Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Tonio Pera"'
Autor:
Eric Tompkins, Bogdana Mimic, Karina Cuevas-Mora, Hannah Schorsch, Sushrut D. Shah, Deepak A. Deshpande, Jeffrey L. Benovic, Raymond B. Penn, Tonio Pera
Publikováno v:
American journal of respiratory cell and molecular biology. 67(5)
G protein-coupled receptors (GPCRs) not only are turned on or off to control canonical G protein signaling but also may be fine-tuned to promote qualitative/biased signaling. Qualitative signaling by M3 muscarinic acetylcholine receptors (mAChRs) has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18dfa70cba1c1b85e45ee436e9a8d848
https://pubmed.ncbi.nlm.nih.gov/36049223
https://pubmed.ncbi.nlm.nih.gov/36049223
Publikováno v:
Comprehensive Pharmacology ISBN: 9780128208762
Reference Module in Biomedical Sciences
Reference Module in Biomedical Sciences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b72f172c716550086f362ec748b865e1
https://doi.org/10.1016/b978-0-12-820472-6.00095-5
https://doi.org/10.1016/b978-0-12-820472-6.00095-5
Autor:
Tonio Pera, Catrin Bitter, David Wright, Maarten van den Berge, Herman Meurs, Pavan Prabhala, Wim Timens, Bart G. J. Dekkers, Nick H. T. ten Hacken, P. Robbe
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology, 317(6), L768-L777. AMER PHYSIOLOGICAL SOC
Airway inflammation and remodeling are characteristic features of asthma, with both contributing to airway hyperresponsiveness (AHR) and lung function limitation. Airway smooth muscle (ASM) accumulation and extracellular matrix deposition are charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6829d65f1c9f9d18bfeb48a2e6637a04
https://doi.org/10.1152/ajplung.00222.2019
https://doi.org/10.1152/ajplung.00222.2019
Autor:
Tonio Pera, Edward J. Weinman, Deepak A. Deshpande, Bin Wang, Michael Katz, Eric Tompkins, Raymond B. Penn
Publikováno v:
FASEB J
Na(+)/H(+) exchanger regulatory factor 1 (NHERF1; also known as ezrin-radixin-moesin–binding phosphoprotein 50) is a PSD-95, disc large, zona occludens-1 adapter that acts as a scaffold for signaling complexes and cytoskeletal-plasma membrane inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cee6a314c1061bb174f57290d6a1264
https://doi.org/10.1096/fj.201900323r
https://doi.org/10.1096/fj.201900323r
Publikováno v:
B108. NEW INSIGHTS INTO AIRWAY REMODELLING AND REPAIR.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6291a635b55692262d69c1c450a3ff0a
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4411
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4411
Publikováno v:
Current Opinion in Pharmacology. 40:120-125
Current therapies to treat asthma and other airway diseases primarily include anti-inflammatory agents and bronchodilators. Anti-inflammatory agents target trafficking and resident immunocytes and structural cells, while bronchodilators act to preven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c47f981180d8eebe6e8ed7de6f66312
https://doi.org/10.1016/j.coph.2018.04.008
https://doi.org/10.1016/j.coph.2018.04.008
Autor:
Ajay P. Nayak, Eleni Farrell, Deepak A. Deshpande, Adelina Gavrila, Wesley K. Kroeze, Eric Tompkins, Bryan L. Roth, Nickolai O. Dulin, Tonio Pera, James V. Michael, Bin Wang, Jeffrey L. Benovic, Raymond B. Penn, Steven S. An, Michael Ippolito, Reynold A. Panettieri
Publikováno v:
The FASEB Journal. 32:862-874
GPCRs have diverse signaling capabilities, based on their ability to assume various conformations. Moreover, it is now appreciated that certain ligands can promote distinct receptor conformations and thereby bias signaling toward a specific pathway t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6036754d7eb23e5fb2d03427f938052
https://doi.org/10.1096/fj.201700555r
https://doi.org/10.1096/fj.201700555r
Publikováno v:
B29. MECHANISMS FOR AIRWAY HYPERRESPONSIVENESS: FROM CELL TO ORGANISM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::680cadea621b58f655098c7e8178c96d
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2849
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2849
Methods to Investigate β-Arrestin-Mediated Regulation of GPCR Function in Human Airway Smooth Muscle
Autor:
Tonio Pera, Raymond B. Penn
Publikováno v:
Beta-Arrestins ISBN: 9781493991570
Arrestin proteins were originally characterized as regulators of GPCR desensitization, and that function alone was sufficient to promote extreme interest in their study. It is now appreciated that arrestins also function as mediators of GPCR traffick
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e82541a337cf33835813120ae3a65d
https://pubmed.ncbi.nlm.nih.gov/30919347
https://pubmed.ncbi.nlm.nih.gov/30919347
Autor:
Deepak A. Deshpande, Ajay P. Nayak, Henry P. Morelli, Shi Pan, Jennifer R. Liberato, Nadan Wang, Tonio Pera, Eric Tompkins, James V. Michael, Roslyn Yi, Raymond B. Penn
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Ovarian cancer G protein-coupled receptor 1 (OGR1) is a recently deorphanized G protein-coupled receptor shown to signal in response to low extracellular pH (↓pHo) or certain benzodiazepines. The pleiotropic nature of OGR1 signaling in human airway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d2dc98aa718aad6d5afd5af4bf86fe
https://europepmc.org/articles/PMC6589584/
https://europepmc.org/articles/PMC6589584/