Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Tony Azzam"'
Publikováno v:
Journal of the American Chemical Society. 131:10557-10566
A vesicle system is described that possesses a pH-induced "breathing" feature and consists of a three-layered wall structure. The "breathing" feature consists of a highly reversible vesicle volume change by a factor of ca. 7, accompanied by diffusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e25fe946757cd10f97299254c10662e2
https://doi.org/10.1021/ja902869q
https://doi.org/10.1021/ja902869q
Publikováno v:
Biomaterials. 30:3597-3604
Here we investigate the potential of PCL-b-PEO micelles in preventing the cell death of isolated human islets of Langerhans. PCL-b-PEO micelles were loaded with c-Jun NH2-terminal kinases inhibitor SP600125 to rescue the isolated islets. Mechanistic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6449f72d7b94030ff65fd64a631717
https://doi.org/10.1016/j.biomaterials.2009.03.028
https://doi.org/10.1016/j.biomaterials.2009.03.028
Autor:
Hagit Eliyahu, Abraham J. Domb, J.P. Schillemans, Yechezkel Barenholz, Tony Azzam, Aviva Joseph
Publikováno v:
Biomaterials. 28:2339-2349
In this study, we compared two systems which can be applied for transfection in vitro and in vivo: polyplexes based on the polymer dextran-spermine (D-SPM) and lipoplexes based on 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP)/cholesterol. The carr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5bb571b68eeea76bc77d1628f5f241b
https://doi.org/10.1016/j.biomaterials.2006.09.001
https://doi.org/10.1016/j.biomaterials.2006.09.001
Publikováno v:
Langmuir. 23:2224-2230
The self-assembly of the biamphiphilic triblock copolymer poly(ethylene oxide)-b-poly(caprolactone)-b-poly(acrylic acid) into polymer vesicles is studied. The vesicles provide both biocompatibility and biodegradability. Moreover, the biamphiphilic na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74fa8393aefc2bd2b7a245b45a033d6e
https://doi.org/10.1021/la062805b
https://doi.org/10.1021/la062805b
Autor:
Tony Azzam, Adi Eisenberg
Publikováno v:
Langmuir. 23:2126-2132
A study is presented of the preparation of gold nanoparticles incorporated into biodegradable micelles. Poly(ethylene oxide)-b-poly(epsilon-caprolactone) (PEO-b-PCL) copolymer was synthesized by ring-opening polymerization, and the hydroxyl end group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ea167b6c7f71679eb458946f65fe445
https://doi.org/10.1021/la0627563
https://doi.org/10.1021/la0627563
Publikováno v:
Biomaterials. 27:1646-1655
Biodegradable water-soluble polysaccharide-spermine (SPM) polycation conjugates for nucleic acid delivery were synthesized by oxidizing polysaccharides using potassium periodate, followed by SPM conjugation. The polycations differ in their polysaccha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a087b54411057613f32bef8f6d21bb4
https://doi.org/10.1016/j.biomaterials.2005.09.005
https://doi.org/10.1016/j.biomaterials.2005.09.005
Publikováno v:
Journal of Medicinal Chemistry. 48:1414-1420
Cationic polysaccharides were synthesized by conjugation of various oligoamines to oxidized polysaccharides by reductive amination and tested for antiprion activity. Polycations of dextran, pullulan and arabinogalactan grafted with oligoamines of 2 t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f0955d1eb6645c3af90069b1e9704d
https://doi.org/10.1021/jm049378o
https://doi.org/10.1021/jm049378o
Autor:
Aviva Joseph, A. Makovitzki, Tony Azzam, Abraham J. Domb, Dan Gazit, Hagit Eliyahu, A Zlotkin, Yechezkel Barenholz
Publikováno v:
Gene Therapy. 12:494-503
Recently, a novel cationic polymer, dextran-spermine (D-SPM) was developed for gene delivery. An efficient transfection was obtained using this polycation for a variety of genes and cell lines in serum-free or serum-poor medium. However, transfection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd0d5aed4351c60eb19fb234fc77324e
https://doi.org/10.1038/sj.gt.3302395
https://doi.org/10.1038/sj.gt.3302395
Publikováno v:
Journal of Controlled Release. 96:309-323
Dextran polysaccharide was grafted by reductive-amination with mixtures of spermine and other natural/synthetic oligoamines of two to four amine groups. The transfection efficiencies of the polycations thus obtained were assessed in various cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518158a1cf3967a6c52501763ae4f168
https://doi.org/10.1016/j.jconrel.2004.01.022
https://doi.org/10.1016/j.jconrel.2004.01.022
Autor:
Abraham J. Domb, Tony Azzam
Publikováno v:
Current Drug Delivery. 1:165-193
DNA can be delivered into the cell nucleus either using physical means or specific carriers that carry the genes into the cells for gene expression). Various carriers for delivering genes have been investigated which can be divided into two main grou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e8d18e82ee5f75d5babe49b666bf53
https://doi.org/10.2174/1567201043479902
https://doi.org/10.2174/1567201043479902