Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Tonia S, Rex"'
Autor:
Tonia S. Rex, David J. Calkins
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 2, Pp 489-490 (2025)
Externí odkaz:
https://doaj.org/article/4c7ae4711bc84adf939ab1aa4482d334
Autor:
Sarah Naguib, Jon R. Backstrom, Elisabeth Artis, Purnima Ghose, Amy Stahl, Rachael Hardin, Ameer A. Haider, John Ang, David J. Calkins, Tonia S. Rex
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-15 (2023)
Abstract Glaucoma, the second leading cause of irreversible blindness worldwide, is associated with age and sensitivity to intraocular pressure (IOP). We have shown that elevated IOP causes an early increase in levels of reactive oxygen species (ROS)
Externí odkaz:
https://doaj.org/article/822803ba53aa43a396111c625495ec4e
Autor:
Chloe N. Thomas, Alexandra Bernardo-Colón, Ella Courtie, Gareth Essex, Tonia S. Rex, Richard J. Blanch, Zubair Ahmed
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Ocular repeated air blast injuries occur from low overpressure blast wave exposure, which are often repeated and in quick succession. We have shown that caspase-2 caused the death of retinal ganglion cells (RGC) after blunt ocular trauma. He
Externí odkaz:
https://doaj.org/article/5b1afdd3ed344166bd25ff7af7659085
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 139-148 (2020)
The power of CRISPRi to decrease targeted gene expression for clinical applications has been inhibited by delivery challenges. Existing constructs are too large to fit within the ∼4.7 kb packaging size limitation of adeno-associated virus (AAV), th
Externí odkaz:
https://doaj.org/article/e62d5d2d855a481eac4ae831ee2cf1cb
Autor:
Sarah Naguib, Carlisle R. DeJulius, Jon R. Backstrom, Ameer A. Haider, John M. Ang, Andrew M. Boal, David J. Calkins, Craig L. Duvall, Tonia S. Rex
Publikováno v:
Antioxidants, Vol 12, Iss 3, p 556 (2023)
Erythropoietin (EPO) is neuroprotective in multiple models of neurodegenerative diseases, including glaucoma. EPO-R76E retains the neuroprotective effects of EPO but diminishes the effects on hematocrit. Treatment with EPO-R76E in a glaucoma model in
Externí odkaz:
https://doaj.org/article/f425def142764bd78d4e216706b866ad
cGMP Signaling in the Neurovascular Unit—Implications for Retinal Ganglion Cell Survival in Glaucoma
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1671 (2022)
Glaucoma is a progressive age-related disease of the visual system and the leading cause of irreversible blindness worldwide. Currently, intraocular pressure (IOP) is the only modifiable risk factor for the disease, but even as IOP is lowered, the pa
Externí odkaz:
https://doaj.org/article/5948df5d70f7435388b58d64f2c24888
Publikováno v:
Redox Biology, Vol 42, Iss , Pp 101883- (2021)
Oxidative stress contributes to degeneration of retinal ganglion cells and their axons in glaucoma, a leading cause of irreversible blindness worldwide, through sensitivity to intraocular pressure (IOP). Here, we investigated early elevations in reac
Externí odkaz:
https://doaj.org/article/f0c61944a99e41a99ed82ef87ae19a2b
Autor:
Joseph M. Holden, Sara Al Hussein Al Awamlh, Louis-Philippe Croteau, Andrew M. Boal, Tonia S. Rex, Michael L. Risner, David J. Calkins, Lauren K. Wareham
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 3066 (2022)
The nitric oxide–guanylyl cyclase-1–cyclic guanylate monophosphate (NO–GC-1–cGMP) pathway is integral to the control of vascular tone and morphology. Mice lacking the alpha catalytic domain of guanylate cyclase (GC1−/−) develop retinal ga
Externí odkaz:
https://doaj.org/article/f267cc491cb14b9ba48426fddd832d27
Publikováno v:
Neurobiology of Disease, Vol 134, Iss , Pp - (2020)
Our goal was to investigate the neuroprotective effects of galantamine in a mouse model of blast-induced indirect traumatic optic neuropathy (bITON). Galantamine is an FDA-approved acetylcholinesterase inhibitor used to treat mild-moderate Alzheimer'
Externí odkaz:
https://doaj.org/article/804a7522fff24b79b726440a94f10209
Autor:
Alexandra Bernardo-Colón, Victoria Vest, Melissa L. Cooper, Sarah A. Naguib, David J. Calkins, Tonia S. Rex
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Indirect traumatic optic neuropathy (ITON) is a condition that is often associated with traumatic brain injury and can result in significant vision loss due to degeneration of retinal ganglion cell (RGC) axons at the time of injury or within the ensu
Externí odkaz:
https://doaj.org/article/79ead76cd86d48029e469df5ecae02ab