Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP -Deleted Cancers.

Autor: Cottrell KM; Tango Therapeutics, Boston, Massachusetts 02215, United States., Briggs KJ; Tango Therapeutics, Boston, Massachusetts 02215, United States., Whittington DA; Tango Therapeutics, Boston, Massachusetts 02215, United States., Jahic H; Tango Therapeutics, Boston, Massachusetts 02215, United States., Ali JA; Tango Therapeutics, Boston, Massachusetts 02215, United States., Davis CB; Tango Therapeutics, Boston, Massachusetts 02215, United States., Gong S; Tango Therapeutics, Boston, Massachusetts 02215, United States., Gotur D; Tango Therapeutics, Boston, Massachusetts 02215, United States., Gu L; Tango Therapeutics, Boston, Massachusetts 02215, United States., McCarren P; Tango Therapeutics, Boston, Massachusetts 02215, United States., Tonini MR; Tango Therapeutics, Boston, Massachusetts 02215, United States., Tsai A; Tango Therapeutics, Boston, Massachusetts 02215, United States., Wilker EW; Tango Therapeutics, Boston, Massachusetts 02215, United States., Yuan H; Tango Therapeutics, Boston, Massachusetts 02215, United States., Zhang M; Tango Therapeutics, Boston, Massachusetts 02215, United States., Zhang W; Tango Therapeutics, Boston, Massachusetts 02215, United States., Huang A; Tango Therapeutics, Boston, Massachusetts 02215, United States., Maxwell JP; Tango Therapeutics, Boston, Massachusetts 02215, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Apr 25; Vol. 67 (8), pp. 6064-6080. Date of Electronic Publication: 2024 Apr 10.