Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Tonke K Raaijmakers"'
Autor:
Renske J. E. van den Bijgaart, Vera E. Mekers, Fabian Schuurmans, Tonke K. Raaijmakers, Melissa Wassink, Andor Veltien, Erik Dumont, Arend Heerschap, Jurgen J. Fütterer, Gosse J. Adema
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionIn situ tumor ablation releases a unique repertoire of antigens from a heterogeneous population of tumor cells. High-intensity focused ultrasound (HIFU) is a completely noninvasive ablation therapy that can be used to ablate tumors either
Externí odkaz:
https://doaj.org/article/43a17c9ddbdb4061898a346b131c9865
Autor:
Tonke K. Raaijmakers, Renske J. E. van den Bijgaart, Gert Jan Scheffer, Marleen Ansems, Gosse J. Adema
Publikováno v:
PLoS ONE, Vol 17, Iss 10 (2022)
Background Immunotherapy is now considered as the new pillar in treatment of cancer patients. Dendritic cells (DCs) play an essential role in stimulating anti-tumor immune responses, as they are capable of cross-presenting exogenous tumor antigens in
Externí odkaz:
https://doaj.org/article/3dcde85997d6466b991b59d9b7fbe3b9
Autor:
Stefan Nierkens, Tonke K Raaijmakers, Renske J E van den Bijgaart, Martijn H den Brok, Melissa Wassink, Annemarie de Graaf, Jori A Wagenaars, Marleen Ansems, Gert Jan Scheffer, Gosse J Adema
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Background Tumor ablation techniques, like cryoablation, are successfully used in the clinic to treat tumors. The tumor debris remaining in situ after ablation is a major antigen depot, including neoantigens, which are presented by dendritic cells (D
Externí odkaz:
https://doaj.org/article/1d10133bed404d1486826c6a9612772a
Autor:
Peter Friedl, Bettina Weigelin, Carl G. Figdor, Jeroen A. van der Laak, Tonke K. Raaijmakers, Louis Wolf, Esther Wagena, Cindy E. Dieteren, Jeroen Slaats
Human CTL engagement with an αCD3-coated surface in the absence (DMSO) or presence of BTP2. Morgenstemning LUT, Fura-2 340/380 ratio. Time stamp, min:sec (0 min denoting the time-point of contact initiation). Scale bar, 10 µm.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a305cf1203d3fd4b8c951c89443f688
https://doi.org/10.1158/2326-6066.22544283
https://doi.org/10.1158/2326-6066.22544283
Autor:
Peter Friedl, Bettina Weigelin, Carl G. Figdor, Jeroen A. van der Laak, Tonke K. Raaijmakers, Louis Wolf, Esther Wagena, Cindy E. Dieteren, Jeroen Slaats
OT-I CTL engaging with a MEC1/OVA target cell followed by target cell rounding and cell death in the absence (DMSO) or presence of BTP2. Time stamp, h:min. Scale bar, 10 µm.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e02f2685ddded44dbdd94aea5a3b023
https://doi.org/10.1158/2326-6066.22544289
https://doi.org/10.1158/2326-6066.22544289
Autor:
Peter Friedl, Bettina Weigelin, Carl G. Figdor, Jeroen A. van der Laak, Tonke K. Raaijmakers, Louis Wolf, Esther Wagena, Cindy E. Dieteren, Jeroen Slaats
OT-I CTL engagement with H2B-GFP-labeled MEC1/OVA cells followed by target cell death. The migration tracks and position of individual CTLs (numbers) are highlighted. Arrowheads highlight different phases of target cell death, including membrane bleb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36bcbd87e2ccf9df92aad233ccefd66e
https://doi.org/10.1158/2326-6066.22544304
https://doi.org/10.1158/2326-6066.22544304
Autor:
Peter Friedl, Bettina Weigelin, Carl G. Figdor, Jeroen A. van der Laak, Tonke K. Raaijmakers, Louis Wolf, Esther Wagena, Cindy E. Dieteren, Jeroen Slaats
OT-I CTL conjugation with MEC1/OVA cells in the absence (DMSO) or presence of BTP2. Time stamp, min:sec. Fire LUT, Fura-2 340/380-ratio. Scale bar, 10 µm.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b25844390e3b96508d96f7ee7a83aa
https://doi.org/10.1158/2326-6066.22544286
https://doi.org/10.1158/2326-6066.22544286
Autor:
Peter Friedl, Bettina Weigelin, Carl G. Figdor, Jeroen A. van der Laak, Tonke K. Raaijmakers, Louis Wolf, Esther Wagena, Cindy E. Dieteren, Jeroen Slaats
Cytotoxic T lymphocytes (CTL) mediate cytotoxicity toward tumor cells by multistep cell–cell interactions. However, the tumor microenvironment can metabolically perturb local CTL effector function. CTL activity is typically studied in two-dimension
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7bd87e7ac65a6e963fa33742d719f7
https://doi.org/10.1158/2326-6066.c.6550599.v1
https://doi.org/10.1158/2326-6066.c.6550599.v1
Autor:
Peter Friedl, Bettina Weigelin, Carl G. Figdor, Jeroen A. van der Laak, Tonke K. Raaijmakers, Louis Wolf, Esther Wagena, Cindy E. Dieteren, Jeroen Slaats
OT-I CTL conjugation with B16F10/OVA cells in the absence (left) or presence (right) of 100 µM H2O2. Morgenstemning LUT, Fura-2 340/380-ratio. Time stamp, min:sec (0 min denoting the timepoint of contact initiation). Scale bar, 10 µm.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::181e5b94c4ed2898a9fa5d100533deeb
https://doi.org/10.1158/2326-6066.22544295.v1
https://doi.org/10.1158/2326-6066.22544295.v1
Autor:
Peter Friedl, Bettina Weigelin, Carl G. Figdor, Jeroen A. van der Laak, Tonke K. Raaijmakers, Louis Wolf, Esther Wagena, Cindy E. Dieteren, Jeroen Slaats
OT-I CTLs engaging with and detaching from B16F10/OVA cells in 2D matrix-free or 3D interface co-culture. Note the frequent instable interactions in 2D matrix-free co-culture but not in 3D interface culture. Time stamp, h:min:sec. Scale bar, 10 µm.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a40e7a52505461efd34e3904641a73
https://doi.org/10.1158/2326-6066.22544298.v1
https://doi.org/10.1158/2326-6066.22544298.v1