Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Tony D. Davis"'
Autor:
Jeffrey T. Mindrebo, Ashay Patel, Woojoo E. Kim, Tony D. Davis, Aochiu Chen, Thomas G. Bartholow, James J. La Clair, J. Andrew McCammon, Joseph P. Noel, Michael D. Burkart
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The formation of C-C bonds in fatty acid and polyketide biosynthesis depends on β-ketoacyl-acyl carrier protein (ACP) synthases (KSs). Here, the authors present structures of E.coli KSs bound to substrate mimetic bearing ACPs, providing insights int
Externí odkaz:
https://doaj.org/article/8b2f324577e8467b8bb69a969b0ffd83
Autor:
Joshua C. Corpuz, Ashay Patel, Tony D. Davis, Larissa M. Podust, J. Andrew McCammon, Michael D. Burkart
Publikováno v:
ACS chemical biology. 17(10)
Non-ribosomal peptides play a critical role in the clinic as therapeutic agents. To access more chemically diverse therapeutics, non-ribosomal peptide synthetases (NRPSs) have been targeted for engineering through combinatorial biosynthesis; however,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ceaf2e85991be0f54674ffee913483d
https://pubmed.ncbi.nlm.nih.gov/36173802
https://pubmed.ncbi.nlm.nih.gov/36173802
Publikováno v:
Journal of Phycology. 57:754-765
Using Nile Red and BODIPY 493/503 dye-staining and fluorescence microscopy, twenty cyanobacterial strains, including ten commercially available strains and ten environmental isolates from estuaries, freshwater ponds, and lagoons, were screened for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f8e2d2ef63288759ea52a8972d950d
https://doi.org/10.1111/jpy.13123
https://doi.org/10.1111/jpy.13123
Autor:
Ruben Abagyan, Tony D. Davis, Michael D. Burkart, Thomas G. Bartholow, Megan A Young, Terra Sztain
Publikováno v:
RSC Chemical Biology
Lipoic acid is an essential cofactor produced in all organisms by diverting octanoic acid derived as an intermediate of type II fatty acid biosynthesis. In bacteria, octanoic acid is transferred from the acyl carrier protein (ACP) to the lipoylated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49107a54a7b84f634f2c3e01cc6e89b
https://doi.org/10.1039/d1cb00125f
https://doi.org/10.1039/d1cb00125f
Autor:
Aochiu Chen, Jeffrey T. Mindrebo, Tony D. Davis, Woojoo E. Kim, Yohei Katsuyama, Ziran Jiang, Yasuo Ohnishi, Joseph P. Noel, Michael D. Burkart
Publikováno v:
Acta crystallographica. Section D, Structural biology. 78(Pt 9)
Ketosynthases (KSs) catalyse essential carbon–carbon bond-forming reactions in fatty-acid biosynthesis using a two-step, ping-pong reaction mechanism. In Escherichia coli, there are two homodimeric elongating KSs, FabB and FabF, which possess overl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ddac663ab6c89e806b5195c14705f5
https://pubmed.ncbi.nlm.nih.gov/36048156
https://pubmed.ncbi.nlm.nih.gov/36048156
Autor:
Aochiu Chen, Jeffrey T. Mindrebo, Tony D. Davis, Woojoo E. Kim, Yohei Katsuyama, Ziran Jiang, Yasuo Ohnishi, Joseph P. Noel, Michael D. Burkart
Ketosynthases (KS) catalyse essential carbon-carbon bond forming reactions in fatty acid biosynthesis using a two-step, ping-pong reaction mechanism. In E. coli, there are two homodimeric elongating KSs, FabB and FabF, both of which possess overlappi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22b6f1dac41ec51eb2215919587db698
https://doi.org/10.1101/2022.04.04.486996
https://doi.org/10.1101/2022.04.04.486996
Autor:
Thomas G. Bartholow, Terra Sztain, Megan A. Young, D. John Lee, Tony D. Davis, Ruben Abagyan, Michael D. Burkart
Publikováno v:
Biochemistry
Biochemistry, vol 61, iss 7
Biochemistry, vol 61, iss 7
Carrier protein-dependent biosynthesis provides a thiotemplated format for the production of natural products. Within these pathways, many reactions display exquisite substrate selectivity, a regulatory framework proposed to be controlled by protein-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eff102f2ba1ba80ed5693f7b1e11c49
https://europepmc.org/articles/PMC9769579/
https://europepmc.org/articles/PMC9769579/
Autor:
Joseph P. Noel, Ashay Patel, J. Andrew McCammon, Tony D. Davis, Jeffrey T. Mindrebo, Michael D. Burkart, Laëtitia Misson
Publikováno v:
Proceedings of the National Academy of Sciences. 117:24224-24233
Fatty acid synthases (FASs) and polyketide synthases (PKSs) iteratively elongate and often reduce two-carbon ketide units in de novo fatty acid and polyketide biosynthesis. Cycles of chain extensions in FAS and PKS are initiated by an acyltransferase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cae7f23aab9bcb82fca006391868f6ff
https://doi.org/10.1073/pnas.2009805117
https://doi.org/10.1073/pnas.2009805117
Publikováno v:
Nat Prod Rep
Covering: 1990 to 2019 Many medicinally-relevant compounds are derived from non-ribosomal peptide synthetase (NRPS) products. Type I NRPSs are organized into large modular complexes, while type II NRPS systems contain standalone or minimal domains th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f6740c99fd03fcda1a0c7b289fd7c1
https://doi.org/10.1039/c9np00047j
https://doi.org/10.1039/c9np00047j
Autor:
D. John Lee, Michael D. Burkart, Ashay Patel, Terra Sztain, J. Andrew McCammon, Tony D. Davis
Publikováno v:
Angew Chem Int Ed Engl
Angewandte Chemie (International ed. in English), vol 58, iss 32
Angewandte Chemie, vol 131, iss 32
Angewandte Chemie (International ed. in English), vol 58, iss 32
Angewandte Chemie, vol 131, iss 32
At the center of many complex biosynthetic pathways, the acyl carrier protein (ACP) shuttles substrates to appropriate enzymatic partners to produce fatty acids and polyketides. Carrier proteins covalently tether their cargo via a thioester linkage t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739cb464b989cc380b804439d283724e
https://doi.org/10.1002/anie.201903815
https://doi.org/10.1002/anie.201903815