Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Tongye Shen"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2240-2250 (2024)
The 3D conformations of chromosomes can encode biological significance, and the implications of such structures have been increasingly appreciated recently. Certain chromosome structural features, such as A/B compartmentalization, are frequently extr
Externí odkaz:
https://doaj.org/article/0c0697b30ae44fc49d46b7a871f4414d
Autor:
Michael T. Harnish, Daniel Lopez, Corbin T. Morrison, Ramesh Narayanan, Elias J. Fernandez, Tongye Shen
Publikováno v:
Biology, Vol 12, Iss 11, p 1442 (2023)
Intrinsically disordered regions (IDRs) of transcription factors play an important biological role in liquid condensate formation and gene regulation. It is thus desirable to investigate the druggability of IDRs and how small-molecule binders can alt
Externí odkaz:
https://doaj.org/article/79683acb2a80419ab965edbec959705d
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 8, p e1010392 (2022)
Inside the nucleus, chromosomes are subjected to direct physical interaction between different components, active forces, and thermal noise, leading to the formation of an ensemble of three-dimensional structures. However, it is still not well unders
Externí odkaz:
https://doaj.org/article/f7febf0778b84278bf23c6e92d5e573d
Autor:
Bill Pham, Ziju Cheng, Daniel Lopez, Richard J. Lindsay, David Foutch, Rily T. Majors, Tongye Shen
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The receptor RORγ belongs to the nuclear receptor superfamily that senses small signaling molecules and regulates at the gene transcription level. Since RORγ has a high basal activity and plays an important role in immune responses, inhibitors targ
Externí odkaz:
https://doaj.org/article/2f6a538dd86b4cf2999bfe9c1ebee9d2
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 3599-3608 (2021)
Network analysis has emerged as a powerful tool for examining structural biology systems. The spatial organization of the components of a biomolecular structure has been rendered as a graph representation and analyses have been performed to deduce th
Externí odkaz:
https://doaj.org/article/e908afa4a76f44d7b954262f8b82ff97
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-28 (2020)
Abstract Background The nonrandom radial organization of eukaryotic chromosome territories (CTs) inside the nucleus plays an important role in nuclear functional compartmentalization. Increasingly, chromosome conformation capture (Hi-C) based approac
Externí odkaz:
https://doaj.org/article/78521c13a7334b769f09b403fe8cc4ff
Publikováno v:
Molecules, Vol 20, Iss 5, Pp 7700-7718 (2015)
Carbohydrate recognition by proteins, such as lectins and other (bio)molecules, can be essential for many biological functions. Recently, interest has arisen due to potential protein and drug design and future bioengineering applications. A quantitat
Externí odkaz:
https://doaj.org/article/642b31ce8a404882907fe3637c78da16
Autor:
S Gnanakaran, Tanmoy Bhattacharya, Marcus Daniels, Brandon F Keele, Peter T Hraber, Alan S Lapedes, Tongye Shen, Brian Gaschen, Mohan Krishnamoorthy, Hui Li, Julie M Decker, Jesus F Salazar-Gonzalez, Shuyi Wang, Chunlai Jiang, Feng Gao, Ronald Swanstrom, Jeffrey A Anderson, Li-Hua Ping, Myron S Cohen, Martin Markowitz, Paul A Goepfert, Michael S Saag, Joseph J Eron, Charles B Hicks, William A Blattner, Georgia D Tomaras, Mohammed Asmal, Norman L Letvin, Peter B Gilbert, Allan C Decamp, Craig A Magaret, William R Schief, Yih-En Andrew Ban, Ming Zhang, Kelly A Soderberg, Joseph G Sodroski, Barton F Haynes, George M Shaw, Beatrice H Hahn, Bette Korber
Publikováno v:
PLoS Pathogens, Vol 7, Iss 9, p e1002209 (2011)
Here we have identified HIV-1 B clade Envelope (Env) amino acid signatures from early in infection that may be favored at transmission, as well as patterns of recurrent mutation in chronic infection that may reflect common pathways of immune evasion.
Externí odkaz:
https://doaj.org/article/22d53c62f6de46ae98a1717e386d0e84
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 3599-3608 (2021)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
Network analysis has emerged as a powerful tool for examining structural biology systems. The spatial organization of the components of a biomolecular structure has been rendered as a graph representation and analyses have bee
Network analysis has emerged as a powerful tool for examining structural biology systems. The spatial organization of the components of a biomolecular structure has been rendered as a graph representation and analyses have bee
Publikováno v:
PLoS computational biology. 18(8)
Inside the nucleus, chromosomes are subjected to direct physical interaction between different components, active forces, and thermal noise, leading to the formation of an ensemble of three-dimensional structures. However, it is still not well unders