Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Toni Delorey"'
Autor:
Yunpeng Liu-Lupo, James Dongjoo Ham, Swarna K. A. Jeewajee, Lan Nguyen, Toni Delorey, Azucena Ramos, David M. Weinstock, Aviv Regev, Michael T. Hemann
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Whole chromosome losses resulting in near-haploid karyotypes are found in a rare subgroup of treatment-refractory acute lymphoblastic leukemia. To systematically dissect the unique physiology and uncover susceptibilities that can be exploite
Externí odkaz:
https://doaj.org/article/acda13bfd53946019651b06a170fb474
Autor:
José F. Muñoz, Toni Delorey, Christopher B. Ford, Bi Yu Li, Dawn A. Thompson, Reeta P. Rao, Christina A. Cuomo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The outcomes of the interactions between individual host cells and pathogens are heterogeneous. Here, the authors assess transcriptional variability in both host and pathogen during infection of macrophages with the fungus Candida albicans, using sor
Externí odkaz:
https://doaj.org/article/ed4108988c524bcc93a97e3410c423b9
Autor:
Rhys A. Farrer, Christopher B. Ford, Johanna Rhodes, Toni Delorey, Robin C. May, Matthew C. Fisher, Elaine Cloutman-Green, Francois Balloux, Christina A. Cuomo
Publikováno v:
mSphere, Vol 3, Iss 5 (2018)
ABSTRACT Cryptococcus gattii is a pathogenic yeast of humans and other animals which causes disease predominantly in immunocompetent hosts. Infection begins when aerosolized yeast or spores enter the body, triggering an immune response, including eng
Externí odkaz:
https://doaj.org/article/6e68a9721caa4eaca8e2abf7fd098260
Autor:
Christopher B Ford, Jason M Funt, Darren Abbey, Luca Issi, Candace Guiducci, Diego A Martinez, Toni Delorey, Bi yu Li, Theodore C White, Christina Cuomo, Reeta P Rao, Judith Berman, Dawn A Thompson, Aviv Regev
Publikováno v:
eLife, Vol 4 (2015)
Candida albicans is both a member of the healthy human microbiome and a major pathogen in immunocompromised individuals. Infections are typically treated with azole inhibitors of ergosterol biosynthesis often leading to drug resistance. Studies in cl
Externí odkaz:
https://doaj.org/article/24a30f36045c4e68b7ec1778825dc6ed
Autor:
Kathryn Geiger-Schuller, Basak Eraslan, Olena Kuksenko, Kushal K. Dey, Karthik A. Jagadeesh, Pratiksha I. Thakore, Ozge Karayel, Andrea R. Yung, Anugraha Rajagopalan, Ana M Meireles, Karren Dai Yang, Liat Amir-Zilberstein, Toni Delorey, Devan Phillips, Raktima Raychowdhury, Christine Moussion, Alkes L. Price, Nir Hacohen, John G. Doench, Caroline Uhler, Orit Rozenblatt-Rosen, Aviv Regev
Publikováno v:
bioRxiv
E3 ligases regulate key processes, but many of their roles remain unknown. Using Perturb-seq, we interrogated the function of 1,130 E3 ligases, partners and substrates in the inflammatory response in primary dendritic cells (DCs). Dozens impacted the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d8f305a048b8acb0f805d0af1ceb7e
https://europepmc.org/articles/PMC9900845/
https://europepmc.org/articles/PMC9900845/
Autor:
William L. Hwang, Karthik A. Jagadeesh, Jimmy A. Guo, Hannah I. Hoffman, Carina Shiau, Jennifer Su, Payman Yadollahpour, Jason W. Reeves, Youngmi Kim, Sean Kim, Mark Gregory, Prajan Divakar, Eric Miller, Michael Rhodes, Sarah Warren, Erroll Rueckert, Kit Fuhrman, Daniel R. Zollinger, Robin Fropf, Joseph M. Beechem, Arnav Mehta, Toni Delorey, Cristin McCabe, Jaimie L. Barth, Piotr Zelga, Cristina R. Ferrone, Motaz Qadan, Keith D. Lillemoe, Rakesh K. Jain, Jennifer Y. Wo, Theodore S. Hong, Ramnik Xavier, Orit Rozenblatt-Rosen, Andrew J. Aguirre, Carlos Fernandez-Del Castillo, Andrew S. Liss, Mari Mino-Kenudson, David T. Ting, Tyler Jacks, Aviv Regev
Publikováno v:
Cancer Research. 82:SY12-04
Pancreatic ductal adenocarcinoma (PDAC) is projected to be the second leading cause of cancer mortality in the United States by 2030. Given that resistance to cytotoxic therapy is pervasive, there is a critical need to elucidate salient gene expressi
