Publikováno v:
Biochimica et biophysica acta. Bioenergetics. 1859(9)
Succinate is known to act as an inflammatory signal in classically activated macrophages through stabilization of HIF-1α leading to IL-1β production. Relevant to this, hypoxia is known to drive succinate accumulation and release into the extracellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d86f502ffa24ef5c22aa97273f1d90a
https://pubmed.ncbi.nlm.nih.gov/29580805
https://pubmed.ncbi.nlm.nih.gov/29580805
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 33:2608-2617
Objective— Vascular endothelial cells (ECs) are continuously exposed to blood flow that contributes to the maintenance of vessel structure and function; however, the effect of hemodynamic forces on transforming growth factor-β (TGF-β) signaling i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::639407eadb3b75b32f58685fad9b86bf
https://doi.org/10.1161/atvbaha.113.302161
https://doi.org/10.1161/atvbaha.113.302161
Vascular endothelial growth factor is important for brown adipose tissue development and maintenance
Autor:
Mandrita Bagchi, Tony E. Walshe, Jeremie Boucher, C. Ronald Kahn, Patricia A. D'Amore, Leo A. Kim
Publikováno v:
The FASEB Journal. 27:3257-3271
Vascular endothelial growth factor (VEGF) is critical for angiogenesis, but also has pleiotropic effects on several nonvascular cells. Our aim was to investigate the role of VEGF in brown adipose tissue (BAT). We show that VEGF expression increases 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50fe2de825d59e3d6c624f61e9e4df6
https://doi.org/10.1096/fj.12-221812
https://doi.org/10.1096/fj.12-221812
Publikováno v:
Neuroscience. 189:123-131
Purpose. To determine the role of TGF-β1 in the maintenance of retinal ganglion cell line (RGC-5) differentiation and integrity. Methods. RGC-5 cells were differentiated in media conditioned by human non-pigmented ciliary epithelial cells (HNPE) for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca88fb3459114c29b76ea677211a500
https://doi.org/10.1016/j.neuroscience.2011.05.020
https://doi.org/10.1016/j.neuroscience.2011.05.020
Publikováno v:
Cardiovascular Research. 89:661-670
Aims Aberrant retinal blood flow is a hallmark of various retinopathies and may be a causative factor in the pathology associated with these conditions. We examined the effects of pulsatile flow on bovine retinal endothelial cell (BREC) and bovine re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c092dd05df4d13dce9d862863f18782
https://doi.org/10.1093/cvr/cvq341
https://doi.org/10.1093/cvr/cvq341
Autor:
Tony E. Walshe
Publikováno v:
Microvascular Research. 80:166-173
Aberrant transforming growth factor-beta (TGF-beta) signaling plays a clear role in a number of pathologies, in particular, fibrotic diseases and cancer. Accumulating evidence also suggests that TGF-beta is required for vascular homeostasis, shedding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64cf4273424171eeecb91b278df0ade6
https://doi.org/10.1016/j.mvr.2010.03.003
https://doi.org/10.1016/j.mvr.2010.03.003
Autor:
Colm O'Brien, Eileen M. Redmond, Tony E. Walshe, Dermot Walls, Paul A. Cahill, Shaunta Guha, Yvonne A. Birney, Catherine Sweeney, David A. Morrow
Publikováno v:
Circulation Research. 103:1370-1382
The Notch signaling pathway is critical for cell fate determination during embryonic development, including many aspects of vascular development. An emerging paradigm suggests that the Notch gene regulatory network is often recapitulated in the conte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317a3e5b2f84b8da81c5d3a06a274e33
https://doi.org/10.1161/circresaha.108.187534
https://doi.org/10.1161/circresaha.108.187534