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Autor:
Toni A. Petty, Joan M. Caroon, Mcclelland Deborah L, A. D. Michel, Robin D. Clark, Rosenkranz Roberto P, L. David Waterbury, Nancy E. Isaac
Publikováno v:
Journal of pharmaceutical sciences. 76(5)
A series of analogues of N,N-di-n-propyldopamine (DPDA) in which the 3-hydroxyl group was replaced by bioisosteric groups was prepared and evaluated for D1- and D2-receptor affinity. The 3-methane-sulfonamide analogue (18) had a higher affinity for t