Autor:
Inbal Avraham-Davidi, Simon Mages, Johanna Klughammer, Noa Moriel, Shinya Imada, Matan Hofree, Evan Murray, Jonathan Chen, Karin Pelka, Arnav Mehta, Genevieve M. Boland, Toni Delorey, Leah Caplan, Danielle Dionne, Itay Tirosh, Nir Hacohen, Fei Chen, Omer Yilmaz, Jatin Roper, Orit Rozenblatt-Rosen, Mor Nitzan, Aviv Regev
While advances in single cell genomics have helped to chart the cellular components of tumor ecosystems, it has been more challenging to characterize their specific spatial organization and functional interactions. Here, we combine single cell RNA-se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f29eadadcd40e1cf9e610726b6595443
https://doi.org/10.1101/2022.10.02.508492
https://doi.org/10.1101/2022.10.02.508492
Autor:
William L. Hwang, Karthik A. Jagadeesh, Jimmy A. Guo, Hannah I. Hoffman, Payman Yadollahpour, Jason W. Reeves, Rahul Mohan, Eugene Drokhlyansky, Nicholas Van Wittenberghe, Orr Ashenberg, Samouil L. Farhi, Denis Schapiro, Prajan Divakar, Eric Miller, Daniel R. Zollinger, George Eng, Jason M. Schenkel, Jennifer Su, Carina Shiau, Patrick Yu, William A. Freed-Pastor, Domenic Abbondanza, Arnav Mehta, Joshua Gould, Conner Lambden, Caroline B. M. Porter, Alexander Tsankov, Danielle Dionne, Julia Waldman, Michael S. Cuoco, Lan Nguyen, Toni Delorey, Devan Phillips, Jaimie L. Barth, Marina Kem, Clifton Rodrigues, Debora Ciprani, Jorge Roldan, Piotr Zelga, Vjola Jorgji, Jonathan H. Chen, Zackery Ely, Daniel Zhao, Kit Fuhrman, Robin Fropf, Joseph M. Beechem, Jay S. Loeffler, David P. Ryan, Colin D. Weekes, Cristina R. Ferrone, Motaz Qadan, Martin J. Aryee, Rakesh K. Jain, Donna S. Neuberg, Jennifer Y. Wo, Theodore S. Hong, Ramnik Xavier, Andrew J. Aguirre, Orit Rozenblatt-Rosen, Mari Mino-Kenudson, Carlos Fernandez-del Castillo, Andrew S. Liss, David T. Ting, Tyler Jacks, Aviv Regev
Publikováno v:
Nat Genet
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal and treatment-refractory cancer. Molecular stratification in pancreatic cancer remains rudimentary and does not yet inform clinical management or therapeutic development. Here, we construct a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52fea7e3e72f452826d1f68df747811
https://europepmc.org/articles/PMC10290535/
https://europepmc.org/articles/PMC10290535/
Autor:
Basak Eraslan, Eric Brown, Maura Benson, Liat Amir-Zilberstein, Sung-Moo Park, Betsabeh Tusi, Vladislav Pokatayev, Cody Hecht, Novalia Pishesha, Devan Phillips, Andy Kim, Shuting Zhang, Anthony Gaca, Fadi Ghantous, Toni Delorey, Jonathan Livny, Lindsey Baden, Orit Rozenblatt-Rosen, Daniel Graham, Aviv Regev, Michael Seaman, Ann Woolley, Lisa Cosimi, Deborah Hung, Jacques Deguine, Ramnik Xavier
Publikováno v:
Research square.
SARS-CoV-2 infection leads to a broad range of outcomes and immune responses, with the development of neutralizing antibodies generally correlated with protection against reinfection. Here, we have characterized both neutralizing activity and T cell
Autor:
Jason M. Schenkel, Prajan Divakar, Alex M. Jaeger, Ana P. Garcia, Peter M. K. Westcott, Tyler Hether, Zackery A. Ely, Roderick T. Bronson, Laurens J. Lambert, Jason Reeves, William A. Freed-Pastor, Devan Phillips, Vikram Deshpande, Arjun Bhutkar, Kim L. Mercer, Ömer H. Yilmaz, Tyler Jacks, George Eng, Lin Lin, William L. Hwang, Nimisha B. Pattada, Aviv Regev, Toni Delorey, William M. Rideout
Publikováno v:
Cancer Cell
Summary The CD155/TIGIT axis can be co-opted during immune evasion in chronic viral infections and cancer. Pancreatic adenocarcinoma (PDAC) is a highly lethal malignancy, and immune-based strategies to combat this disease have been largely unsuccessf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b53f9987c16263228fdea161ccfed14
https://europepmc.org/articles/PMC8511341/
https://europepmc.org/articles/PMC8511341/