Synaptic Effects of Munc18-1 Alternative Splicing in Excitatory Hippocampal Neurons.

Autor: Marieke Meijer, Tony Cijsouw, Ruud F Toonen, Matthijs Verhage

Publikováno v: PLoS ONE, Vol 10, Iss 9, p e0138950 (2015)

The munc18-1 gene encodes two splice-variants that vary at the C-terminus of the protein and are expressed at different levels in different regions of the adult mammalian brain. Here, we investigated the expression pattern of these splice variants wi

Externí odkaz: https://doaj.org/article/5c5beee94bc6467ea4039d8365ead389

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse

Autor: Alexandros K. Kanellopoulos, Neale Bm, Harold D. MacGillavry, Mahdokht Kohansal-Nodehi, Natasha K. Hussain, Rebecca E. Foulger, Vincent O'Connor, Ruud F. Toonen, Ghazaleh Ashrafi, Camila Pulido, Cordelia Imig, Arthur P.H. de Jong, Michael R. Kreutz, L. Niels Cornelisse, Timothy A. Ryan, Tilmann Achsel, Guoping Feng, Morgan Sheng, John Jia En Chua, Eckart D. Gundelfinger, Paul Thomas, David Osumi-Sutherland, Noa Lipstein, Haiming Tang, Danielle Posthuma, Hagen Tilgner, Chiara Verpelli, Nimra Asi, Kyoko Watanabe, Pietro De Camilli, Hana L. Goldschmidt, Jaime de Juan-Sanz, Rita Reig-Viader, Momchil Ninov, Barbara Kramarz, Àlex Bayés, Peter S. McPherson, Pim van Nierop, Hwajin Jung, Tony Cijsouw, Huaiyu Mi, Pascal S. Kaeser, Thomas C. Südhof, Marcelo P. Coba, Eunjoon Kim, Richard L. Huganir, Robert C. Malenka, Marc Feuermann, Daniel P. Howrigan, Roger A. Nicoll, Nils Brose, Pascale Gaudet, Daniela C. Dieterich, Andrea Byrnes, Carlo Sala, Anoushka Joglekar, Jan R.T. van Weering, Claudia Bagni, Frank Koopmans, Casper C. Hoogenraad, Matthijs Verhage, Katherine Tashman, Ryan J. Farrell, Vittoria Mariano, Rainer Pielot, Thomas Biederer, Reinhard Jahn, August B. Smit, Ruth C. Lovering, Karl-Heinz Smalla, Maria Andres-Alonso, Steven E. Hyman, Tyler C. Brown

