Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Tongying Shun"'
Autor:
Jordan Sanders, Michael Castiglione, Tongying Shun, Laura L. Vollmer, Mark E. Schurdak, Andreas Vogt, Anthony Schwacha
Publikováno v:
SLAS Discovery, Vol 27, Iss 4, Pp 229-241 (2022)
Mcm2-7 is the catalytic core of the eukaryotic replicative helicase, which together with CDC45 and the GINS complex unwind parental DNA to generate templates for DNA polymerase. Being a highly regulated and complex enzyme that operates via an incompl
Externí odkaz:
https://doaj.org/article/dace82500f2d426da52ccee7a1d3e830
Autor:
Elizabeth R Sharlow, David Close, Tongying Shun, Stephanie Leimgruber, Robyn Reed, Gabriela Mustata, Peter Wipf, Jacob Johnson, Michael O'Neil, Max Grögl, Alan J Magill, John S Lazo
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 3, Iss 11, p e540 (2009)
Patients with clinical manifestations of leishmaniasis, including cutaneous leishmaniasis, have limited treatment options, and existing therapies frequently have significant untoward liabilities. Rapid expansion in the diversity of available cutaneou
Externí odkaz:
https://doaj.org/article/c6139b906ed940fd9c9f303cbc69cf8b
Autor:
VINNY NEGI, DILLON GAVLOCK, JEONGKYUNG LEE, TONGYING SHUN, ALBERT GOUGH, MARK T. MIEDEL, D. LANSING L. TAYLOR, VIJAY YECHOOR
Publikováno v:
Diabetes. 71
The COVID-pandemic has contributed to more than 5 million deaths worldwide in the last two years. Co-morbid conditions such as Type 2 Diabetes (T2D) , HTN, obesity, and CKD have been associated with increased mortality with COVID-19. In a large meta-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cbdf996ea9222163a22328a3e13131c
https://doi.org/10.2337/db22-831-p
https://doi.org/10.2337/db22-831-p
Autor:
Paul A. Johnston, Stanton J Kochanek, Julie L. Eiseman, Tongying Shun, Allen Xinwei Wang, David A Close, Philip E. Empey
Publikováno v:
SLAS Discovery. 24:653-668
Systematic unbiased high-throughput screening (HTS) of drug combinations (DCs) in well-characterized tumor cell lines is a data-driven strategy to identify novel DCs with potential to be developed into effective therapies. Four DCs from a DC HTS camp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a341cbca337474824667c48ec9b8746a
https://doi.org/10.1177/2472555219844566
https://doi.org/10.1177/2472555219844566
Autor:
Mark T. Miedel, Anthony Saleh, Lawrence Vernetti, Richard DeBiasio, Alaa Alsebahi, Kristin M. Bircsak, Ryan Reddinger, Albert Gough, Tongying Shun
Publikováno v:
Toxicology. 450
We report the development, automation and validation of a 3D, microfluidic liver-on-a-chip for high throughput hepatotoxicity screening, the OrganoPlate LiverTox™. The model is comprised of aggregates of induced pluripotent stem cell (iPSC)-derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161d0fd3e7d919bc7601cb061ebc7f8d
https://pubmed.ncbi.nlm.nih.gov/33359578
https://pubmed.ncbi.nlm.nih.gov/33359578
Autor:
Diane L. Carlisle, Robert M. Friedlander, Anton Simeonov, Hongchun Li, Murat Can Cobanoglu, Fen Pei, Mark J. Henderson, Andrew M. Stern, Tongying Shun, Timothy R. Lezon, Seyed H Mousavi, D. Lansing Taylor, Steve Titus, Lee Apostle Mcdermott, Michael Fioravanti, Prema Iyer, Mark E. Schurdak, Ivet Bahar, Ajit Jadhav
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Scientific Reports
Scientific Reports
Quantitative Systems Pharmacology (QSP) is a drug discovery approach that integrates computational and experimental methods in an iterative way to gain a comprehensive, unbiased understanding of disease processes to inform effective therapeutic strat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75064ea43dd18201b922d197c80331f
http://link.springer.com/article/10.1038/s41598-017-17378-y
http://link.springer.com/article/10.1038/s41598-017-17378-y
Autor:
Kochanek, Stanton J., Close, David A., Wang, Allen Xinwei, Tongying Shun, Empey, Philip E., Eiseman, Julie L., Johnston, Paul A.
Supplemental material, DS_DISC844566 for Confirmation of Selected Synergistic Cancer Drug Combinations Identified in an HTS Campaign and Exploration of Drug Efflux Transporter Contributions to the Mode of Synergy by Stanton J. Kochanek, David A. Clos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0ba82f7c0ebd376b1e08722940bf22
Autor:
Stanton J Kochanek, David A Close, Tongying Shun, Julie L. Eiseman, Allen Xinwei Wang, Paul A. Johnston
Publikováno v:
SLAS discovery : advancing life sciences RD. 24(3)
Animal and clinical studies demonstrate that cancer drug combinations (DCs) are more effective than single agents. However, it is difficult to predict which DCs will be more efficacious than individual drugs. Systematic DC high-throughput screening (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a0bce75f70882c66b178c5ca7a1bfd
https://pubmed.ncbi.nlm.nih.gov/30500310
https://pubmed.ncbi.nlm.nih.gov/30500310
Autor:
Minh M Nguyen, Junkui Ai, Tongying Shun, Gabriela Mustata Wilson, Peter Wipf, Sunita Shinde, Paul A. Johnston, Javid A. Dar, Daniel P. Camarco, Yun Hua, Joel B. Nelson, Zhou Wang, Khalid Z. Masoodi, John S. Lazo, Yujuan Wang, Donna M. Huryn
Publikováno v:
ASSAY and Drug Development Technologies. 14:226-239
Patients with castration-resistant prostate cancer (CRPC) can be treated with abiraterone, a potent inhibitor of androgen synthesis, or enzalutamide, a second-generation androgen receptor (AR) antagonist, both targeting AR signaling. However, most pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dbc28f7ced5e72473caff12a3105d00
https://doi.org/10.1089/adt.2016.716
https://doi.org/10.1089/adt.2016.716
Zebrafish embryos are a near-ideal animal model for drug discovery because of their high genetic and physiological similarity to mammals, small size, high fecundity, and optical transparency. The latter properties make zebrafish at larval stages espe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec1d99a554d1218a95599c859ffc61c
https://europepmc.org/articles/PMC5576098/
https://europepmc.org/articles/PMC5576098/