Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Tongqian Chen"'
Publikováno v:
Metals, Vol 14, Iss 4, p 401 (2024)
High-strength and lightweight 7XXX Al alloys are widely applied in aerospace industries. Stress corrosion cracking (SCC) in these alloys has been extensively discussed, and electrochemical corrosion should be brought to the forefront when these mater
Externí odkaz:
https://doaj.org/article/c647f7cec83e41ba8819fd2e1f586fa7
Autor:
Antitsa Dimitrova Stoycheva, Leonid Beigelman, Tongqian Chen, Kenneth Shaw, Vivek K. Rajwanshi, Zhinan Jin, Andreas Jekle, Yujian Hu, Kusum Gupta, Caroline Williams, Amy Fung, Guangyi Wang, Vladimir Serebryany, Natalia B. Dyatkina, Xiangyang Wu, Marija Prhavc, Jerome Deval, David B. Smith, Wensheng Huang, Yuen Tam, Yongfei Huang
Publikováno v:
Journal of Medicinal Chemistry. 63:10380-10395
Chronic hepatitis C (CHC) is a major liver disease caused by the hepatitis C virus. The current standard of care for CHC can achieve cure rates above 95%; however, the drugs in current use are administered for a period of 8-16 weeks. A combination of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a823c2f5eb258939c818fe7c940eb7e5
https://doi.org/10.1021/acs.jmedchem.0c00935
https://doi.org/10.1021/acs.jmedchem.0c00935
Autor:
Guangyi, Wang, Natalia, Dyatkina, Marija, Prhavc, Caroline, Williams, Vladimir, Serebryany, Yujian, Hu, Yongfei, Huang, Xiangyang, Wu, Tongqian, Chen, Wensheng, Huang, Vivek K, Rajwanshi, Jerome, Deval, Amy, Fung, Zhinan, Jin, Antitsa, Stoycheva, Kenneth, Shaw, Kusum, Gupta, Yuen, Tam, Andreas, Jekle, David B, Smith, Leonid, Beigelman
Publikováno v:
Journal of medicinal chemistry. 63(18)
Chronic hepatitis C (CHC) is a major liver disease caused by the hepatitis C virus. The current standard of care for CHC can achieve cure rates above 95%; however, the drugs in current use are administered for a period of 8-16 weeks. A combination of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::de58cf32074b333da6c532814bbb0408
https://pubmed.ncbi.nlm.nih.gov/32816483
https://pubmed.ncbi.nlm.nih.gov/32816483
Autor:
Ruijun Sun, David B. Olsen, Peter T. Meinke, Yunfeng Bai, Zhibo Zhang, Stephane L. Bogen, Vinay Girijavallabhan, Tongqian Chen, Jie Yin, Qun Dang
Publikováno v:
Tetrahedron Letters. 55:5576-5579
To discover novel nucleosides as potential anti-HCV agents, nucleosides with a 1′,2′-β-lactam moiety were designed as a hybrid scaffold of MK-608 and GS-6620. Synthetic strategies were successfully developed to prepare two series of C-nucleoside
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::729ad0fb26be132e167b094c1e4af45d
https://doi.org/10.1016/j.tetlet.2014.08.072
https://doi.org/10.1016/j.tetlet.2014.08.072
Autor:
Qun Dang, Vinay Girijavallabhan, Peter T. Meinke, David B. Olsen, Shuangsheng He, Yang Song, Tongqian Chen, Zhibo Zhang, Xinglin He, Stephane L. Bogen, Bing-Yu Tang
Publikováno v:
Tetrahedron Letters. 55:5092-5095
To discover novel nucleosides as potential antiviral agents, 1′,2′-cyclopentyl nucleosides were designed as hybrids of sofosbuvir and GS - 6620 . An asymmetric aldol condensation reaction was used as the key transformation to prepare the versatil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f24e1d18bedfa9fc47cb36bb0fa8edc2
https://doi.org/10.1016/j.tetlet.2014.07.037
https://doi.org/10.1016/j.tetlet.2014.07.037
Autor:
Yang Song, Peter T. Meinke, Vinay Girijavallabhan, Qun Dang, Ling Wu, Bing-Yu Tang, Stephane L. Bogen, Zhibo Zhang, David B. Olsen, Tongqian Chen
Publikováno v:
Tetrahedron Letters. 55:3813-3816
To discover novel nucleosides as potential antiviral agents, 2′-spirolactam and 2′-spiropyrrolidine-containing nucleoside analogs were envisioned. Efficient synthetic routes were developed with an epoxide opening as the key step to establish the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b909d55be891d0936f95d1dd7235bdbe
https://doi.org/10.1016/j.tetlet.2014.05.051
https://doi.org/10.1016/j.tetlet.2014.05.051
Autor:
Yaohong Liu, Vinay Girijavallabhan, Tongqian Chen, Zhibo Zhang, Qun Dang, David B. Olsen, Stephane L. Bogen, Peter T. Meinke, Shuangsheng He
Publikováno v:
Tetrahedron Letters. 55:4407-4409
To discover novel nucleosides as potential antiviral agents, 4′-spirocyclic phosphono-nucleosides were designed to mimic the monophosphate of R-1479, a known nucleoside inhibitor of HCV NS5B. Bypassing the first kinase step to nucleoside monophosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d40bbbc32931f49ce9245ec5339353d
https://doi.org/10.1016/j.tetlet.2014.06.029
https://doi.org/10.1016/j.tetlet.2014.06.029
Autor:
Tongqian Chen, Tesfamichael Haile, Daniel J. Berger, Manchao Xiao, Deqing Lei, Ping Jiang, Dong Ho Pae, William R. Winchester, Peter P. Gaspar
Publikováno v:
Journal of Organometallic Chemistry. 646:68-79
The scarcity of triplet silylenes compared with triplet carbenes can be understood in terms of the sizes of the valence orbitals. The larger size of the silicon orbitals leads to a decrease in the repulsion of the nonbonding electrons in the singlet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04ab28ac3514cd34d6374bcd8c1a6c0a
https://doi.org/10.1016/s0022-328x(01)01464-4
https://doi.org/10.1016/s0022-328x(01)01464-4
Autor:
Bing-Yu Tang, Qun Dang, Stephane L. Bogen, David B. Olsen, Tongqian Chen, Vinay Girijavallabhan, Ling Wu, Peter T. Meinke, Zhibo Zhang, Yang Song
Publikováno v:
ChemInform. 45
The synthesis of nucleosides with 2-spirolactam (III) and 2-spiropyrrolidine (IV) moiety is based on the key intermediate (II) which is obtained through epoxide ring opening.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ec11292015c095df5bcf2186b1e5f27
https://doi.org/10.1002/chin.201450195
https://doi.org/10.1002/chin.201450195
Publikováno v:
Journal of the American Chemical Society. 122:3861-3866
A contrathermodynamic sequence selectivity (5‘-deoxyadenosine > 5‘-deoxyguanosine) for UV-irradiation-induced strand damage in duplex DNA containing 5-bromo-2‘-deoxyuridine was reported several years ago (Saito, I.; Sugiyama, H. J. Am. Chem. So
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1473fb5608104adea88960c66450714a
https://doi.org/10.1021/ja994357i
https://doi.org/10.1021/ja994357i