Publikováno v: Neuron, 103(2), 217. Cell Press
Neuron
Koopmans, F, van Nierop, P, Andres-Alonso, M, Byrnes, A, Cijsouw, T, Coba, M P, Cornelisse, L N, Farrell, R J, Goldschmidt, H L, Howrigan, D P, Hussain, N K, Imig, C, de Jong, A P H, Jung, H, Kohansalnodehi, M, Kramarz, B, Lipstein, N, Lovering, R C, MacGillavry, H, Mariano, V, Mi, H, Ninov, M, Osumi-Sutherland, D, Pielot, R, Smalla, K-H, Tang, H, Tashman, K, Toonen, R F G, Verpelli, C, Reig-Viader, R, Watanabe, K, van Weering, J, Achsel, T, Ashrafi, G, Asi, N, Brown, T C, de Camilli, P, Feuermann, M, Foulger, R E, Gaudet, P, Joglekar, A, Kanellopoulos, A, Malenka, R, Nicoll, R A, Pulido, C, de Juan-Sanz, J, Sheng, M, Südhof, T C, Tilgner, H U, Bagni, C, Bayés, À, Biederer, T, Brose, N, Chua, J J E, Dieterich, D C, Gundelfinger, E D, Hoogenraad, C, Huganir, R L, Jahn, R, Kaeser, P S, Kim, E, Kreutz, M R, McPherson, P S, Neale, B M, O'Connor, V, Posthuma, D, Ryan, T A, Sala, C, Feng, G, Hyman, S E, Thomas, P D, Smit, A B & Verhage, M 2019, ' SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse ', Neuron, vol. 103, no. 2, pp. 217-234.e4 . https://doi.org/10.1016/j.neuron.2019.05.002
Koopmans, F, van Nierop, P, Andres-Alonso, M, Byrnes, A, Cijsouw, T, Coba, M P, Cornelisse, L N, Farrell, R J, Goldschmidt, H L, Howrigan, D P, Hussain, N K, Imig, C, de Jong, A P H, Jung, H, Kohansalnodehi, M, Kramarz, B, Lipstein, N, Lovering, R C, MacGillavry, H, Mariano, V, Mi, H, Ninov, M, Osumi-Sutherland, D, Pielot, R, Smalla, K H, Tang, H, Tashman, K, Toonen, R F G, Verpelli, C, Reig-Viader, R, Watanabe, K, van Weering, J, Achsel, T, Ashrafi, G, Asi, N, Brown, T C, De Camilli, P, Feuermann, M, Foulger, R E, Gaudet, P, Joglekar, A, Kanellopoulos, A, Malenka, R, Nicoll, R A, Pulido, C, de Juan-Sanz, J, Sheng, M, Südhof, T C, Tilgner, H U, Bagni, C, Bayés, À, Biederer, T, Brose, N, Chua, J J E, Dieterich, D C, Gundelfinger, E D, Hoogenraad, C, Huganir, R L, Jahn, R, Kaeser, P S, Kim, E, Kreutz, M R, McPherson, P S, Neale, B M, O'Connor, V, Posthuma, D, Ryan, T A, Sala, C, Feng, G, Hyman, S E, Thomas, P D, Smit, A B & Verhage, M 2019, ' SynGO : An Evidence-Based, Expert-Curated Knowledge Base for the Synapse ', Neuron, vol. 103, no. 2, pp. 217-234.e4 . https://doi.org/10.1016/j.neuron.2019.05.002
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r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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Neuron, 103(2), 217-234.e4. Cell Press

© 2019 Elsevier Inc. Synapses are fundamental information-processing units of the brain, and synaptic dysregulation is central to many brain disorders (“synaptopathies”). However, systematic annotation of synaptic genes and ontology of synaptic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9363c39520e59a7e5697474577ba275
https://dspace.library.uu.nl/handle/1874/384389

Munc18-1 redistributes in nerve terminals in an activity- and PKC-dependent manner

Autor: Jurjen H. Broeke, Ruud F. Toonen, Ingrid Saarloos, Matthijs Verhage, Jens P. Weber, Tim Kroon, Tony Cijsouw, Desiree Schut, Jantine A.C. Broek

Publikováno v: The Journal of Cell Biology; Vol 204
The Journal of Cell Biology

PKC-dependent dynamic control of Munc18-1 levels enables individual synapses to tune their output during periods of activity.
Munc18-1 is a soluble protein essential for synaptic transmission. To investigate the dynamics of endogenous Munc18-1 i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d5115dd8ed87e1a5d4d19ba51a0ae4

Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity

Autor: Michael R. Hayden, Roshni R. Singaraja, Alaa El-Husseini, Shaun S. Sanders, Pamela Arstikaitis, Anat Yanai, Kun Huang, Tony Cijsouw, Paul C. Orban

Publikováno v: The FASEB Journal. 23:2605-2615

Palmitoylation, a post-translational modification of cysteine residues with the lipid palmitate, has recently emerged as an important mechanism for regulating protein trafficking and function. With the identification of 23 DHHC mammalian palmitoyl ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1c7e3797eede2cee6b33a313490c78
https://doi.org/10.1096/fj.08-127399

Chromatin mobility is increased at sites of DNA double-strand breaks

Autor: Jan Stap, Przemek M. Krawczyk, Nicolaas A. P. Franken, Jacob A. Aten, Tijana Borovski, Tony Cijsouw, Roland Kanaar, Jan Paul Medema, R. ten Cate

Publikováno v: Journal of cell science, 125(9), 2127-2133. Company of Biologists Ltd
Journal of Cell Science, 125(9), 2127-2133. Company of Biologists Ltd

DNA double-strand breaks (DSBs) can efficiently kill cancer cells, but they can also produce unwanted chromosome rearrangements when DNA ends from different DSBs are erroneously joined. Movement of DSB-containing chromatin domains might facilitate th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f2e6f45aa39a1ac4c12916d7e200756
https://doi.org/10.1242/jcs.089847