Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Tonje S Steigedal"'
Autor:
Linn-Karina M Selvik, Shalini Rao, Tonje S Steigedal, Ildri Haltbakk, Kristine Misund, Torunn Bruland, Wenche S Prestvik, Astrid Lægreid, Liv Thommesen
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112485 (2014)
Salt-inducible kinase 1 (SIK1/Snf1lk) belongs to the AMP-activated protein kinase (AMPK) family of kinases, all of which play major roles in regulating metabolism and cell growth. Recent studies have shown that reduced levels of SIK1 are associated w
Externí odkaz:
https://doaj.org/article/c69c5cdade9b424298d2bd7440a596f8
Autor:
Åsmund Flobak, John Zobolas, Miguel Vazquez, Tonje S. Steigedal, Liv Thommesen, Asle Grislingås, Barbara Niederdorfer, Evelina Folkesson, Martin Kuiper
Publikováno v:
Frontiers in Systems Biology, Vol 3 (2023)
Treatment with combinations of drugs carries great promise for personalized therapy for a variety of diseases. We have previously shown that synergistic combinations of cancer signaling inhibitors can be identified based on a logical framework, by ma
Externí odkaz:
https://doaj.org/article/aaa85615ca6e41e4903f1202121a5938
Publikováno v:
FEBS Open Bio, Vol 8, Iss 12, Pp 1992-2001 (2018)
Nephronectin (NPNT) is an extracellular matrix (ECM) protein involved in kidney development. We recently reported intracellular NPNT as a potential prognostic marker in breast cancer and that NPNT promotes metastasis in an integrin‐dependent manner
Externí odkaz:
https://doaj.org/article/86a6a4bbf597415fb83284f10a3b316d
Autor:
Camilla Wolowczyk, Ulrike Neckmann, Miriam Ragle Aure, Martina Hall, Bjarne Johannessen, Sen Zhao, Rolf I. Skotheim, Sonja B. Andersen, Rosalie Zwiggelaar, Tonje S. Steigedal, Ole Christian Lingjærde, Kristine Kleivi Sahlberg, Eivind Almaas, Geir Bjørkøy
Publikováno v:
Free Radical Biology & Medicine
Many breast cancer patients are diagnosed with small, well-differentiated, hormone receptor-positive tumors. Risk of relapse is not easily identified in these patients, resulting in overtreatment. To identify metastasis-related gene expression patter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9508f3d7cb85786406a5f9ea4aeb3583
https://pubmed.ncbi.nlm.nih.gov/35381325
https://pubmed.ncbi.nlm.nih.gov/35381325
Autor:
Animesh Sharma, Voin Petrovic, Marit Otterlei, Tonje S. Steigedal, Caroline Krogh Søgaard, Nina-Beate Liabakk, Anala Nepal
Publikováno v:
Oncotarget
OncoTarget
OncoTarget
Receptor tyrosine kinases (RTKs), such as HER2 and/or EGFR are important therapeutic targets in multiple cancer cells. Low and/or short response to targeted therapies are often due to activation of compensatory signaling pathways, and therefore a com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d532beee389276a860316264bc48a469
http://europepmc.org/articles/PMC6944453
http://europepmc.org/articles/PMC6944453
Logical modeling: Combining manual curation and automated parameterization to predict drug synergies
Autor:
Grislingås A, John Zobolas, Tonje S. Steigedal, Miguel Vazquez, Åsmund Flobak, Liv Thommesen, Barbara Niederdorfer, Evelina Folkesson, Martin Kuiper
Treatment with drug combinations carries great promise for personalized therapy. We have previously shown that drug synergies targeting cancer can manually be identified based on a logical framework. We now demonstrate how automated adjustments of mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c07847d5dcad23a10af7472153d368e9
https://doi.org/10.1101/2021.06.28.450165
https://doi.org/10.1101/2021.06.28.450165
Autor:
Synnøve Magnussen, Elin Synnøve Hadler-Olsen, Tonje S. Steigedal, Gunbjørg Svineng, Jimita Prashant Toraskar
Publikováno v:
Cancers, Vol 13, Iss 959, p 959 (2021)
13:959
Cancers
13:959
Cancers
Simple Summary The extracellular matrix provides an important scaffold for cells and tissues of multicellular organisms. The scaffold not only provides a secure anchorage point, but also functions as a reservoir for signalling molecules, sequestered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84ea2f82e4331d4fc2e8c2c87fb3d2ae
https://hdl.handle.net/10037/21864
https://hdl.handle.net/10037/21864
Autor:
Stine Figenschau, János Haskó, Marit Seppola, Imola Wilhelm, Gunbjørg Svineng, Synnøve Magnussen, Judit Molnár, Tonje S. Steigedal, Elin Synnøve Hadler-Olsen, Jimita Prashant Toraskar, István A. Krizbai, Sonja E. Steigen
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
This study demonstrates a role for the extracellular matrix protein nephronectin (NPNT) in promoting experimental breast cancer brain metastasis, possibly through enhanced binding to- and migration through brain endothelial cells. With the introducti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f8d66b275e0a8d38a06bf8d6d8b834
https://hdl.handle.net/10037/18912
https://hdl.handle.net/10037/18912
Autor:
Catherine Taylor Nordgård, Shalini V. Rao, Frances M. Richards, Sabina P. Strand, Duncan I. Jodrell, Aarthi Gopinathan, Tonje S. Steigedal, Kurt Ingar Draget
Publikováno v:
Pancreatology. 20:e8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af042e38e27a544bb02c4d18c9b0f912
https://doi.org/10.1016/j.pan.2018.10.035
https://doi.org/10.1016/j.pan.2018.10.035
Autor:
Linh Hoang, Gunbjørg Svineng, Synnøve Magnussen, Animesh Sharma, Geir Bjørkøy, Lars Hagen, Jimita Prashant Toraskar, Tonje S. Steigedal
Publikováno v:
Journal of Proteome Research
Extracellular vesicles are emerging as biomarkers in breast cancer. Our recent report suggested that an intracellular granular staining pattern of the extracellular matrix protein nephronectin (NPNT) in breast tumor sections correlated with a poor pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac60d96070c1859b2860631b96595a8d
https://hdl.handle.net/11250/2639720
https://hdl.handle.net/11250/2639720