Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Tony A. Navas"'
Autor:
Leonidas C. Platanias, Josh Hayman, Satyanarayana Medicherla, Linda S. Higgins, Jing Ying Ma, Bhaskar Das, Andrea Pellagatti, Perry Pahanish, Krishna Gundabolu, Markus Bitzer, Ying Zhang, Tony A. Navas, Davendra Sohal, Aaron N. Nguyen, Amittha Wickrema, Alan F. List, Suman Kambhampati, Adam Chubak, Tushar D. Bhagat, Simrit Parmar, Ira Braunchweig, Amit Verma, Li Zhou, Jacqueline Boultwood, Yongkai Mo, Ann M. Kapoun
Publikováno v:
Blood. 112:3434-3443
MDS is characterized by ineffective hematopoiesis that leads to peripheral cytopenias. Development of effective treatments has been impeded by limited insight into pathogenic pathways governing dysplastic growth of hematopoietic progenitors. We demon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9e6b227c8bd1b45cd01fc960e45434
https://doi.org/10.1182/blood-2008-02-139824
https://doi.org/10.1182/blood-2008-02-139824
Autor:
Amit Verma, Li Zhou, Tony A. Navas, Simrit Parmar, Perry Pahanish, Linda S. Higgins, Jing Ying Ma, Yin Xu, Myka Estes, Lubomir Sokol, Aaron N. Nguyen, A. List, Leonidas C. Platanias, Mani Mohindru, Edwin Haghnazari, Irene Kerr, Robert H. Collins
Publikováno v:
Blood. 108:4170-4177
The myelodysplastic syndromes (MDSs) are collections of heterogeneous hematologic diseases characterized by refractory cytopenias as a result of ineffective hematopoiesis. Development of effective treatments has been impeded by limited insights into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6089cf63c197a2ad721ebe99a9f52e97
https://doi.org/10.1182/blood-2006-05-023093
https://doi.org/10.1182/blood-2006-05-023093
p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells
Autor:
Yu-Tzu Tai, Dharminder Chauhan, Noopur Raje, Teru Hideshima, Paul G. Richardson, Klaus Podar, Kenji Ishitsuka, Nikhil C. Munshi, Mitsiades Constantine S, Kenneth C. Anderson, Makoto Hamasaki, Linda S. Higgins, Hiromasa Hideshima, Tony A. Navas, George Schreiner, Aaron N. Nguyen
Publikováno v:
Oncogene. 23:8766-8776
PS-341 (pyrazylcarbonyl-Phe-Leu-boronate, bortezomib, Velcade™) represents a class of peptide boronate proteasome inhibitors which inhibit 26S proteasome activity, and demonstrated promise as potential novel anti-cancer therapies. PS-341: induces h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31138c2d3c231802f3ed78c7c4af1ae
https://doi.org/10.1038/sj.onc.1208118
https://doi.org/10.1038/sj.onc.1208118
Publikováno v:
The Journal of Immunology. 167:1882-1885
Flagellin, the structural component of bacterial flagella, is secreted by pathogenic and commensal bacteria. Flagellin activates proinflammatory gene expression in intestinal epithelia. However, only flagellin that contacts basolateral epithelial sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3896d6c1b34a7ac8d3c8a7bd764520db
https://doi.org/10.4049/jimmunol.167.4.1882
https://doi.org/10.4049/jimmunol.167.4.1882
Autor:
Daryl T. Baldwin, Xiaoqing Sun, Tony A. Navas, Timothy A. Stewart, Vishva M. Dixit, James Lee
Publikováno v:
Journal of Biological Chemistry. 274:16871-16875
RIP3 is a novel gene product containing a N-terminal kinase domain that shares extensive homology with the corresponding domain in RIP (receptor-interacting protein) and RIP2. Unlike RIP, which has a C-terminal death domain, and RIP2, which has a C-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d600082f1b07c2817133749b0f59fa68
https://doi.org/10.1074/jbc.274.24.16871
https://doi.org/10.1074/jbc.274.24.16871
Publikováno v:
Genes & Development. 10:2632-2643
In response to DNA damage and replication blocks, yeast cells arrest at distinct points in the cell cycle and induce the transcription of genes whose products facilitate DNA repair. Examination of the inducibility of RNR3 in response to UV damage has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db39d75b80a3c5b7d8c4f5daaa6525c
https://doi.org/10.1101/gad.10.20.2632
https://doi.org/10.1101/gad.10.20.2632
Publikováno v:
BioEssays. 15:333-339
Ribonucleotide reductase (RNR) catalyzes the rate limiting step in the production of deoxyribonucleotides needed for DNA synthesis. In addition to the well documented allosteric regulation, the synthesis of the enzyme is also tightly regulated at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::899cc939652ac4bb2ab06e46662ebfb6
https://doi.org/10.1002/bies.950150507
https://doi.org/10.1002/bies.950150507
Autor:
Satyanarayana, Medicherla, Mamatha, Reddy, Jing, Ying, Tony A, Navas, Lingyun, Li, Aaron N, Nguyen, Irene, Kerr, Nirupama, Hanjarappa, Andrew A, Protter, Linda S, Higgins
Publikováno v:
Anticancer research. 28(6A)
Multiple myeloma (MM) is a clonal plasma cell malignancy, which is currently incurable. Therefore, new mono- or combined therapy treatment regimens in the early and advanced phases of MM are urgently needed to combat this disease. Recently, p38 mitog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1adacd8618c227561ed34b53cd221c74
https://pubmed.ncbi.nlm.nih.gov/19189670
https://pubmed.ncbi.nlm.nih.gov/19189670
Autor:
Babu J. Mavunkel, George F. Schreiner, Ruban Mangadu, John J. Perumattam, Jing Ying Ma, Sundeep Dugar, Andrew A. Protter, Satyanarayana Medicherla, Mamatha M. Reddy, Irene Kerr, Yu Wang Liu, Fabiola Movius, Tony A. Navas, Gregory R. Luedtke, Bruce Koppelman, Ramona Almirez
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 318(1)
Mitogen-activated protein kinases (MAPKs) and heat shock proteins (HSPs) are ubiquitous proteins that function within T cells in both normal and stress-related pathophysiological states, including type 1 diabetes. The nonobese diabetic (NOD) mouse sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3f067d5eb3f7c50c1a30dba6eec2b8
https://pubmed.ncbi.nlm.nih.gov/16603672
https://pubmed.ncbi.nlm.nih.gov/16603672
Autor:
Andy Protter, Sun J. Choi, Jing Y. Ma, Satyanarayana Medicherla, George F. Schreiner, Edwin Haghnazari, Linda S. Higgins, Tony A. Navas, G. David Roodman, Ann M. Kapoun, Mamatha Reddy, Diana Quon, Margaret Henson, Noriyoshi Kurihara, Gilbert O'Young, Debby Damm, Aaron N. Nguyen, Elizabeth G. Stebbins, Judy Anderson
Publikováno v:
Experimental cell research. 312(10)
The multiple myeloma (MM) bone marrow (BM) microenvironment plays a critical role in supporting tumor growth and survival as well as in promoting formation of osteolytic lesions. Recent results suggest that the p38 mitogen-activated protein kinase (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c6126186e2af00f827e412f7766edf
https://pubmed.ncbi.nlm.nih.gov/16600214
https://pubmed.ncbi.nlm.nih.gov/16600214