Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Tongsen, Zheng"'
Autor:
Xianjun Li, Tianjun Chen, Xuehan Li, Hanyu Zhang, Yingjing Li, Shuyuan Zhang, Shengnan Luo, Tongsen Zheng
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-20 (2024)
Abstract Chimeric antigen receptor (CAR) T cell therapy, which targets tumors with high specificity through the recognition of particular antigens, has emerged as one of the most rapidly advancing modalities in immunotherapy, demonstrating substantia
Externí odkaz:
https://doaj.org/article/856a1647235f462793d6ed0e80614606
Autor:
Wenmeng Wang, Dangdang Li, Qingqing Xu, Jiahui Cheng, Zhiwei Yu, Guangyue Li, Shiyao Qiao, Jiasong Pan, Hao Wang, Jinming Shi, Tongsen Zheng, Guangchao Sui
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract G-quadruplexes (G4s) can recruit transcription factors to activate gene expression, but detailed mechanisms remain enigmatic. Here, we demonstrate that G4s in the CCND1 promoter propel the motility in MAZ phase-separated condensates and subs
Externí odkaz:
https://doaj.org/article/270e1586a19344b1abcaa51a6a6d0f85
Autor:
Jiaqi Shi, Caiqi Liu, Shengnan Luo, Yingying Zhang, Mingwei Li, Meng Zhou, Mingjiao Weng, Xiaobo Li, Tongsen Zheng
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102172- (2023)
Summary: Here, we present a protocol for the detection of the two STING isoforms (erSTING and pmSTING) in human peripheral blood mononuclear cells or mouse splenocytes using Western blot and PCR. We detail steps to construct plasmids encoding each is
Externí odkaz:
https://doaj.org/article/e5352800a802423e8d795cd9f2ab9fe0
Autor:
Guangyu Wang, Dandan Xu, Zicheng Zhang, Xinhui Li, Jiaqi Shi, Jie Sun, Huan-Zhong Liu, Xiaobo Li, Meng Zhou, Tongsen Zheng
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-10 (2021)
Abstract An emerging body of evidence has recently recognized the coexistence of epithelial-mesenchymal transition (EMT) and immune response. However, a systems-level view and survey of the interplay between EMT and immune escape program, and their i
Externí odkaz:
https://doaj.org/article/3264fe39908f46e184a6d431d2115a42
Autor:
Meng Zhou, Dan Shan, Chunhui Zhang, Jianhua Nie, Guangyu Wang, Yanqiao Zhang, Yang Zhou, Tongsen Zheng
Publikováno v:
BMC Medical Imaging, Vol 21, Iss 1, Pp 1-10 (2021)
Abstract Background The objective of this study was to analyze the accuracy of gadolinium–ethoxybenzyl–diethylenetriamine penta–acetic acid enhanced magnetic resonance imaging (Gd–EOB–DTPA–MRI) for predicting microvascular invasion (MVI)
Externí odkaz:
https://doaj.org/article/2b6e358ea5f8416ca03ddf903966902e
Autor:
Jian Zhou, Xinhui Li, Minghui Zhang, Ji’nan Gong, Qi Li, Baocong Shan, Tianzhen Wang, Lei Zhang, Tongsen Zheng, Xiaobo Li
Publikováno v:
Cancer Medicine, Vol 9, Iss 5, Pp 1818-1829 (2020)
Abstract Although emerging studies showed that certain rhythm genes regulate cancer progression, the expression and roles of the vast majority of rhythm genes in human cancer are largely unknown, and the hallmarks of cancer regulated by rhythm genes
Externí odkaz:
https://doaj.org/article/f1b4552d8f9d4e10a97741074c64074f
Autor:
Xiaobo Li, Yuanyuan Zhu, Xiao Zhang, Xiang An, Mingjiao Weng, Jiaqi Shi, Song Wang, Caiqi Liu, Shengnan Luo, Tongsen Zheng
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 3 (2022)
It has been revealed that 2′3′-cyclic-GMP-AMP (cGAMP), a second messenger that activates the antiviral stimulator of IFN genes (STING), elicits an antitumoral immune response. Since cGAMP cannot cross the cell membrane, it is not clear how intrac
Externí odkaz:
https://doaj.org/article/8cb7d11eb2264769a5b066b6aa81b267
Autor:
Meng Zhou, Chunhui Zhang, Jianhua Nie, Yajuan Sun, Ye Xu, Fangfang Wu, Yuhong Huang, Shun Li, Yuan Wang, Yang Zhou, Tongsen Zheng
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundPrecise evaluation of the efficacy of immunotherapy is critical in the effective management and treatment of advanced hepatocellular carcinoma (HCC). Therefore, the purpose of this study was to compare the response assessments achieved by d
Externí odkaz:
https://doaj.org/article/724dc3a989804d50aa03aaeb2e8e795c
Publikováno v:
Therapeutic Advances in Gastroenterology, Vol 14 (2021)
Helicobacter pylori (HP) is a major causative agent of chronic gastritis and peptic ulcer. HP is also engaged in the development of gastric cancer and gastric mucosa-associated lymphoid tissue lymphoma. It is an important pathogenic factor in various
Externí odkaz:
https://doaj.org/article/48c1e2708f0d485aa087cddd3ffdb9be
Publikováno v:
Molecular Cancer, Vol 18, Iss 1, Pp 1-15 (2019)
Abstract The aberrant appearance of DNA in the cytoplasm triggers the activation of cGAS-cGAMP-STING signaling and induces the production of type I interferons, which play critical roles in activating both innate and adaptive immune responses. Recent
Externí odkaz:
https://doaj.org/article/73bd097f8b674b2b81d296eeb06cdb46