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Chelatable cellular copper modulates differentiation and self-renewal of cord blood-derived hematopoietic progenitor cells

Autor: Eitan Fibach, Sophie Adi, Harel Assor, Toni Peled, Elina Glukhman, Julie Mandel, Arnon Nagler, Efrat Landau, Nira Hasson, Chana Landor, Eugenia Prus, Dima Yudin

Publikováno v: Experimental hematology. 33(10)

Objectives We have demonstrated epigenetic modulation of CD34 + cell differentiation by the high-affinity copper (Cu) chelator tetraethylenepentamine (TEPA). TEPA slowed down the rate of CD34 + cell differentiation and increased their engraftability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6850626bd662d5fa4fe7c2c4a96d4bc
https://pubmed.ncbi.nlm.nih.gov/16219531

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Linear polyamine copper chelator tetraethylenepentamine augments long-term ex vivo expansion of cord blood-derived CD34+ cells and increases their engraftment potential in NOD/SCID mice

Autor: Elina Glukhman, Julie Mandel, Efrat Landau, Eitan Fibach, Arnon Nagler, Noga R. Goudsmid, Toni Peled

Publikováno v: Experimental hematology. 32(6)

Objective We previously demonstrated that cellular copper is involved in the regulation of proliferation and differentiation of hematopoietic progenitor cells. Modulation of cellular copper was achieved by supplementing the culture with a copper chel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544e8511a5f469bcd7ff212d3e5fcbc0
https://pubmed.ncbi.nlm.nih.gov/15183895

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Cell Cycle Progression and Self-Renewal Divisions of Cord Blood Derived CD34+ Cells Treated with the Polyamine Copper-Chelator Tetraethylenepentamine

Autor: Sophie Adi, Toni Peled, Noga R. Goudsmid, Arnon Nagler, Frida Grynspan, Efrat Landau, Eitan Fibach, Yaron Daniely

Publikováno v: Blood. 104:4237-4237

In vitro cell expansion is constrained by default pathways of commitment and differentiation resulting in limited expansion of hematopoietic stem-progenitor cells (HSPCs). Still, several ex vivo manipulations have been reported to achieve expansion o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::acbe7de795f26340025bcb086fa6eedf
https://doi.org/10.1182/blood.v104.11.4237.4237

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Nicotinamide, a Potent SIRT2 Inhibitor, Delays Differentiation of Hematopoietic Progenitor Cells

Autor: Sophie Adi, Eitan Fibach, Frida Grynspan, Yaron Daniely, Elina Glukhman, Toni Peled, Arnon Nagler

Publikováno v: Blood. 104:4142-4142

CD38, originally described as a differentiation marker, has emerged as an important multifunctional transmembrane protein. Its most intriguing and well-characterized function is its ability to catalyze the synthesis of cyclic ADP-ribose (cADPR) from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b2901fe29462d327c579f48eec91160
https://doi.org/10.1182/blood.v104.11.4142.4142

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