Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Tony Christopeit"'
Autor:
Florian Wanke, Simon Gutbier, Anna Rümmelin, Malte Steinberg, Lindsey D. Hughes, Mascha Koenen, Juliana Komuczki, Daniel Regan-Komito, Sagie Wagage, Julia Hesselmann, Ralf Thoma, Doris Brugger, Tony Christopeit, Hayian Wang, Floriane Point, Remy Hallet, Sourav Ghosh, Carla V. Rothlin, Christoph Patsch, Barbara Geering
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-13 (2021)
Abstract Removal of apoptotic cells by phagocytes (also called efferocytosis) is a crucial process for tissue homeostasis. Professional phagocytes express a plethora of surface receptors enabling them to sense and engulf apoptotic cells, thus avoidin
Externí odkaz:
https://doaj.org/article/01cf059ac626494a908897f862c90ad3
Autor:
Marianne S Jensen, Lasse Fredriksen, Alasdair K MacKenzie, Phillip B Pope, Ingar Leiros, Piotr Chylenski, Adele K Williamson, Tony Christopeit, Heidi Østby, Gustav Vaaje-Kolstad, Vincent G H Eijsink
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197862 (2018)
Enzymatic depolymerization of recalcitrant polysaccharides plays a key role in accessing the renewable energy stored within lignocellulosic biomass, and natural biodiversities may be explored to discover microbial enzymes that have evolved to conquer
Externí odkaz:
https://doaj.org/article/ed21b464c7d24b65acdcb0a185455089
Publikováno v:
Marine Drugs, Vol 11, Iss 11, Pp 4279-4293 (2013)
The screening of extracts from marine organisms is a widely used strategy to discover new drug leads. A common problem in the screening process is the generation of false positive hits through unspecific effects from the complex chemical composition
Externí odkaz:
https://doaj.org/article/d29205b896b34901b6f23ab1c976bcfc
Autor:
Jan Eckmann, Tanja Fauti, Aintzane Zabaleta, Laura Blanco, Sahar Kassem, Nadege Carrié, Stefan Lorenz, Alejandro Carpy, Tony Christopeit, Georg Fertig, Luise Bernasconi, Marlene Biehl, Sarah Diggelmann, Melanie Knobloch, Maud Mayoux, Charles Dumontet, Bruno Paiva, Ludovic Martinet, Stéphane Leclair, Wei Xu, Christian Klein, Pablo Umaña
Publikováno v:
Blood. 140:2091-2092
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0b708bcef465860aaa94df761933da6
https://doi.org/10.1182/blood-2022-157485
https://doi.org/10.1182/blood-2022-157485
Autor:
Alexander Knaupp, Christoph Gstöttner, Manfred Wuhrer, Dietmar Reusch, Elena Domínguez-Vega, Tony Christopeit, Michaela Hook, Markus Haberger, Tilman Schlothauer
Publikováno v:
Analytical Chemistry
Analytical Chemistry, 93(45), 15133-15141. AMER CHEMICAL SOC
Analytical Chemistry, 93(45), 15133-15141. AMER CHEMICAL SOC
Monoclonal antibody (mAb) pharmaceuticals consist of a plethora of different proteoforms with different functional characteristics, including pharmacokinetics and pharmacodynamics, requiring their individual assessment. Current binding techniques do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cebbff5f0106af654b0a04c742dc105
https://zenodo.org/record/6777244
https://zenodo.org/record/6777244
Autor:
Anna Rümmelin, Malte Steinberg, Ralf Thoma, Simon Gutbier, Florian Wanke, Floriane Point, Hayian Wang, Barbara Geering, Sagie Wagage, Carla V. Rothlin, Doris Brugger, Christoph Patsch, Remy Hallet, Lindsey D. Hughes, Daniel Regan-Komito, Julia Hesselmann, Tony Christopeit, Sourav Ghosh, Mascha Koenen, Juliana Komuczki
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Removal of apoptotic cells by phagocytes (also called efferocytosis) is a crucial process for tissue homeostasis. Professional phagocytes express a plethora of surface receptors enabling them to sense and engulf apoptotic cells, thus avoiding persist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec23ca5716b1a1ac6ad80c51c959ccc6
https://doi.org/10.1038/s41419-021-03770-0
https://doi.org/10.1038/s41419-021-03770-0
Autor:
Hanna-Kirsti S. Leiros, Susann Skagseth, Marc Boomgaren, Zeeshan Muhammad, Annette Bayer, Christopher Fröhlich, Tony Christopeit, Sundus Akhter, Aya Ismael
Publikováno v:
'Bioorganic & Medicinal Chemistry ', vol: 28, pages: 115598-1-115598-11 (2020)
Metallo-β-lactamases (MBLs) are an emerging cause of bacterial antibiotic resistance by hydrolysing all classes of β-lactams except monobactams, and the MBLs are not inhibited by clinically available serine-β-lactamase inhibitors. Two of the most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c9123c3cb9f1506443baac33af3e20
https://hdl.handle.net/10037/18778
https://hdl.handle.net/10037/18778
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:2947-2953
The inhibition of metallo-β-lactamases (MBL) can prevent the hydrolysis of β-lactam antibiotics and hence is a promising strategy for the treatment of antibiotic resistant infections. In this study, we present a novel reversible covalent inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600339a0dbd58d4355c6a09bda000213
https://doi.org/10.1016/j.bmc.2016.04.064
https://doi.org/10.1016/j.bmc.2016.04.064
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1973-1977
Metallo-β-lactamases (MBLs) render bacteria resistant to β-lactam antibiotics and are interesting drug targets to prevent the hydrolysis of β-lactam antibiotics. So far, there are no MBL inhibitors in clinical use and particularly the design of br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca2e4be8255ada35b343d30f6fe27f2
https://doi.org/10.1016/j.bmcl.2016.03.004
https://doi.org/10.1016/j.bmcl.2016.03.004
Autor:
Birgit Helene Berg Nesheim, Ane Molden Thomassen, Tony Christopeit, Hanna-Kirsti S. Leiros, Johan Isaksson, Bjarte Aarmo Lund, Trine Josefine Olsen Carlsen
Publikováno v:
The FEBS journal. 285(22)
Many class D β-lactamases form dimers in solution. The functional basis of the dimerization of OXA-48-like class D β-lactamases is not known, but in order to understand the structural requirements for dimerization of OXA-48, we have characterized t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ffae060a50b135df4f59a05f213b8c
https://pubmed.ncbi.nlm.nih.gov/30153368
https://pubmed.ncbi.nlm.nih.gov/30153368