Výsledky vyhledávání - "Tonke K Raaijmakers"

Akademický článek

NSAIDs affect dendritic cell cytokine production.

Autor: Tonke K Raaijmakers, Renske J E van den Bijgaart, Gert Jan Scheffer, Marleen Ansems, Gosse J Adema

Publikováno v: PLoS ONE, Vol 17, Iss 10, p e0275906 (2022)

BackgroundImmunotherapy is now considered as the new pillar in treatment of cancer patients. Dendritic cells (DCs) play an essential role in stimulating anti-tumor immune responses, as they are capable of cross-presenting exogenous tumor antigens in

Externí odkaz: https://doaj.org/article/9dee8e739d504854ac38fedc250bd4e0

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Akademický článek

Tumor ablation plus co-administration of CpG and saponin adjuvants affects IL-1 production and multifunctional T cell numbers in tumor draining lymph nodes

Autor: Stefan Nierkens, Tonke K Raaijmakers, Renske J E van den Bijgaart, Martijn H den Brok, Melissa Wassink, Annemarie de Graaf, Jori A Wagenaars, Marleen Ansems, Gert Jan Scheffer, Gosse J Adema

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)

Background Tumor ablation techniques, like cryoablation, are successfully used in the clinic to treat tumors. The tumor debris remaining in situ after ablation is a major antigen depot, including neoantigens, which are presented by dendritic cells (D

Externí odkaz: https://doaj.org/article/1d10133bed404d1486826c6a9612772a

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Movie 6 from Metabolic Screening of Cytotoxic T-cell Effector Function Reveals the Role of CRAC Channels in Regulating Lethal Hit Delivery

Autor: Peter Friedl, Bettina Weigelin, Carl G. Figdor, Jeroen A. van der Laak, Tonke K. Raaijmakers, Louis Wolf, Esther Wagena, Cindy E. Dieteren, Jeroen Slaats

Human CTL engagement with an αCD3-coated surface in the absence (DMSO) or presence of BTP2. Morgenstemning LUT, Fura-2 340/380 ratio. Time stamp, min:sec (0 min denoting the time-point of contact initiation). Scale bar, 10 µm.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a305cf1203d3fd4b8c951c89443f688
https://doi.org/10.1158/2326-6066.22544283

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Movie 1 from Metabolic Screening of Cytotoxic T-cell Effector Function Reveals the Role of CRAC Channels in Regulating Lethal Hit Delivery

Autor: Peter Friedl, Bettina Weigelin, Carl G. Figdor, Jeroen A. van der Laak, Tonke K. Raaijmakers, Louis Wolf, Esther Wagena, Cindy E. Dieteren, Jeroen Slaats

OT-I CTL engagement with H2B-GFP-labeled MEC1/OVA cells followed by target cell death. The migration tracks and position of individual CTLs (numbers) are highlighted. Arrowheads highlight different phases of target cell death, including membrane bleb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36bcbd87e2ccf9df92aad233ccefd66e
https://doi.org/10.1158/2326-6066.22544304

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Data from Metabolic Screening of Cytotoxic T-cell Effector Function Reveals the Role of CRAC Channels in Regulating Lethal Hit Delivery

Autor: Peter Friedl, Bettina Weigelin, Carl G. Figdor, Jeroen A. van der Laak, Tonke K. Raaijmakers, Louis Wolf, Esther Wagena, Cindy E. Dieteren, Jeroen Slaats

Cytotoxic T lymphocytes (CTL) mediate cytotoxicity toward tumor cells by multistep cell–cell interactions. However, the tumor microenvironment can metabolically perturb local CTL effector function. CTL activity is typically studied in two-dimension

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7bd87e7ac65a6e963fa33742d719f7
https://doi.org/10.1158/2326-6066.c.6550599.v1

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Movie 3 from Metabolic Screening of Cytotoxic T-cell Effector Function Reveals the Role of CRAC Channels in Regulating Lethal Hit Delivery

Autor: Peter Friedl, Bettina Weigelin, Carl G. Figdor, Jeroen A. van der Laak, Tonke K. Raaijmakers, Louis Wolf, Esther Wagena, Cindy E. Dieteren, Jeroen Slaats

OT-I CTL conjugation with B16F10/OVA cells in the absence (left) or presence (right) of 100 µM H2O2. Morgenstemning LUT, Fura-2 340/380-ratio. Time stamp, min:sec (0 min denoting the timepoint of contact initiation). Scale bar, 10 µm.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::181e5b94c4ed2898a9fa5d100533deeb
https://doi.org/10.1158/2326-6066.22544295.v1

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Movie 2 from Metabolic Screening of Cytotoxic T-cell Effector Function Reveals the Role of CRAC Channels in Regulating Lethal Hit Delivery

Autor: Peter Friedl, Bettina Weigelin, Carl G. Figdor, Jeroen A. van der Laak, Tonke K. Raaijmakers, Louis Wolf, Esther Wagena, Cindy E. Dieteren, Jeroen Slaats

OT-I CTLs engaging with and detaching from B16F10/OVA cells in 2D matrix-free or 3D interface co-culture. Note the frequent instable interactions in 2D matrix-free co-culture but not in 3D interface culture. Time stamp, h:min:sec. Scale bar, 10 µm.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a40e7a52505461efd34e3904641a73
https://doi.org/10.1158/2326-6066.22544298.v1

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Movie 7 from Metabolic Screening of Cytotoxic T-cell Effector Function Reveals the Role of CRAC Channels in Regulating Lethal Hit Delivery

Autor: Peter Friedl, Bettina Weigelin, Carl G. Figdor, Jeroen A. van der Laak, Tonke K. Raaijmakers, Louis Wolf, Esther Wagena, Cindy E. Dieteren, Jeroen Slaats

Single CTL-associated MEC1/OVA Ca2+ event followed by target cell death in control culture (DMSO) and lack of CTL-associated MEC1/OVA Ca2+ events despite stable CTL-target cell interactions in the presence of BTP2. Arrowhead highlights the CTL-associ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006dfcc92b9e53ddd9144c1f08ab8d03
https://doi.org/10.1158/2326-6066.22544277.v1

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