Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Tonia J Buchholz"'
Autor:
Michael B Winter, Florencia La Greca, Shirin Arastu-Kapur, Francesco Caiazza, Peter Cimermancic, Tonia J Buchholz, Janet L Anderl, Matthew Ravalin, Markus F Bohn, Andrej Sali, Anthony J O'Donoghue, Charles S Craik
Publikováno v:
eLife, Vol 6 (2017)
The immunoproteasome (iP) has been proposed to perform specialized roles in MHC class I antigen presentation, cytokine modulation, and T cell differentiation and has emerged as a promising therapeutic target for autoimmune disorders and cancer. Howev
Externí odkaz:
https://doaj.org/article/e24818c8dbee416fbc11f00f86293fde
Autor:
Diego Acosta-Alvear, Min Y Cho, Thomas Wild, Tonia J Buchholz, Alana G Lerner, Olga Simakova, Jamie Hahn, Neha Korde, Ola Landgren, Irina Maric, Chunaram Choudhary, Peter Walter, Jonathan S Weissman, Martin Kampmann
Publikováno v:
eLife, Vol 4 (2015)
Hallmarks of cancer, including rapid growth and aneuploidy, can result in non-oncogene addiction to the proteostasis network that can be exploited clinically. The defining example is the exquisite sensitivity of multiple myeloma (MM) to 20S proteasom
Externí odkaz:
https://doaj.org/article/a66223f80c7441a6863650c2ab840d71
Autor:
Mark K. Bennett, Christopher J. Molineaux, Tina M. Woo, Marcy K. Vallone, Congcong M. Sun, Mark S. Smyth, Kevin D. Shenk, Francesco Parlati, Evan R. Lewis, Guy J. Laidig, Jing Jiang, Mark N. Ho, Maya Dajee, Tonia J. Buchholz, Monette A. Aujay, Christopher J. Kirk, Susan D. Demo
Supplementary Figure 1 from Antitumor Activity of PR-171, a Novel Irreversible Inhibitor of the Proteasome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a101c8883eaf41acd7d210a2605a14a
https://doi.org/10.1158/0008-5472.22367433.v1
https://doi.org/10.1158/0008-5472.22367433.v1
Autor:
Mark K. Bennett, Christopher J. Molineaux, Tina M. Woo, Marcy K. Vallone, Congcong M. Sun, Mark S. Smyth, Kevin D. Shenk, Francesco Parlati, Evan R. Lewis, Guy J. Laidig, Jing Jiang, Mark N. Ho, Maya Dajee, Tonia J. Buchholz, Monette A. Aujay, Christopher J. Kirk, Susan D. Demo
Supplementary Figure 2 from Antitumor Activity of PR-171, a Novel Irreversible Inhibitor of the Proteasome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6bf03b50a24a2f24a2702fa914794b3
https://doi.org/10.1158/0008-5472.22367430.v1
https://doi.org/10.1158/0008-5472.22367430.v1
Autor:
Mark K. Bennett, Christopher J. Molineaux, Tina M. Woo, Marcy K. Vallone, Congcong M. Sun, Mark S. Smyth, Kevin D. Shenk, Francesco Parlati, Evan R. Lewis, Guy J. Laidig, Jing Jiang, Mark N. Ho, Maya Dajee, Tonia J. Buchholz, Monette A. Aujay, Christopher J. Kirk, Susan D. Demo
Clinical studies with bortezomib have validated the proteasome as a therapeutic target for the treatment of multiple myeloma and non-Hodgkin's lymphoma. However, significant toxicities have restricted the intensity of bortezomib dosing. Here we descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47fe217774fa4900e95086b10a5be1f2
https://doi.org/10.1158/0008-5472.c.6495546.v1
https://doi.org/10.1158/0008-5472.c.6495546.v1
Autor:
Susan Bal, M. Hakan Kocoglu, Omar Nadeem, Myo Htut, Tara Gregory, Larry D. Anderson, Luciano J. Costa, Tonia J. Buchholz, Safiyyah Ziyad, Meng Li, Yanping Chen, Allison J. Kaeding, Michael R. Burgess, Kristen Hege, Jesus Berdeja
Publikováno v:
Blood. 140:883-885
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e47a146d519601ecaf56ecef99b9b913
https://doi.org/10.1182/blood-2022-162395
https://doi.org/10.1182/blood-2022-162395
Autor:
Julio C. Chavez, Jean-Marie Michot, Cecilia Carpio, Silvia Ferrari, Tatyana A. Feldman, Daniel Morillo, John Kuruvilla, Antonio Pinto, Vincent Ribrag, Emmanuel Bachy, Tonia J. Buchholz, Soraya Carrancio, Wen-Chi Chou, Carla Guarinos, Fan Wu, Shaoyi Li, Poliana Patah, Michael Pourdehnad, Loretta Nastoupil
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 22:S377-S378
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b4521ff9625b9b2c1e5a88f806fba59
https://doi.org/10.1016/s2152-2650(22)01538-5
https://doi.org/10.1016/s2152-2650(22)01538-5
Autor:
Julio C. Chavez, Jean-Marie Michot, Cecilia Carpio, Silvia Ferrari, Tatyana A. Feldman, Daniel Morillo, John Kuruvilla, Antonio Pinto, Vincent Ribrag, Emmanuel Bachy, Tonia J. Buchholz, Soraya Carrancio, Wen-Chi Chou, Carla Guarinos, Fan Wu, Shaoyi Li, Poliana Patah, Michael Pourdehnad, Loretta Nastoupil
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 22:S165
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e339f66cf8e4ceeb3e9b562e3afecbc
https://doi.org/10.1016/s2152-2650(22)01009-6
https://doi.org/10.1016/s2152-2650(22)01009-6
Autor:
Silvia Ferrari, Antonio Pinto, Kasibhatla Shailaja, F. Wu, Cecilia Carpio, Tatyana Feldman, L. J. Nastoupil, Michael Pourdehnad, Soraya Carrancio, Emmanuel Bachy, Carla Guarinos, Julio C. Chavez, Poliana Patah, D. Morillo, S. Li, J-M. Michot, Tonia J. Buchholz, John Kuruvilla
Publikováno v:
Hematological Oncology. 39
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::271669edcfb7f2b7a4ebd04d37c0c04a
https://doi.org/10.1002/hon.89_2881
https://doi.org/10.1002/hon.89_2881
Autor:
Soraya Carrancio, Daniel Morillo, Cecilia Carpio, Tatyana Feldman, Shaoyi Li, Michael Pourdehnad, Poliana Patah, Julio C. Chavez, Emmanuel Bachy, Carla Guarinos, Antonio Pinto, Fan Wu, Jean-Marie Michot, Loretta J. Nastoupil, John Kuruvilla, Tonia J. Buchholz, Silvia Ferrari, Vincent Ribrag
Publikováno v:
Blood. 138:3574-3574
CC-99282 is a novel, small molecule CELMoD ® agent that co-opts cereblon to induce targeted degradation of Ikaros/Aiolos, transcription factors critical for development of B-cell malignancies. Lopez-Girona et al. reported that in preclinical models,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2311d150957c8cbbeaa909badde00343
https://doi.org/10.1182/blood-2021-147333
https://doi.org/10.1182/blood-2021-147333