Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Tonia K. Tsinman"'
Autor:
Ana P. Peredo, Tonia K. Tsinman, Edward D. Bonnevie, Xi Jiang, Harvey E. Smith, Sarah E. Gullbrand, Nathaniel A. Dyment, Robert L. Mauck
Publikováno v:
JOR Spine, Vol 7, Iss 1, Pp n/a-n/a (2024)
Abstract Introduction Therapeutic interventions for intervertebral disc herniation remain scarce due to the inability of endogenous annulus fibrosus (AF) cells to respond to injury and drive tissue regeneration. Unlike other orthopedic tissues, such
Externí odkaz:
https://doaj.org/article/c7dcee710b2242e1b2f35b713803a2d6
Autor:
Ana P. Peredo, Tonia K. Tsinman, Edward D. Bonnevie, Xi Jiang, Harvey E. Smith, Sarah E. Gullbrand, Nathaniel A. Dyment, Robert L. Mauck
Therapeutic interventions for intervertebral disc herniation remain scarce due to the inability of endogenous annulus fibrosus (AF) cells to respond to injury and drive tissue regeneration. Unlike other orthopaedic tissues, such as cartilage, deliver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::890a12764703fb11a412bc0588602aea
https://doi.org/10.1101/2022.05.06.490483
https://doi.org/10.1101/2022.05.06.490483
Publikováno v:
FASEB J
The incredible mechanical strength and durability of mature fibrous tissues and their extremely limited turnover and regenerative capacity underscores the importance of proper matrix assembly during early postnatal growth. In tissues with composite e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d175dca3aa8abd7a57c7889a4f7d8d
https://doi.org/10.1096/fj.202100499r
https://doi.org/10.1096/fj.202100499r
Autor:
Robert L. Mauck, Tonia K. Tsinman, Harvey E. Smith, Edward D. Bonnevie, Dawn M. Elliott, Sarah E. Gullbrand, Beth G. Ashinsky, Pen-Hsiu Grace Chao
Publikováno v:
Nature biomedical engineering
In fibrous tissues, prestressed boundary constraints at bone interfaces instil residual strain throughout the tissue, even when unloaded. For example, internal swelling pressures in the central nucleus pulposus of the intervertebral disc generate pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f1e5e20dc71936b8ff86b3e80779df9
https://doi.org/10.1038/s41551-019-0458-4
https://doi.org/10.1038/s41551-019-0458-4
The incredible mechanical strength and durability of mature fibrous tissues and their extremely limited turnover and regenerative capacity underscores the importance of proper matrix assembly during early postnatal growth. In tissues with composite e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4002c09926796c1bec66e70dc7914680
https://doi.org/10.1101/2021.02.20.432114
https://doi.org/10.1101/2021.02.20.432114
Autor:
Brian D. Cosgrove, Claudia Loebel, Robert L. Mauck, Eric Dai, Jason A. Burdick, Nathaniel A. Dyment, Tonia K. Tsinman, Tristan P. Driscoll, Su Jin Heo
Publikováno v:
Biomaterials
Exogenous mechanical cues are transmitted from the extracellular matrix to the nuclear envelope (NE), where mechanical stress on the NE mediates shuttling of transcription factors and other signaling cascades that dictate downstream cellular behavior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00d4ad69eb7aad5f30e92bb83dc34be7
https://pubmed.ncbi.nlm.nih.gov/33540172
https://pubmed.ncbi.nlm.nih.gov/33540172