Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Tony Cano"'
Autor:
Anthony R. Haight, Tony Cano, Brittney J. Mills, Vikram Sisodiya, Feroz Jameel, Ehab M. Moussa
Publikováno v:
Development of Biopharmaceutical Drug-Device Products ISBN: 9783030314149
Antibody-drug conjugates (ADCs) have emerged as a new class of anti-cancer drugs where the strengths of cytotoxic small molecules are combined with specificity/selectivity of antibodies to enhance the therapeutic efficacy and safety of the drug. All
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bd2d164ae8f701c19cc3450f80c8eb2
https://doi.org/10.1007/978-3-030-31415-6_2
https://doi.org/10.1007/978-3-030-31415-6_2
Publikováno v:
Journal of Chromatography A. 1144:197-202
Competitive adsorption isotherms for two conservative surface charge-neutralizing mutants of cytochrome b5, E11Q and E44Q, previously measured with competitor concentration held constant over the range of the isotherm, were used to test three widely-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3703993f6ef5a139e0076acd2e8a04
https://doi.org/10.1016/j.chroma.2007.01.059
https://doi.org/10.1016/j.chroma.2007.01.059
Publikováno v:
Biotechnology Progress. 22:519-522
Mechanical lysis is an efficient and widely used method of liberating the contents of microbial cells, but the sensitivity of large nucleic acids to shear damage has prevented the application of mechanical lysis to DNA purification. It is demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a99dd8aea16d82e71a58a85f5a2369
https://doi.org/10.1021/bp050422i
https://doi.org/10.1021/bp050422i
Publikováno v:
Journal of Chromatography A. 1079:116-126
The competitive adsorption processes inevitably present in chromatographic separations of complex mixtures have not been extensively studied. This is partly due to the difficulty of measuring true competitive isotherms, in which all system parameters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb9882cfdca3a290c68d7a7aad649c5
https://doi.org/10.1016/j.chroma.2005.03.120
https://doi.org/10.1016/j.chroma.2005.03.120
Publikováno v:
Journal of chromatography. A. 1218(31)
In this report, we have demonstrated the isolation and enrichment of charge variants of a monoclonal antibody IgG1 using cation exchange displacement chromatography. We successfully achieved the separation of acidic, main and basic charge variants wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c98122fdce262911594a80dfbbaab151
https://pubmed.ncbi.nlm.nih.gov/21700290
https://pubmed.ncbi.nlm.nih.gov/21700290
Autor:
Paul Motchnik, Cynthia P. Quan, Yung-Hsiang Kao, Sirj Goswami, Ihsan Nijem, Reed J. Harris, Ryan Hutchinson, Xiangdan Wang, Tony Cano, Pin Yee Wong, Leslie A. Khawli, Zhenling Yao, Alavattam Sreedhara, Amita Joshi, Devin Tesar, Zephania W. Kwong, David E. Allison, Jihong Yang
Publikováno v:
mAbs. 2(6)
Antibody charge variants have gained considerable attention in the biotechnology industry due to their potential influence on stability and biological activity. Subtle differences in the relative proportions of charge variants are often observed duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d526532a75f03671636e5f1bd9dc1aa5
https://pubmed.ncbi.nlm.nih.gov/20818176
https://pubmed.ncbi.nlm.nih.gov/20818176
Autor:
Daniel Strauss, Tony Cano, Daniel Coleman, Qi Chen, Gregory S. Blank, Nick Cai, Magdalena Plancarte, Bin Yang, Heather Delucchi
Publikováno v:
Biotechnology progress. 26(3)
The quality-by-design (QbD) regulatory initiative promotes the development of process design spaces describing the multidimensional effects and interactions of process variables on critical quality attributes of therapeutic products. However, because
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc46b16bf79444164f22f5d1b1137d0
https://pubmed.ncbi.nlm.nih.gov/20306523
https://pubmed.ncbi.nlm.nih.gov/20306523
Publikováno v:
Biotechnology progress. 21(5)
In contrast to proteins, many nucleic acids can undergo reversible modification of their conformations, and this flexibility can be used to facilitate purification. Selective renaturation with capture is a novel method of removing contaminating genom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165e623da3da2400c03230fad36eb90b
https://pubmed.ncbi.nlm.nih.gov/16209553
https://pubmed.ncbi.nlm.nih.gov/16209553