Zobrazeno 1 - 10
of 825
pro vyhledávání: '"Tony, Wyss-Coray"'
Autor:
Lihua Wang, Niko-Petteri Nykänen, Daniel Western, Priyanka Gorijala, Jigyasha Timsina, Fuhai Li, Zhaohua Wang, Muhammad Ali, Chengran Yang, Menghan Liu, William Brock, Marta Marquié, Mercè Boada, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, Agustín Ruiz, Raquel Puerta, Adelina Orellana, Jarod Rutledge, Hamilton Oh, Michael D Greicius, Yann Le Guen, Richard J. Perrin, Tony Wyss-Coray, Angela Jefferson, Timothy J. Hohman, Neill Graff-Radford, Hiroshi Mori, Alison Goate, Johannes Levin, Yun Ju Sung, Carlos Cruchaga
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-25 (2024)
Abstract Triggering receptor expressed on myeloid cells 2 (TREM2) plays a critical role in microglial activation, survival, and apoptosis, as well as in Alzheimer’s disease (AD) pathogenesis. We previously reported the MS4A locus as a key modulator
Externí odkaz:
https://doaj.org/article/7186895a6614490394229c23126dc1de
Autor:
Fabian Kern, Thomas Kuhn, Nicole Ludwig, Martin Simon, Laura Gröger, Natalie Fabis, Ernesto Aparicio-Puerta, Abdulrahman Salhab, Tobias Fehlmann, Oliver Hahn, Annika Engel, Viktoria Wagner, Marcus Koch, Katarzyna Winek, Hermona Soreq, Irina Nazarenko, Gregor Fuhrmann, Tony Wyss-Coray, Eckart Meese, Verena Keller, Matthias W. Laschke, Andreas Keller
Publikováno v:
RNA Biology, Vol 20, Iss 1, Pp 482-494 (2023)
Previous work on murine models and humans demonstrated global as well as tissue-specific molecular ageing trajectories of RNAs. Extracellular vesicles (EVs) are membrane vesicles mediating the horizontal transfer of genetic information between differ
Externí odkaz:
https://doaj.org/article/c4f989c3cc3d47828f08997c492f2092
Autor:
Zihuai He, Linxi Liu, Michael E. Belloy, Yann Le Guen, Aaron Sossin, Xiaoxia Liu, Xinran Qi, Shiyang Ma, Prashnna K. Gyawali, Tony Wyss-Coray, Hua Tang, Chiara Sabatti, Emmanuel Candès, Michael D. Greicius, Iuliana Ionita-Laza
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The authors present GhostKnockoff, a method for genome-wide association studies which can be applied to enhance existing and future studies to identify functional variants with weaker statistical effects that might be missed by conventional associati
Externí odkaz:
https://doaj.org/article/8a4affe73e044277a90ea1ba3e8812dc
Autor:
Edward N. Wilson, Christina B. Young, Javier Ramos Benitez, Michelle S. Swarovski, Igor Feinstein, Manu Vandijck, Yann Le Guen, Nandita M. Kasireddy, Marian Shahid, Nicole K. Corso, Qian Wang, Gabriel Kennedy, Alexandra N. Trelle, Betty Lind, Divya Channappa, Malia Belnap, Veronica Ramirez, Irina Skylar-Scott, Kyan Younes, Maya V. Yutsis, Nathalie Le Bastard, Joseph F. Quinn, Christopher H. van Dyck, Angus Nairn, Carolyn A. Fredericks, Lu Tian, Geoffrey A. Kerchner, Thomas J. Montine, Sharon J. Sha, Guido Davidzon, Victor W. Henderson, Frank M. Longo, Michael D. Greicius, Anthony D. Wagner, Tony Wyss-Coray, Kathleen L. Poston, Elizabeth C. Mormino, Katrin I. Andreasson
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-12 (2022)
Abstract Background The recent promise of disease-modifying therapies for Alzheimer’s disease (AD) has reinforced the need for accurate biomarkers for early disease detection, diagnosis and treatment monitoring. Advances in the development of novel
Externí odkaz:
https://doaj.org/article/a7c72b7b806e4d5f9c4b0862e6246e4f
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-10 (2022)
Abstract The technological revolution to measure global gene expression at the single-cell level is currently transforming our knowledge of the brain and neurological diseases, leading from a basic understanding of genetic regulators and risk factors
Externí odkaz:
https://doaj.org/article/127236268bd9403fb85795a950ce121c
Autor:
Andrew McKay, Emma K Costa, Jingxun Chen, Chi-Kuo Hu, Xiaoshan Chen, Claire N Bedbrook, Rishad C Khondker, Mike Thielvoldt, Param Priya Singh, Tony Wyss-Coray, Anne Brunet
Publikováno v:
eLife, Vol 11 (2022)
The African turquoise killifish is an exciting new vertebrate model for aging studies. A significant challenge for any model organism is the control over its diet in space and time. To address this challenge, we created an automated and networked fis
Externí odkaz:
https://doaj.org/article/21efc0fc55a84b2998c5672deb075de3
Autor:
Jian Luo, Andy Nguyen, Saul Villeda, Hui Zhang, Zhaoqing Ding, Derek Lindsey, Gregor Bieri, Joseph M. Castellano, Gary S. Beaupre, Tony Wyss-Coray
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/97158b1bcc924446be010917fd1f86a5
Autor:
Hamilton Oh, Olivia Leventhal, Divya Channappa, Victor W. Henderson, Tony Wyss-Coray, Benoit Lehallier, David Gate
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-11 (2021)
Abstract Background Cerebrospinal fluid (CSF) provides basic mechanical and immunological protection to the brain. Historically, analysis of CSF has focused on protein changes, yet recent studies have shed light on cellular alterations. Evidence now
Externí odkaz:
https://doaj.org/article/bbab4b636c0349cbab71e9dfa8bcee31
Autor:
Tobias Fehlmann, Benoit Lehallier, Nicholas Schaum, Oliver Hahn, Mustafa Kahraman, Yongping Li, Nadja Grammes, Lars Geffers, Christina Backes, Rudi Balling, Fabian Kern, Rejko Krüger, Frank Lammert, Nicole Ludwig, Benjamin Meder, Bastian Fromm, Walter Maetzler, Daniela Berg, Kathrin Brockmann, Christian Deuschle, Anna-Katharina von Thaler, Gerhard W. Eschweiler, Sofiya Milman, Nir Barziliai, Matthias Reichert, Tony Wyss-Coray, Eckart Meese, Andreas Keller
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Aging is a key risk factor for chronic diseases of the elderly. Here the authors perform large-scale miRNA profiling of blood from individuals of a range of ages and show that common diseases alter the physiological age-related blood microRNA profile
Externí odkaz:
https://doaj.org/article/132c3d783c2f4f77b4984be2f3b3481b
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-19 (2018)
Abstract Background Neuronal cell loss contributes to the pathology of acute and chronic neurodegenerative diseases, including Alzheimer’s disease (AD). It remains crucial to identify molecular mechanisms sensitizing neurons to various insults and
Externí odkaz:
https://doaj.org/article/1455bbda538b467fae26095a8c256cf7